Predicting cardiovascular regeneration: integrating mechanical cues and signaling pathways

Project Information

MechanoSignaling

Grant agreement ID: 802967

DOI

10.3030/802967

EC signature date 9 October 2018

Start date 1 January 2019

End date 31 January 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 498 526,00

EU contribution

€ 1 498 526,00

Coordinated by

TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

Mechano-regulated cell-cell signaling in the context of cardiovascular tissue engineering

Author(s): Cansu Karakaya, Jordy G.M. van Asten, Tommaso Ristori, Cecilia M Sahlgren, Sandra Loerakker
Published in: Biomechanics and Modeling in Mechanobiology, Issue 21/1, 2022, Page(s) 5-54, ISSN 1617-7959
Publisher: Springer Verlag
DOI: 10.1007/s10237-021-01521-w

Implementing computational modeling in tissue engineering: where disciplines meet

Author(s): Janine N. Post, Sandra Loerakker, Roeland M.H. Merks, Aurélie Carlier
Published in: Tissue Engineering Part A, Issue 28, 2022, Page(s) 542-554, ISSN 1937-3341
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tea.2021.0215

Computational analysis of heart valve growth and remodeling after the Ross procedure

Author(s): Elmer Middendorp, Fabian Braeu, Frank P. T. Baaijens, Jay D. Humphrey, Christian J. Cyron, Sandra Loerakker
Published in: Biomechanics and Modeling in Mechanobiology, Issue 23, 2024, Page(s) 1889-1907, ISSN 1617-7959
Publisher: Springer Verlag
DOI: 10.1007/s10237-024-01874-y

A multiscale computational model of arterial growth and remodeling including Notch signaling

Author(s): Jordy G.M. van Asten, Marcos Latorre, Cansu Karakaya, Frank P.T. Baaijens, Cecilia M. Sahlgren, Tommaso Ristori, Jay D. Humphrey, Sandra Loerakker
Published in: Biomechanics and Modeling in Mechanobiology, 2023, ISSN 1617-7959
Publisher: Springer Verlag
DOI: 10.1007/s10237-023-01697-3

Lateral induction limits the impact of cell connectivity on Notch signaling in arterial walls

Author(s): Tommaso Ristori, Oscar M. J. A. Stassen, Cecilia M. Sahlgren, Sandra Loerakker
Published in: International Journal for Numerical Methods in Biomedical Engineering, Issue 36/4, 2020, Page(s) e3323, ISSN 2040-7939
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cnm.3323

Computational modeling for cardiovascular tissue engineering: the importance of including cell behavior in growth and remodeling algorithms

Author(s): Sandra Loerakker, Tommaso Ristori
Published in: Current Opinion in Biomedical Engineering, Issue 15, 2020, Page(s) 1-9, ISSN 2468-4511
Publisher: Elsevier
DOI: 10.1016/j.cobme.2019.12.007

Computational analysis of the role of mechanosensitive Notch signaling in arterial adaptation to hypertension

Author(s): Jordy G.M. van Asten; Tommaso Ristori; David R. Nolan; Caitríona Lally; Frank P.T. Baaijens; Cecilia M. Sahlgren; Sandra Loerakker
Published in: Journal of the Mechanical Behavior of Biomedical Materials, Issue 133, 2022, Page(s) 105325, ISSN 1751-6161
Publisher: Elsevier BV
DOI: 10.1016/j.jmbbm.2022.105325

Computational modelling to reduce outcome variability in tissue-engineered heart valves

Author(s): Valery L Visser, Polina Zaytseva, Sarah E Motta, Sandra Loerakker, Simon P Hoerstrup, Maximilian Y Emmert
Published in: European Heart Journal, Issue 42/23, 2021, Page(s) 2225-2229, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehab034

Computer model-driven design in cardiovascular regenerative medicine

Author(s): Sandra Loerakker, Jay D. Humphrey
Published in: Annals of Biomedical Engineering, Issue 51, 2023, Page(s) 45-57, ISSN 0090-6964
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10439-022-03037-5

Notch signaling regulates strain-mediated phenotypic switching of vascular smooth muscle cells

Author(s): Cansu Karakaya; Mark C. van Turnhout; Valery L. Visser; Tommaso Ristori; Carlijn V. C. Bouten; Cecilia M. Sahlgren; Sandra Loerakker
Published in: Frontiers in Cell and Developmental Biology, Issue 10, 2022, Page(s) 910503, ISSN 2296-634X
Publisher: Frontiers Media SA
DOI: 10.3389/fcell.2022.910503

Geometry influences inflammatory host cell response and remodeling in tissue-engineered heart valves in-vivo

Author(s): Sarah E. Motta, Emanuela S. Fioretta, Valentina Lintas, Petra E. Dijkman, Monika Hilbe, Laura Frese, Nikola Cesarovic, Sandra Loerakker, Frank P. T. Baaijens, Volkmar Falk, Simon P. Hoerstrup, Maximilian Y. Emmert
Published in: Scientific Reports, Issue 10/1, 2020, Page(s) 19882, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-76322-9

Next-generation tissue-engineered heart valves with repair, remodelling and regeneration capacity

Author(s): Emanuela S. Fioretta, Sarah E. Motta, Valentina Lintas, Sandra Loerakker, Kevin K. Parker, Frank P. T. Baaijens, Volkmar Falk, Simon P. Hoerstrup, Maximilian Y. Emmert
Published in: Nature Reviews Cardiology, Issue 18/2, 2021, Page(s) 92-116, ISSN 1759-5002
Publisher: Nature Publishing Group
DOI: 10.1038/s41569-020-0422-8