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Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines

Project description

Simulations may help us understand what guides protein assembly – so we can too

Amazing things generally do not happen without an input of energy, a jarring from the status quo. As much as this holds true for people who are complacent or computers that are turned off, it is also the case for protein assembly. Proteins driven by external inputs such as chemical gradients or mechanical forces can change their structures in ways that enable them to do work. Understanding the related mechanisms would enable scientists to control the inputs and thus the outputs, applying that knowledge to therapeutics in humans or using it to create tailor-made biomimetic molecular machines. Computational models developed by the EU-funded NEPA project promise to simulate the emergence of functional behaviours in protein assemblies, opening the door to these applications.

Call for proposal

ERC-2018-STG
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Host institution

UNIVERSITY COLLEGE LONDON
Address
Gower Street
WC1E 6BT London
United Kingdom

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Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 424 574

Beneficiaries (1)

UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 1 424 574
Address
Gower Street
WC1E 6BT London

See on map

Activity type
Higher or Secondary Education Establishments