Unravelling the Interplay between Metabolism, Gut Microbiome and Adaptive Immunity in Amyotrophic Lateral Sclerosis

Project Information

MegaALS

Grant agreement ID: 802091

DOI

10.3030/802091

Project closed

EC signature date 30 October 2018

Start date 1 November 2018

End date 31 October 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 196,00

EU contribution

€ 1 499 196,00

Coordinated by

KAROLINSKA INSTITUTET
Sweden

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

Immune cells and the trajectories of depression, anxiety, and cognitive function among people with amyotrophic lateral sclerosis

Author(s): Yihan Hu, Elie Deeba, Ulf Kläppe, Linn Öijerstedt, John Andersson, Nicolas Ruffin, Fredrik Piehl, Caroline Ingre, Fang Fang, Christina Seitz
Published in: Brain, Behavior, & Immunity - Health, Issue 42, 2025, Page(s) 100907, ISSN 2666-3546
Publisher: Academic Press
DOI: 10.1016/j.bbih.2024.100907

Lifestyle and medical conditions in relation to ALS risk and progression—an introduction to the Swedish ALSrisc Study

Author(s): Charilaos Chourpiliadis, Christina Seitz, Anikó Lovik, Emily E. Joyce, Lu Pan, Yihan Hu, Ulf Kläppe, Kristin Samuelsson, Rayomand Press, Caroline Ingre, Fang Fang
Published in: Journal of Neurology, Issue 271, 2024, Page(s) 5447-5459, ISSN 0340-5354
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-024-12496-w

Association Between Early‐Life and Premorbid Measurements of Body Composition and Risk of Motor Neuron Disease: A Prospective Cohort Study in the <scp>UK</scp> Biobank

Author(s): Emily E. Joyce, Shishi Xu, Caroline Ingre, Rosa Luisa Potenza, Christina Seitz, Huazhen Yang, Yu Zeng, Huan Song, Fang Fang
Published in: Annals of Neurology, Issue 97, 2025, Page(s) 259-269, ISSN 0364-5134
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ana.27109

Cardiac troponin T is elevated and increases longitudinally in ALS patients

Author(s): Ulf Kläppe, Sanharib Chamoun, Qing Shen, Anja Finn, Björn Evertsson, Henrik Zetterberg, Kaj Blennow, Rayomand Press, Kristin Samuelsson, Anna Månberg, Fang Fang, Caroline Ingre
Published in: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Issue 23, 2022, Page(s) 58-65, ISSN 2167-8421
Publisher: Informa Healthcare
DOI: 10.1080/21678421.2021.1939384

Exploring clinical chemistry markers in amyotrophic lateral sclerosis: insights into survival and disease trajectories

Author(s): Ioannis Psychogios, Yihan Hu, Christina Seitz, Emily E. Joyce, Anikó Lovik, Caroline Ingre, Fang Fang
Published in: Journal of Neurology, Issue 272, 2025, ISSN 0340-5354
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-024-12774-7

Medication use and risk of amyotrophic lateral sclerosis—a systematic review

Author(s): Can Cui, Jiangwei Sun, Kyla A. McKay, Caroline Ingre, Fang Fang
Published in: BMC Medicine, Issue 20, 2023, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-022-02442-w

Association between cardiometabolic diseases and the risk and progression of motor neuron diseases in Sweden: a population-based case–control study

Author(s): Charilaos Chourpiliadis, Anikó Lovik, Christina Seitz, Yihan Hu, Jing Wu, Petter Ljungman, Rayomand Press, Kristin Samuelsson, Caroline Ingre, Fang Fang
Published in: The Lancet Regional Health - Europe, Issue 49, 2025, Page(s) 101173, ISSN 2666-7762
Publisher: The Lancet
DOI: 10.1016/j.lanepe.2024.101173

Peripheral immune biomarkers and neurodegenerative diseases: A prospective cohort study with 20 years of follow‐up

Author(s): Solmaz Yazdani, Daniela Mariosa, Niklas Hammar, John Andersson, Caroline Ingre, Göran Walldius, Fang Fang
Published in: Annals of Neurology, Issue 86/6, 2019, Page(s) 913-926, ISSN 0364-5134
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ana.25614

Correlation between leukocyte phenotypes and prognosis of amyotrophic lateral sclerosis

Author(s): Can Cui, Caroline Ingre, Li Yin, Xia Li, John Andersson, Christina Seitz, Nicolas Ruffin, Yudi Pawitan, Fredrik Piehl, Fang Fang
Published in: eLife, Issue 11, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.74065

Lipids, apolipoproteins, and prognosis of amyotrophic lateral sclerosis

Author(s): Caroline Ingre, Lin Chen, Yiqiang Zhan, Jet Termorshuizen, Li Yin, Fang Fang
Published in: Neurology, Issue 94/17, 2020, Page(s) e1835-e1844, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000009322

T cell subset composition differs between blood and cerebrospinal fluid in amyotrophic lateral sclerosis

Author(s): Solmaz Yazdani, Anikó Lovik, Christina Seitz, Caroline Ingre, Fang, Fang, John Andersson
Published in: Clinical Immunology, 2024, ISSN 1521-6616
Publisher: Academic Press

T cell responses at diagnosis of amyotrophic lateral sclerosis predict disease progression

Author(s): Solmaz Yazdani, Christina Seitz, Can Cui, Anikó Lovik, Lu Pan, Fredrik Piehl, Yudi Pawitan, Ulf Kläppe, Rayomand Press, Kristin Samuelsson, Li Yin, Trung Nghia Vu, Anne-Laure Joly, Lisa S. Westerberg, Björn Evertsson, Caroline Ingre, John Andersson, Fang Fang
Published in: Nature Communications, Issue 13, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34526-9

Non-peer reviewed articles (1)

Gut microbiome and amyotrophic lateral sclerosis ‐ a systematic review of current evidence

Author(s): Jiangwei Sun, Tingting Huang, Justine W. Debelius, Fang Fang
Published in: Journal of Internal Medicine, 2021, ISSN 0954-6820
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/joim.13336

Thesis and dissertations (1)

Examining the correlation between regulatory T-cell and the progression of patients diagnosed with amyotrophic lateral sclerosis

Author(s): Tomas Wikström, Christina Seitz
Published in: 2020
Publisher: N/A