Erasing the superintegron to understand the role of chromosomal integrons in bacterial evolution

Project Information

KryptonInt

Grant agreement ID: 803375

DOI

10.3030/803375

Project closed

EC signature date 9 November 2018

Start date 1 January 2019

End date 30 April 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 516,00

EU contribution

€ 1 499 516,00

Coordinated by

UNIVERSIDAD COMPLUTENSE DE MADRID
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (11)

Profile and resistance levels of 136 integron resistance genes

Author(s): Alberto Hipólito, Lucía García-Pastor, Ester Vergara, Thomas Jové, José Antonio Escudero
Published in: npj Antimicrobials and Resistance, Issue 1, 2023, Page(s) https://www.nature.com/articles/s44259-023-00014-3, ISSN 2731-8745
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44259-023-00014-3

Mobile integrons encode phage defense systems

Author(s): Nicolas Kieffer, Alberto Hipólito, Laura Ortiz-Miravalles, Paula Blanco, Thomas Delobelle, Patricia Vizuete, Francisco Manuel Ojeda, Thomas Jové, Dukas Jurenas, Meritxell García-Quintanilla, André Carvalho, Pilar Domingo-Calap, José Antonio Escudero
Published in: Science, Issue 388, 2025, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.ads0915

The expression of integron arrays is shaped by the translation rate of cassettes

Author(s): André Carvalho, Alberto Hipólito, Filipa Trigo da Roza, Lucía García-Pastor, Ester Vergara, Aranzazu Buendía, Teresa García-Seco, José Antonio Escudero
Published in: bioRxiv 2024, 2025, ISSN 2692-8205
Publisher: Nature Portfolio (Springer Nature)
DOI: 10.1101/2024.03.26.586746

Off-Target Integron Activity Leads to Rapid Plasmid Compensatory Evolution in Response to Antibiotic Selection Pressure

Author(s): Célia Souque, José A. Escudero, R. Craig MacLean
Published in: mBio, Issue 14, 2024, ISSN 2150-7511
Publisher: American Society for Microbiology
DOI: 10.1128/mbio.02537-22

Integron activity accelerates the evolution of antibiotic resistance

Author(s): Célia Souque, José Antonio Escudero, R Craig MacLean
Published in: eLife, Issue 10, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.62474

Chromosomal integrons are genetically and functionally isolated units of genomes

Author(s): Paula Blanco, Filipa Trigo da Roza, Laura Toribio-Celestino, Lucía García-Pastor, Niccolò Caselli, Álvaro Morón, Francisco Ojeda, Baptiste Darracq, Ester Vergara, Francisco Amaro, Álvaro San Millán, Ole Skovgaard, Didier Mazel, Céline Loot, José Antonio Escudero
Published in: Nucleic Acids Research, Issue 52, 2025, Page(s) 12565-12581, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkae866

A rugged yet easily navigable fitness landscape of antibiotic resistance

Author(s): Andrei Papkou, Lucia Garcia-Pastor, José Antonio Escudero, Andreas Wagner
Published in: bioRxiv, 2023, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.02.27.530293

Identification of Promoter Activity in Gene-Less Cassettes from<i>Vibrionaceae</i>Superintegrons

Author(s): Paula Blanco, Alberto Hipólito, Lucía García-Pastor, Filipa Trigo da Roza, Laura Toribio-Celestino, Alba Cristina Ortega, Ester Vergara, Álvaro San Millán, José Antonio Escudero
Published in: bioRxiv, 2023, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.11.21.568050

The expression of aminoglycoside resistance genes in integron cassettes is not controlled by riboswitches

Author(s): Alberto Hipólito, Lucía García-Pastor, Paula Blanco, Filipa Trigo da Roza, Nicolas Kieffer, Ester Vergara, Thomas Jové, Julio Álvarez, José Antonio Escudero
Published in: Nucleic Acids Research, Issue 50, 2022, Page(s) 8566-8579, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkac662

Identification of promoter activity in gene-less cassettes from <i>Vibrionaceae</i> superintegrons

Author(s): Paula Blanco, Alberto Hipólito, Lucía García-Pastor, Filipa Trigo da Roza, Laura Toribio-Celestino, Alba Cristina Ortega, Ester Vergara, Álvaro San Millán, José Antonio Escudero
Published in: Nucleic Acids Research, Issue 52, 2024, Page(s) 2961-2976, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkad1252

Primary and promiscuous functions coexist during evolutionary innovation through whole protein domain acquisitions

Author(s): José Antonio Escudero, Aleksandra Nivina, Harry E Kemble, Céline Loot, Olivier Tenaillon, Didier Mazel
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.58061

Intellectual Property Rights

Patent (3)

Vibrio cholerae strains to capture integron cassettes (Machine-translation by Google Translate, not legally binding)

Application/Publication number: 20 2330947
Date: 2023-11-16
Applicant(s): UNIVERSIDAD COMPLUTENSE DE MADRID

Tool for capturing integron cassettes (Machine-translation by Google Translate, not legally binding)

Application/Publication number: 20 2430387
Date: 2024-05-16
Applicant(s): UNIVERSIDAD COMPLUTENSE DE MADRID

Platform to capture integron cassettes (Machine-translation by Google Translate, not legally binding)

Application/Publication number: 20 2330912
Date: 2023-11-08
Applicant(s): UNIVERSIDAD COMPLUTENSE DE MADRID