A need for speed: mechanisms to coordinate protein synthesis and folding in metazoans

Project Information

TransTempoFold

Grant agreement ID: 803825

DOI

10.3030/803825

Project closed

EC signature date 16 November 2018

Start date 1 January 2019

End date 31 March 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

High-resolution quantitative profiling of tRNA abundance and modification status in eukaryotes by mim-tRNAseq

Author(s): Andrew Behrens, Geraldine Rodschinka, Danny D. Nedialkova
Published in: Molecular Cell, Issue 81/8, 2021, Page(s) 1802-1815.e7, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2021.01.028

The dynamics and functional impact of tRNA repertoires during early embryogenesis in zebrafish

Author(s): Madalena M Reimão-Pinto, Andrew Behrens, Sergio Forcelloni, Klemens Fröhlich, Selay Kaya, Danny D Nedialkova
Published in: The EMBO Journal, Issue 43, 2024, Page(s) 5747-5779, ISSN 1460-2075
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44318-024-00265-4

Altered translation elongation contributes to key hallmarks of aging in the killifish brain

Author(s): Domenico Di Fraia, Antonio Marino, Jae Ho Lee, Erika Kelmer Sacramento, Mario Baumgart, Sara Bagnoli, Till Balla, Felix Schalk, Stephan Kamrad, Rui Guan, Cinzia Caterino, Chiara Giannuzzi, Pedro Tomaz da Silva, Amit Kumar Sahu, Hanna Gut, Giacomo Siano, Max Tiessen, Eva Terzibasi-Tozzini, Eugenio F. Fornasiero, Julien Gagneur, Christoph Englert, Kiran R. Patil, Clara Correia-Melo, Danny D. Nedialk
Published in: Science, Issue 389, 2025, Page(s) (6759):eadk3079, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adk3079

Experimental and computational workflow for the analysis of tRNA pools from eukaryotic cells by mim-tRNAseq.

Author(s): Behrens, A., Nedialkova D.D.
Published in: Star Protocols, Issue 3/3, 2022, Page(s) 101579, ISSN 2666-1667
Publisher: Cell Press
DOI: 10.1016/j.xpro.2022.101579

<i>ADAT3</i> variants disrupt the activity of the ADAT tRNA deaminase complex and impair neuronal migration

Author(s): Jordi Del-Pozo-Rodriguez, Peggy Tilly, Romain Lecat, Hugo Rolando Vaca, Laureline Mosser, Elena Brivio, Till Balla, Marina Vitoria Gomes, Elizabeth Ramos-Morales, Noémie Schwaller, Thalia Salinas-Giegé, Grace VanNoy, Eleina M England, Alysia Kern Lovgren, Melanie O’Leary, Maya Chopra, Naomi Meave Ojeda, Mehran Beiraghi Toosi, Atieh Eslahi, Masoome Alerasool, Majid Mojarrad, Lynn S Pais, Rebecc
Published in: Brain, 2025, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awaf109

Selective gene expression maintains human tRNA anticodon pools during differentiation

Author(s): Lexi Gao, Andrew Behrens, Geraldine Rodschinka, Sergio Forcelloni, Sascha Wani, Katrin Strasser, Danny D. Nedialkova
Published in: Nature Cell Biology, Issue 26, 2024, Page(s) 100-112, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-023-01317-3

Comparative CRISPRi screens reveal a human stem cell dependence on mRNA translation-coupled quality control

Author(s): Geraldine Rodschinka, Sergio Forcelloni, Felix M. Kühner, Sascha Wani, Henrick Riemenschneider, Dieter Edbauer, Andrew Behrens, Danny D. Nedialkova
Published in: Nature Structural &amp; Molecular Biology, 2025, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-025-01616-3

Correcting a pathogenic mitochondrial DNA mutation by base editing in mice

Author(s): Jose D. Barrera-Paez, Sandra R. Bacman, Till Balla, Derek Van Booven, Durga P. Gannamedi, James B. Stewart, Beverly Mok, David R. Liu, David B. Lombard, Anthony J. Griswold, Danny D. Nedialkova, Carlos T. Moraes
Published in: Science Translational Medicine, Issue 17, 2025, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.adr0792

RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks

Author(s): Shubo Zhao, Jacqueline Cordes, Karolina M. Caban, Maximilian J. Götz, Timur Mackens-Kiani, Anthony J. Veltri, Niladri K. Sinha, Pedro Weickert, Selay Kaya, Graeme Hewitt, Danny D. Nedialkova, Thomas Fröhlich, Roland Beckmann, Allen R. Buskirk, Rachel Green, Julian Stingele
Published in: Molecular Cell, Issue 83, 2024, Page(s) 4290-4303.e9, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2023.10.012

Intellectual Property Rights

Other (2)

Method for cDNA library construction and analysis from transfer RNA

Application/Publication number: PCT/ EP2021/072902
Date: 2021-08-18
Applicant(s): MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Method for cDNA library construction and analysis from transfer RNA

Application/Publication number: PCT/ EP2021/072902
Date: 2021-08-18
Applicant(s): MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV