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Digital Single Cell Immunology: Decoding Cellular Interactions for Improved Immunotherapy

Project description

Understanding plasmacytoid dendritic cell heterogeneity

It has been proved that vaccination with small numbers of human plasmacytoid dendritic cells (pDCs) can induce anti-tumour immunity in metastatic cancer patients. The pDCs act to regulate the tight balance between tolerance and immunity. However, this process is not well understood. The EU-funded ImmunoCode project will explore whether pDCs possess all functions or comprise population-distinct functional subsets each with their specialised role. Moreover, it will induce cytotoxic T cells for augmented cancer immunity and develop a novel and ambitious single-cell technology platform. The platform can be exploited for any cell type that shows heterogeneous function. The findings will help with the design of differently composed cellular vaccines to fight cancer and infectious and autoimmune diseases.

Host institution

TECHNISCHE UNIVERSITEIT EINDHOVEN
Net EU contribution
€ 1 812 143,00
Address
Groene Loper 3
5612 AE Eindhoven
Netherlands

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Region
Noord-Brabant Zuidoost-Noord-Brabant
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Beneficiaries (1)

TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands
Net EU contribution
€ 1 812 143,00
Address
Groene Loper 3
5612 AE Eindhoven

See on map

Region
Noord-Brabant Zuidoost-Noord-Brabant
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00