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Predicting cardiovascular regeneration: integrating mechanical cues and signaling pathways

Project description

An advanced cardiovascular regeneration approach

Each year cardiovascular disease causes over 1.8 million deaths in the EU alone. The EU-funded MechanoSignaling project will explore cardiovascular regeneration with the aim of re-establishing physiological tissue organisation for proper tissue functionality. Previous attempts to establish this organisation have been mainly based on trial-and-error. To achieve its goal, the project will perform quantitative in vitro experiments to inform novel multiscale computational models of Notch signalling and its consequences on regeneration. The aim is to obtain a mechanistic understanding of how critical pathways in the cardiovascular system (such as the Notch signalling pathway) drive the emergence of tissue organisation.

Host institution

TECHNISCHE UNIVERSITEIT EINDHOVEN
Net EU contribution
€ 1 498 526,00
Address
Groene Loper 3
5612 AE Eindhoven
Netherlands

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Region
Noord-Brabant Zuidoost-Noord-Brabant
Activity type
Higher or Secondary Education Establishments
Other funding
€ 1 498 526,00

Beneficiaries (1)

TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands
Net EU contribution
€ 1 498 526,00
Address
Groene Loper 3
5612 AE Eindhoven

See on map

Region
Noord-Brabant Zuidoost-Noord-Brabant
Activity type
Higher or Secondary Education Establishments
Other funding
€ 1 498 526,00