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Erasing the superintegron to understand the role of chromosomal integrons in bacterial evolution

Project description

Insight into mobile genetic elements in bacteria: lessons from cholera

Bacterial genetic elements such as integrons are responsible for bacterial evolution through the transfer of genes. Mobile integrons are implicated in the emergence of antibiotic resistance that has become a major health challenge. Scientists of the EU-funded KryptonInt project are investigating the superintegron (SI), a sedentary chromosomal integron (SCI) located in the chromosome of Vibrio cholerae, the causative agent of Cholera disease. By deleting the SI, researchers will study the role and adaptive value of integrons in nature and look into the mechanism underlying gene excision into a mobile genetic element. Results will disclose important information on the distribution of antibiotic resistance elements among humans, animals, food, and the environment.

Host institution

UNIVERSIDAD COMPLUTENSE DE MADRID
Net EU contribution
€ 1 499 516,00
Address
Avenida De Seneca 2
28040 Madrid
Spain

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Higher or Secondary Education Establishments
Other funding
€ 1 499 516,00

Beneficiaries (1)

UNIVERSIDAD COMPLUTENSE DE MADRID
Spain
Net EU contribution
€ 1 499 516,00
Address
Avenida De Seneca 2
28040 Madrid

See on map

Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Higher or Secondary Education Establishments
Other funding
€ 1 499 516,00