Nociception and sensory nerves as regulators of type 2 immunity and skin inflammation

Project Information

IMMCEPTION

Grant agreement ID: 802041

DOI

10.3030/802041

Project closed

EC signature date 26 November 2018

Start date 1 January 2019

End date 31 December 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 497 441,00

EU contribution

€ 1 497 441,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (14)

IgE antibodies increase honeybee venom responsiveness and detoxification efficiency of mast cells

Author(s): Philipp Starkl, Nicolas Gaudenzio, Thomas Marichal, Laurent L. Reber, Riccardo Sibilano, Martin L. Watzenboeck, Frédéric Fontaine, André C. Mueller, Mindy Tsai, Sylvia Knapp, Stephen J. Galli
Published in: Allergy, 2021, ISSN 0105-4538
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/all.14852

MRGPRX2 sensing of cationic compounds—A bridge between nociception and skin diseases?

Author(s): Auriane Corbière, Alexia Loste, Nicolas Gaudenzio
Published in: Experimental Dermatology, Issue 30/2, 2021, Page(s) 193-200, ISSN 0906-6705
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/exd.14222

3-D deconvolution of human skin immune architecture with Multiplex Annotated Tissue Imaging System (MANTIS)

Author(s): Manon Scholaert; Raissa Houmadi; Jeremy Martin; Nadine Serhan; Marie Tauber; Emilie Braun; Lilian Basso; Eric Merle; Pascal Descargues; Manuelle Viguier; Cécile Lesort; Benoît Chaput; Jean Kanitakis; Denis Jullien; Cristina Bulai Livideanu; Laurence Lamant; Emeline Pagès; Nicolas Gaudenzio
Published in: Science Advances, Issue 7, 2023, ISSN 2375-2548
Publisher: Science Publishing Group
DOI: 10.1101/2023.01.13.523748

Landscape of mast cell populations across organs in mice and humans

Author(s): Marie Tauber; Lilian Basso; Jeremy Martin; Luciana Bostan; Marlene Magalhaes Pinto; Guilhem R. Thierry; Raïssa Houmadi; Nadine Serhan; Alexia Loste; Camille Blériot; Jasper B.J. Kamphuis; Mirjana Grujic; Lena Kjellén; Gunnar Pejler; Carle Paul; Xinzhong Dong; Stephen J. Galli; Laurent L. Reber; Florent Ginhoux; Marc Bajenoff; Rebecca Gentek; Nicolas Gaudenzio
Published in: Journal of Experimental Medicine, Issue 1, 2023, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20230570

Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome

Author(s): Julien Stackowicz, Nicolas Gaudenzio, Nadine Serhan, Eva Conde 1, Ophélie Godon 1, Thomas Marichal 4, Philipp Starkl 5 6, Bianca Balbino 1 2, Axel Roers 7, Pierre Bruhns 1, Friederike Jönsson 1, Philippe Moguelet 8, Sophie Georgin-Lavialle 9, Lori Broderick 10, Hal M Hoffman 10, Stephen J Galli 11 12 13, Laurent L Reber 1 2
Published in: Journal of Experimental Medicine, 2021, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20201466

Mas-related G protein-coupled receptors (Mrgprs) – Key regulators of neuroimmune interactions

Author(s): Nadine Serhan, Nicolas Cenac, Lilian Basso, Nicolas Gaudenzio
Published in: Neuroscience Letters, Issue 749, 2021, Page(s) 135724, ISSN 0304-3940
Publisher: Elsevier BV
DOI: 10.1016/j.neulet.2021.135724

Comment on “Tumor-initiating cells establish an IL-33–TGF-β niche signaling loop to promote cancer progression”

Author(s): Jasper B. J. Kamphuis, William P. M. Worrall, Julien Stackowicz, Aurélie Mougel, Emilie Mauré, Eva Conde, Pierre Bruhns, Laurent Guilleminault, Nicolas Gaudenzio, Jinmiao Chen, Rebecca Gentek, Laurent L. Reber
Published in: Science, Issue 372/6538, 2021, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abf2022

Bidirectional sensory neuron–immune interactions: a new vision in the understanding of allergic inflammation

Author(s): Marie Tauber, Fang Wang, Brian Kim, Nicolas Gaudenzio
Published in: Current Opinion in Immunology, Issue 72, 2021, Page(s) 79-86, ISSN 0952-7915
Publisher: Elsevier BV
DOI: 10.1016/j.coi.2021.03.012

IgE Effector Mechanisms, in Concert with Mast Cells, Contribute to Acquired Host Defense against Staphylococcus aureus

Author(s): Philipp Starkl, Martin L. Watzenboeck, Lauren M. Popov, Sophie Zahalka, Anastasiya Hladik, Karin Lakovits, Mariem Radhouani, Arvand Haschemi, Thomas Marichal, Laurent L. Reber, Nicolas Gaudenzio, Riccardo Sibilano, Lukas Stulik, Frédéric Fontaine, André C. Mueller, Manuel R. Amieva, Stephen J. Galli, Sylvia Knapp
Published in: Immunity, Issue 53/4, 2020, Page(s) 793-804.e9, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2020.08.002

House dust mites activate nociceptor–mast cell clusters to drive type 2 skin inflammation

Author(s): Nadine Serhan, Lilian Basso, Riccardo Sibilano, Camille Petitfils, James Meixiong, Chrystelle Bonnart, Laurent L. Reber, Thomas Marichal, Philipp Starkl, Nicolas Cenac, Xinzhong Dong, Mindy Tsai, Stephen J. Galli, Nicolas Gaudenzio
Published in: Nature Immunology, Issue 20/11, 2019, Page(s) 1435-1443, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-019-0493-z

Rapid identification of human mast cell degranulation regulators using functional genomics coupled to high-resolution confocal microscopy

Author(s): Jelle Folkerts, Nicolas Gaudenzio, Marcus Maurer, Rudi W. Hendriks, Ralph Stadhouders, See-Ying Tam, Stephen J. Galli
Published in: Nature Protocols, Issue 15/3, 2020, Page(s) 1285-1310, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-019-0288-6

Peripheral neurons: Master regulators of skin and mucosal immune response

Author(s): Lilian Basso, Nadine Serhan, Marie Tauber, Nicolas Gaudenzio
Published in: European Journal of Immunology, Issue 49/11, 2019, Page(s) 1984-1997, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201848027

A Connective Tissue Mast-Cell-Specific Receptor Detects Bacterial Quorum-Sensing Molecules and Mediates Antibacterial Immunity

Author(s): Priyanka Pundir, Rui Liu, Chirag Vasavda, Nadine Serhan, Nathachit Limjunyawong, Rebecca Yee, Yingzhuan Zhan, Xintong Dong, Xueqing Wu, Ying Zhang, Solomon H. Snyder, Nicolas Gaudenzio, Jorge E. Vidal, Xinzhong Dong
Published in: Cell Host & Microbe, Issue 26/1, 2019, Page(s) 114-122.e8, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2019.06.003

Mast Cells in Inflammation and Disease: Recent Progress and Ongoing Concerns

Author(s): Stephen J. Galli, Nicolas Gaudenzio, Mindy Tsai
Published in: Annual Review of Immunology, Issue 38/1, 2020, Page(s) 49-77, ISSN 0732-0582
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-immunol-071719-094903