Molecular mechanisms underlying selective neuronal death in motor neuron diseases

Project Information

Neurovulnerability

Grant agreement ID: 802182

DOI

10.3030/802182

Project closed

EC signature date 27 November 2018

Start date 1 August 2019

End date 31 July 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 472 667,34

EU contribution

€ 1 472 667,34

Coordinated by

DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV
Germany

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Other (2)

Altered lysosomal biology impairs motor neuron survival via TFEB dysregulation in spinal muscular atrophy

Author(s): Ines Rosignol, Zeynep Dokuzluoglu, Antonio Caldarelli, Ana-Maria Oprişoreanu, Sofiia Ushakova, Tohid Siddiqui, Rahul Grover, Hannes Guerlich, Björn Falkenburger, Stefan Diez, Tobias Grass, Catherina G. Becker, Natalia Rodriguez-Muela
Published in: bioRxiv, Issue (under review in a journal), 2025, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.07.07.663525

Synchronous 3D patterning of diverse CNS progenitors generates motor neurons of broad axial identity

Author(s): Felix Buchner, Zeynep Dokuzluoglu, Joshua Thomas, Antonio Caldarelli, Shrutika Kavali, Fabian Rost, Tobias Grass, Natalia Rodríguez-Muela
Published in: bioRxiv, Issue (under review in a journal), 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.12.13.628384

Thesis and dissertations (2)

SMN Protein Heterogeneity Drives Intrinsic Motor Neuron Vulnerability through Survival and Activity Related Pathways

Author(s): Joshua Thomas
Published in: 2024
Publisher: TUD (URN Qucosa)

Understanding how SMN protein regulates the autophagy-lysosome pathway in spinal muscular atrophy

Author(s): Ines Rosignol
Published in: 2024
Publisher: TUD (URN Qucosa)