Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines

Project Information

NEPA

Grant agreement ID: 802960

DOI

10.3030/802960

Project closed

EC signature date 5 November 2018

Start date 1 October 2019

End date 30 September 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 424 574,00

EU contribution

€ 1 424 574,00

Coordinated by

INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
Austria

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (24)

PLCγ1 promotes phase separation of T cell signaling components

Author(s): Longhui Zeng, Ivan Palaia, Anđela Šarić, Xiaolei Su
Published in: Journal of Cell Biology, Issue 220/6, 2021, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202009154

Controlling cluster size in 2D phase-separating binary mixtures with specific interactions

Author(s): Palaia I, Šarić A.
Published in: The Journal of Chemical Physics. 156(19), 194902, 2022, ISSN 1089-7690
Publisher: American Institute of Physics
DOI: 10.1063/5.0087769

Mechanochemical rules for shape-shifting filaments that remodel membranes

Author(s): Meadowcroft B, Palaia I, Pfitzner AK, Roux A, Baum B, Šarić A
Published in: Physical Review Letters, Issue vol. 129, no. 26, 2022, ISSN 0031-9007
Publisher: American Physical Society
DOI: 10.1103/physrevlett.129.268101

The proteasome controls ESCRT-III–mediated cell division in an archaeon

Author(s): Gabriel Tarrason Risa, Fredrik Hurtig, Sian Bray, Anne E. Hafner, Lena Harker-Kirschneck, Peter Faull, Colin Davis, Dimitra Papatziamou, Delyan R. Mutavchiev, Catherine Fan, Leticia Meneguello, Andre Arashiro Pulschen, Gautam Dey, Siân Culley, Mairi Kilkenny, Diorge P. Souza, Luca Pellegrini, Robertus A. M. de Bruin, Ricardo Henriques, Ambrosius P. Snijders, Anđela Šarić, Ann-Christin Lindås,
Published in: Science, Issue 369/6504, 2020, Page(s) eaaz2532, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaz2532

An ESCRT-III Polymerization Sequence Drives Membrane Deformation and Fission

Author(s): Anna-Katharina Pfitzner, Vincent Mercier, Xiuyun Jiang, Joachim Moser von Filseck, Buzz Baum, Anđela Šarić, Aurélien Roux
Published in: Cell, Issue 182/5, 2020, Page(s) 1140-1155.e18, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.07.021

In Operando Imaging Electrostatic-Driven Disassembly and Reassembly of Collagen Nanostructures

Author(s): Clara Garcia-Sacristan, Victor G. Gisbert, Kevin Klein, Anđela Šarić, Ricardo Garcia
Published in: ACS Nano, Issue 18, 2024, Page(s) 18485-18492, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.4c03839

A liquid-like coat mediates chromosome clustering during mitotic exit

Author(s): Alberto Hernandez-Armendariz, Valerio Sorichetti, Yuki Hayashi, Zuzana Koskova, Andreas Brunner, Jan Ellenberg, Anđela Šarić, Sara Cuylen-Haering
Published in: Molecular Cell, Issue 84, 2024, Page(s) 3254-3270.e9, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2024.07.022

Exploring the Design Rules for Efficient Membrane-Reshaping Nanostructures

Author(s): Joel C. Forster, Johannes Krausser, Manish R. Vuyyuru, Buzz Baum, Anđela Šarić
Published in: Physical Review Letters, Issue 125/22, 2020, ISSN 0031-9007
Publisher: American Physical Society
DOI: 10.1103/physrevlett.125.228101

Influence of membrane-cortex linkers on the extrusion of membrane tubes

Author(s): Alexandru Paraschiv, Thibaut J. Lagny, Christian Vanhille Campos, Evelyne Coudrier, Patricia Bassereau, Anđela Šarić
Published in: Biophysical Journal, Issue 120/4, 2021, Page(s) 598-606, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2020.12.028

Unconventional colloidal aggregation in chiral bacterial baths

Author(s): Daniel Grober, Ivan Palaia, Mehmet Can Uçar, Edouard Hannezo, Anđela Šarić, Jérémie Palacci
Published in: Nature Physics, Issue 19, 2023, Page(s) 1680-1688, ISSN 1745-2473
Publisher: Nature Publishing Group
DOI: 10.1038/s41567-023-02136-x

Physical mechanisms of ESCRT-III-driven cell division

Author(s): Harker-Kirschneck L, Hafner AE, Yao T, Pulschen A, Vanhille-Campos C, Jiang X, Puschen A, Hurtig F, Hryniuk D, Culley S, Henriques R, Baum B, Šarić A.
Published in: Proceedings of the National Academy of Sciences, Issue Vol. 119, 2022, ISSN 1091-6490
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2107763119

Stress granules plug and stabilize damaged endolysosomal membranes

Author(s): Claudio Bussi, Agustín Mangiarotti, Christian Vanhille-Campos, Beren Aylan, Enrica Pellegrino, Natalia Athanasiadi, Antony Fearns, Angela Rodgers, Titus M. Franzmann, Anđela Šarić, Rumiana Dimova, Maximiliano G. Gutierrez
Published in: Nature, Issue 623, 2023, Page(s) 1062-1069, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-06726-w

Elucidating the role of water in collagen self-assembly by isotopically modulating collagen hydration

Author(s): Giulia Giubertoni, Liru Feng, Kevin Klein, Guido Giannetti, Luco Rutten, Yeji Choi, Anouk van der Net, Gerard Castro-Linares, Federico Caporaletti, Dimitra Micha, Johannes Hunger, Antoine Deblais, Daniel Bonn, Nico Sommerdijk, Andela Šarić, Ioana M. Ilie, Gijsje H. Koenderink, Sander Woutersen
Published in: Proceedings of the National Academy of Sciences, Issue 121, 2024, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2313162121

Dynamic Clustering Regulates Activity of Mechanosensitive Membrane Channels

Author(s): Alexandru Paraschiv, Smitha Hegde, Raman Ganti, Teuta Pilizota, Anđela Šarić
Published in: Physical Review Letters, Issue 124/4, 2020, ISSN 0031-9007
Publisher: American Physical Society
DOI: 10.1103/physrevlett.124.048102

Wrapping pathways of anisotropic dumbbell particles by Giant Unilamellar Vesicles

Author(s): Azadbakht A, Meadowcroft B, Varkevisser T, Šarić A, Kraft DJ
Published in: Nano Letters, Issue 23(10), 2023, Page(s) 4267–4273, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.3c00375

Self-replication of A <i>β</i> ₄₂ aggregates occurs on small and isolated fibril sites

Author(s): Samo Curk, Johannes Krausser, Georg Meisl, Daan Frenkel, Sara Linse, Thomas C. T. Michaels, Tuomas P. J. Knowles, Anđela Šarić
Published in: Proceedings of the National Academy of Sciences, Issue 121, 2024, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2220075121

Nonadditivity in interactions between three membrane-wrapped colloidal spheres

Author(s): Ali Azadbakht, Billie Meadowcroft, Juraj Májek, Anđela Šarić, Daniela J. Kraft
Published in: Biophysical Journal, Issue 123, 2024, Page(s) 307-316, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2023.12.020

Modelling membrane reshaping by staged polymerization of ESCRT-III filaments

Author(s): Jiang X, Harker-Kirschneck L, Vanhille-Campos CE, Pfitzner A-K, Lominadze E, Roux A, Baum B, Šarić A
Published in: PLOS Computational Biology, Issue vol. 18, no. 10, 2022, Page(s) e1010586, ISSN 1553-7358
Publisher: Public Library of Science
DOI: 10.1371/journal.pcbi.1010586

Durotaxis of passive nanoparticles on elastic membranes

Author(s): Ivan Palaia; Alexandru Paraschiv; Vincent E. Debets; Cornelis Storm; Anđela Šarić
Published in: ACS Nano, 15(10), 15794 - 15802. American Chemical Society, Issue 1, 2021, ISSN 1936-086X
Publisher: American Chemical Society
DOI: 10.1101/2021.04.01.438065

The patterned assembly and stepwise Vps4-mediated disassembly of composite ESCRT-III polymers drives archaeal cell division

Author(s): Hurtig F, Burgers TCQ, Cezanne A, Jiang X, Mol FN, Traparić J, Pulschen AA, Nierhaus T, Tarrason-Risa G, Harker-Kirschneck L, Löwe J, Šarić A, Vlijm R, Baum B
Published in: Science Advances, Issue 9(11), 2023, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.ade5224

Modelling the dynamics of vesicle reshaping and scission under osmotic shocks

Author(s): Christian Vanhille-Campos, Anđela Šarić
Published in: Soft Matter, Issue 17/14, 2021, Page(s) 3798-3806, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sm02012e

Steering self-organisation through confinement

Author(s): Araújo NAM, Janssen LMC, Barois T, Boffetta G, Cohen I, Corbetta A, Dauchot O, Dijkstra M, Durham WM, Dussutour A, Garnier S, Gelderblom H, Golestanian R, Isa L, Koenderink GH, Löwen H, Metzler R, Polin M, Royall CP, Šarić A, Sengupta A, Sykes C, Trianni V, Tuval I, Vogel N, Yeomans JM, Zuriguel I, Marin A, Volpe G
Published in: Soft Matter, Issue 19, 2023, Page(s) 1695-1704, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2sm01562e

Self-organization of mortal filaments and its role in bacterial division ring formation

Author(s): Christian Vanhille-Campos, Kevin D. Whitley, Philipp Radler, Martin Loose, Séamus Holden, Anđela Šarić
Published in: Nature Physics, Issue 20, 2024, Page(s) 1670-1678, ISSN 1745-2473
Publisher: Nature Publishing Group
DOI: 10.1038/s41567-024-02597-8

Endosomal membrane budding patterns in plants

Author(s): Ethan Weiner, Elizabeth Berryman, Felix Frey, Ariadna González Solís, André Leier, Tatiana Marquez Lago, Anđela Šarić, Marisa S. Otegui
Published in: Proceedings of the National Academy of Sciences, Issue 121, 2024, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2409407121