Periodic Reporting for period 3 - DirectThalamus (How the human thalamus guides navigation and memory: a common coding framework built on direct thalamic recordings)
Período documentado: 2022-07-01 hasta 2023-12-31
Our project examines how a specific area deep within the brain, the thalamus, contributes to memory and navigation processes in humans. The thalamus has long been thought of as a simple relay station without much impact on cognitive processes beyond transmitting signals to neocortical areas of the brain. Recent findings challenge this view and suggest that the thalamus is crucially involved in higher cognitive functions. Obtaining neural signals from the thalamus in humans with high spatial and temporal accuracy is challenging, due to its location and structure. We overcome these challenges by recording neural activity directly from the thalamus in a rare population of epilepsy patients. To treat their epilepsy, electrodes are implanted directly into the thalamus (deep brain stimulation therapy). With the electrophysiological data obtained from these electrodes, we are aiming to answer the following research questions: How does the human thalamus code and communicate information? And how does this contribute to spatial navigation and the formation and consolidation of memories?
Answering these questions is important because it will push the boundaries of the state of the art in cognitive neuroscience towards a comprehensive understanding of human cognition and will inspire new lines of research in fundamental and clinical neuroscience.
Answering these questions is important because it will push the boundaries of the state of the art in cognitive neuroscience towards a comprehensive understanding of human cognition and will inspire new lines of research in fundamental and clinical neuroscience.
We have developed and set up our experimental paradigm and successfully conducted intracranial recordings in patients. While data collection is ongoing, we implemented analyses pipelines to investigate the multimodal data (intracranial & scalp EEG, eye and motion tracking, etc). We published several papers that provide important insight into the neural underpinnings of thalamic and thalamocortical processing.
Our results challenge the traditional view of how cardinal brain oscillations are coordinated during sleep, highlighting the importance of thalamic contributions. This is important, since sleep oscillations are thought to be essential for the offline strengthening of memories. Our results also suggest that it is interactions between the neocortex and the thalamus, rather than neocortical activity alone, that is important for human cognition. Together, our findings broadly challenge current views on the neural basis of human cognition that are centered on neocortical processes without accounting for thalamic contributions and ultimately ask for a more comprehensive, thalamocortical model of cognition. Over the remaining funding period, we aim to investigate a potential causal contribution of the human thalamus to memory and navigation processes, on the basis of intracranial recordings and direct brain stimulation.