Recurrent disease in the liver transplant: window to identify and stop gut signals driving autoimmunity

Project Information

StopAutoimmunity

Grant agreement ID: 802544

DOI 10.3030/802544

Project closed

EC signature date 29 January 2019

Start date 1 April 2019

End date 31 March 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 500 000,00

EU contribution € 1 500 000,00

Coordinated by

UNIVERSITETET I OSLO
Norway

Publications

Peer reviewed articles (8)

Suppression of bile acid synthesis as a tipping point in the disease course of primary sclerosing cholangitis

Author(s): Peder R. Braadland; Kai Marcus Schneider; Annika Bergquist; Antonio Molinaro; Anita Lövgren-Sandblom A; Marcus Henricsson; Tom H. Karlsen; Mette Vesterhus; Christian Trautwein; Johannes R Hov; Hanns-Ulrich Marschall
Published in: JHEP Reports, Issue 2022 Aug 18;4(11), 2022, ISSN 2589-5559
Publisher: Elsevier
DOI: 10.1016/j.jhepr.2022.100561

A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

Author(s): Mikal Jacob Hole; Kristin Kaasen Jørgensen; Kristian Holm; Peder R. Braadland; Malin Holm Meyer‐Myklestad; Asle Wilhelm Medhus; Dag Henrik Reikvam; Alexandra Götz; Krzysztof Grzyb; Kirsten Muri Boberg; Tom Hemming Karlsen; Martin Kummen; Johannes R. Hov
Published in: Hepatology, Issue 3, 2023, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.32773

Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis

Author(s): Kummen M, Thingholm LB, Rühlemann MC, Holm K, Hansen SH, Moitinho-Silva L, Liwinski T, Zenouzi R, Storm-Larsen C, Midttun Ø, McCann A, Ueland PM, Høivik ML, Vesterhus M, Trøseid M, Laudes M, Lieb W, Karlsen TH, Bang C, Schramm C, Franke A, Hov JR.
Published in: Gastroenterology, Issue 160, 2021, Page(s) 1784-1798, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2020.12.058

Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4-Nitrophenyl-2H-azirine

Author(s): Weifeng Lin, Lars Gerullat, Peder R Braadland, Anaïs Fournier, Johannes R Hov, Daniel Globisch
Published in: Angew Chem Int Ed Engl, Issue 2024 Jan 18, 2024, Page(s) e202318579, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202318579

Clinical and biochemical impact of vitamin B6 deficiency in primary sclerosing cholangitis before and after liver transplantation

Author(s): Peder Rustøen Braadland; Annika Bergquist; Martin Kummen; Lars Bossen; Lise Katrine Engesæter; Henrik Mikael Reims; Ida Björk; Krzysztof Grzyb; Andreas Abildgaard; Milada Cvancarova Småstuen; Trine Folseraas; Marius Trøseid; Arve Ulvik; Per Magne Ueland; Espen Melum; Pål-Dag Line; Marte Lie Høivik; Henning Grønbæk; Tom Hemming Karlsen; Mette Vesterhus; Johannes Roksund Hov
Published in: Journal of Hepatology, Issue 79(4), 2023, Page(s) 955-966, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2023.05.038

Protective and aggressive bacterial subsets and metabolites modify hepatobiliary inflammation and fibrosis in a murine model of PSC.

Author(s): Muyiwa Awoniyi; Jeremy Wang; Billy Ngo; Vik Meadows; Jason Tam; Amba Viswanathan; Yunjia Lai; Stephanie Montgomery; Morgan Farmer; Martin Kummen; Louise Thingholm; Christoph Schramm; Corinna Bang; Andre Franke; Kun Lu; Huiping Zhou; Jasmohan S Bajaj; Phillip B Hylemon; Jenny Ting; Yury V Popov; Johannes Roksund Hov; Heather L Francis; Ryan Balfour Sartor
Published in: Gut, Issue 2, 2023, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2021-326500

Colitis ameliorates cholestatic liver disease via suppression of bile acid synthesis

Author(s): Wenfang Gui, Mikal Jacob Hole, Antonio Molinaro, Karolina Edlund, Kristin K. Jørgensen, Huan Su, Brigitte Begher-Tibbe, Nikolaus Gaßler, Carolin V. Schneider, Uthayakumar Muthukumarasamy, Antje Mohs, Lijun Liao, Julius Jaeger, Christian J. Mertens, Ina Bergheim, Till Strowig, Jan G. Hengstler, Johannes R. Hov, Hanns-Ulrich Marschall, Christian Trautwein & Kai Markus Schneider
Published in: Nature Communications, Issue 3304 (2023), 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-38840-8

Microbial-derived imidazole propionate links the heart failure-associated microbiome alterations to disease severity

Author(s): Sajan C Raju, Antonio Molinaro, Ayodeji Awoyemi, Silje F Jørgensen, Peder R Braadland, Andraz Nendl, Ingebjørg Seljeflot, Per M Ueland, Adrian McCann, Pål Aukrust, Beate Vestad, Cristiane Mayerhofer, Kaspar Broch, Lars Gullestad, Knut T Lappegård, Bente Halvorsen, Karsten Kristiansen, Johannes R Hov, Marius Trøseid
Published in: Genome Medicine, Issue 16, 2024, Page(s) Article number: 27, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/s13073-024-01296-6