Project description
Inter-species association mapping in genomics studies
The classical genetics approach does not allow the study of between-species variation as crosses between distinct species do not occur, and their genomes are usually highly rearranged. The goal of the EU-funded INTERACT project is to develop genomics-based methods for inter-species (phylogenetic) association mapping to discover signals in highly rearranged genomes of different species. The approach will be validated via its application to the variations in secondary metabolites within the Brassicaceae plant family. Secondary metabolites are highly variable and have broad application in cancer prevention, pest control and food design. The work and results of this project will significantly advance genetics research.
Objective
During the past years, great progress has been made in connecting phenotypes to genotypes based on within-species variation. However, the more dramatic variation that can be found between species has not been explored for phenotype/genotype associations so-far. Using classical genetics to mine between-species variation is mostly impossible, because crosses between distinct species hardly work and their genomes are usually highly rearranged.
The goal of this project is to develop unprecedented genomics-based methods for inter-species (phylogenetic) association mapping, which can find signals even in highly re-arranged genomes of different species. To ensure that these methods are also useful in practice, we will apply them to the variation in secondary metabolites within the Brassicaceae plant family. Secondary metabolites are highly variable, genetically controlled, easy to measure and have broad application in cancer prevention, pest control and food design. Given the great potential of phylogenetic association mapping in general and secondary metabolites in particular, our work promises to be ground-breaking and have profound impact on many different fields of genetic research.
Specifically, our work plan includes the following points:
I) We will develop strategies for phylogenetic association mapping and implement them in publicly-available software.
II) We will establish a panel of inbred lines from ~200 Brassicaceae species and generate whole-genome assemblies for each of them.
III) We will exemplify the usefulness of phylogenetic association mapping by correlating the diversity of secondary metabolites to the differences in the respective genomes and validate the results by transforming or mutating candidate genes in appropriate species.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-STG - Starting Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2018-STG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.