Regulation of synaptic development and plasticity by molecular pathways linked to human evolution

Project Information

SYNPATH

Grant agreement ID: 803704

DOI

10.3030/803704

Project closed

EC signature date 11 December 2018

Start date 1 June 2019

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

Participation in the Open Research Data Pilot

Publications

Peer reviewed articles (9)

Unique properties of dually innervated dendritic spines in pyramidal neurons of the somatosensory cortex uncovered by 3D correlative light and electron microscopy

Author(s): Olivier Gemin; Pablo Serna; Joseph Zamith; Nora Assendorp; Matteo Fossati; Philippe Rostaing; Antoine Triller; Cécile Charrier
Published in: https://hal.sorbonne-universite.fr/hal-03350037, Issue 2, 2021, ISSN 1544-9173
Publisher: Public Library of Science
DOI: 10.1371/journal.pbio.3001375

Trans-synaptic interactions of ionotropic glutamate receptors

Author(s): Matteo Fossati, Cécile Charrier
Published in: Current Opinion in Neurobiology, 2021, ISSN 0959-4388
Publisher: Elsevier BV
DOI: 10.1016/j.conb.2020.09.001

Trans-synaptic functions of non-canonical ionotropic glutamate receptors in circuit wiring and plasticity

Author(s): Doris Wennagel, Cécile Charrier
Published in: Current Opinion in Neurobiology, Issue 93, 2025, Page(s) 103053, ISSN 0959-4388
Publisher: Elsevier BV
DOI: 10.1016/j.conb.2025.103053

Synaptic neoteny of human cortical neurons requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition

Author(s): Baptiste Libé-Philippot, Ryohei Iwata, Aleksandra J. Recupero, Keimpe Wierda, Sergio Bernal Garcia, Luke Hammond, Anja van Benthem, Ridha Limame, Martyna Ditkowska, Sofie Beckers, Vaiva Gaspariunaite, Eugénie Peze-Heidsieck, Daan Remans, Cécile Charrier, Tom Theys, Franck Polleux, Pierre Vanderhaeghen
Published in: Neuron, Issue 112, 2024, Page(s) 3602-3617.e9, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2024.08.021

GluD1 binds GABA and controls inhibitory plasticity

Author(s): Laura Piot, Christina Heroven, Simon Bossi, Joseph Zamith, Tomas Malinauskas, Chris Johnson, Doris Wennagel, David Stroebel, Cécile Charrier, A. Radu Aricescu, Laetitia Mony, Pierre Paoletti
Published in: Science, Issue 382, 2024, Page(s) 1389-1394, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adf3406

CTNND2 moderates the pace of synaptic maturation and links human evolution to synaptic neoteny

Author(s): Nora Assendorp, Matteo Fossati, Baptiste Libé-Philippot, Eirini Christopoulou, Marine Depp, Roberta Rapone, Florent Dingli, Damarys Loew, Pierre Vanderhaeghen, Cécile Charrier
Published in: Cell Reports, Issue 43, 2025, Page(s) 114797, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2024.114797

Molecular mechanisms of the specialization of human synapses in the neocortex

Author(s): Eirini Christopoulou, Cécile Charrier
Published in: Current Opinion in Genetics & Development, Issue 89, 2024, Page(s) 102258, ISSN 0959-437X
Publisher: Elsevier BV
DOI: 10.1016/j.gde.2024.102258

Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons

Author(s): Matteo Fossati, Nora Assendorp, Olivier Gemin, Sabrina Colasse, Florent Dingli, Guillaume Arras, Damarys Loew, Cécile Charrier
Published in: Neuron, 2019, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2019.09.027

Optochemical profiling of NMDAR molecular diversity at synaptic and extrasynaptic sites

Author(s): Antoine Sicard, Meilin Tian, Zakaria Mostefai, Sophie Shi, Cécile Cardoso, Joseph Zamith, Isabelle McCort-Tranchepain, Cécile Charrier, Pierre Paoletti, Laetitia Mony
Published in: The EMBO Journal, 2025, ISSN 1460-2075
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44318-025-00498-x

Thesis and dissertations (1)

Morphometric analysis and modeling of spines on basal dendrites of pyramidal neurons in layers 2-3 of the somato-sensory cortex : a correlative light-electron microscopy study

Author(s): Gemin, Olivier
Published in: https://tel.archives-ouvertes.fr/tel-02942738, Issue 2, 2020
Publisher: NA