Objective This ERC Starting Grant 2018 aims at the fundamental understanding of ultrafast biomolecular vibrational dynamics in the mid-IR/THz region and respective impact of nonadiabatic effects in dipolar liquids, within nano-confined environments and in the vicinity of biological interfaces. The understanding of these processes via underlying interactions is of fundamental importance with applications covering microscopic descriptions of elementary proton transfer reactions, mechanisms of energy dissipation upon vibrational excitation and solvation dynamics in biological relevant crowded environments. In particular knowledge on anisotropy of ultrafast vibrational energy relaxation together with information about distinguished intra- or inter-molecular acceptor modes, is scarce. As such the ERC Starting Grant 2018 transfers the paradigm of nonadiabatic relaxation, that has proven tremendous predictive power for descriptions of ultrafast electronic relaxation, to the low energy mid-IR/THz domain of biomolecular vibrational (energy relaxation) dynamics. As such the approach provides a description of microscopic phenomena like structural fluctuations, vibrational lifetimes and dissipation of excess energy. The proposed nonadiabatic approach to vibrational dynamics fully accounts for the strong impact of the fluctuating environment and will facilitate a concise theoretical descriptions of proton solvation structure, dynamics and transport within the confinement imposed by proton transport channel proteins. The investigation of proton mobility within reverse micelles will further facilitate the understating of proton structural diffusion within nanoscopic volumes. Such interfacial processes in the vicinity of biological membranes and proton translocation within transmembrane proteins are highly relevant as microscopic foundation of cell respiration driven by the gradient of proton concentration across membranes. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteins Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Topic(s) ERC-2018-STG - ERC Starting Grant Call for proposal ERC-2018-STG See other projects for this call Funding Scheme ERC-STG - Starting Grant Coordinator LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Net EU contribution € 587 773,26 Address Geschwister scholl platz 1 80539 Muenchen Germany See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Beneficiaries (2) Sort alphabetically Sort by Net EU contribution Expand all Collapse all LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Germany Net EU contribution € 587 773,26 Address Geschwister scholl platz 1 80539 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 FORSCHUNGSVERBUND BERLIN EV Germany Net EU contribution € 899 031,74 Address Rudower chaussee 17 12489 Berlin See on map Region Berlin Berlin Berlin Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
