Digital Single Cell Immunology: Decoding Cellular Interactions for Improved Immunotherapy

Project Information

ImmunoCode

Grant agreement ID: 802791

DOI

10.3030/802791

Project terminated on 1 May 2024

EC signature date 23 October 2018

Start date 1 November 2018

End date 30 June 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 812 143,00

EU contribution

€ 1 812 143,00

Coordinated by

TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (11)

Single‐Cell Profiling Reveals Functional Heterogeneity and Serial Killing in Human Peripheral and Ex Vivo‐Generated CD34+ Progenitor‐Derived Natural Killer Cells

Author(s): Nikita Subedi, Liesbeth Petronella Verhagen, Paul de Jonge, Laura C. Van Eyndhoven, Mark C. van Turnhout, Vera Koomen, Jean Baudry, Klaus Eyer, Harry Dolstra, Jurjen Tel
Published in: Advanced Biology, Issue 7, 2023, ISSN 2701-0198
Publisher: Wiley
DOI: 10.1002/adbi.202200207

Single-cell analysis reveals TLR-induced macrophage heterogeneity and quorum sensing dictate population wide anti-inflammatory feedback in response to LPS

Author(s): Bart M. Tiemeijer, Sebastiaan Heester, Ashley Y. W. Sturtewagen, Anthal I. P. M. Smits, Jurjen Tel
Published in: Frontiers in Immunology, Issue 14, 2023, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2023.1135223

A Microfluidic Approach for Probing Heterogeneity in Cytotoxic T-Cells by Cell Pairing in Hydrogel Droplets

Author(s): Bart M. Tiemeijer, Lucie Descamps, Jesse Hulleman, Jelle J. F. Sleeboom, Jurjen Tel
Published in: Micromachines, Issue 13, 2024, Page(s) 1910, ISSN 2072-666X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi13111910

Hydrogels for Single-Cell Microgel Production: Recent Advances and Applications

Author(s): B. M. Tiemeijer, J. Tel
Published in: Frontiers in Bioengineering and Biotechnology, Issue 10, 2022, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2022.891461

Cartilage-derived cells display heterogeneous pericellular matrix synthesis in agarose microgels

Author(s): Marloes van Mourik, Bart M. Tiemeijer, Maarten van Zon, Florencia Abinzano, Jurjen Tel, Jasper Foolen, Keita Ito
Published in: Matrix Biology Plus, Issue 23, 2024, Page(s) 100157, ISSN 2590-0285
Publisher: Matrix Biology Plus
DOI: 10.1016/j.mbplus.2024.100157

Microfluidic chip for precise trapping of single cells and temporal analysis of signaling dynamics

Author(s): Nidhi Sinha, Haowen Yang, David Janse, Luc Hendriks, Ulfert Rand, Hansjörg Hauser, Mario Köster, Frans N. van de Vosse, Tom F. A. de Greef, Jurjen Tel
Published in: Communications Engineering, Issue 1, 2022, ISSN 2731-3395
Publisher: Nature
DOI: 10.1038/s44172-022-00019-2

Transiently heritable fates and quorum sensing drive early IFN-I response dynamics

Author(s): Laura C. Van Eyndhoven, Vincent P.G. Verberne, Carlijn V.C. Bouten, Abhyudai Singh, Jurjen Tel
Published in: eLife, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.1101/2022.09.11.507479

An automated real-time microfluidic platform to probe single NK cell heterogeneity and cytotoxicity on-chip

Author(s): Nikita Subedi, Laura C. Van Eyndhoven, Ayla M. Hokke, Lars Houben, Mark C. Van Turnhout, Carlijn V. C. Bouten, Klaus Eyer, Jurjen Tel
Published in: Scientific Reports, Issue 11, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-96609-9

Phenotypical Diversification of Early IFNα-Producing Human Plasmacytoid Dendritic Cells Using Droplet-Based Microfluidics

Author(s): Laura C. Van Eyndhoven, Eleni Chouri, Nikita Subedi, Jurjen Tel
Published in: Frontiers in Immunology, Issue 12, 2021, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2021.672729

Engineering global and local signal generators for probing temporal and spatial cellular signaling dynamics

Author(s): Haowen Yang, Jurjen Tel
Published in: Frontiers in Bioengineering and Biotechnology, Issue 11, 2023, Page(s) 2296-4185, ISSN 2296-4185
Publisher: Frontiers in Bioengineering and Biotechnology
DOI: 10.3389/fbioe.2023.1239026

Probing Single-Cell Macrophage Polarization and Heterogeneity Using Thermo-Reversible Hydrogels in Droplet-Based Microfluidics

Author(s): B. M. Tiemeijer, M. W. D. Sweep, J. J. F. Sleeboom, K. J. Steps, J. F. van Sprang, P. De Almeida, R. Hammink, P. H. J. Kouwer, A. I. P. M. Smits, J. Tel
Published in: Frontiers in Bioengineering and Biotechnology, Issue 9, 2021, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2021.715408

Non-peer reviewed articles (1)

Unraveling IFN-I response dynamics and TNF crosstalk in the pathophysiology of systemic lupus erythematosus

Author(s): Laura C. Van Eyndhoven, Eleni Chouri, Catarina I. Matos, Aridaman Pandit, Timothy R. D. J. Radstake, Jasper C. A. Broen, Abhyudai Singh, Jurjen Tel
Published in: Frontiers in Immunology, Issue 15, 2024, Page(s) 1664-3224, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2024.1322814