Homologous recombination and its application in manipulating animal mitochondrial DNA

Project Information

Mito-recombine

Grant agreement ID: 803852

DOI

10.3030/803852

Project closed

EC signature date 26 September 2018

Start date 1 March 2019

End date 31 December 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 473 732,00

EU contribution

€ 1 473 732,00

Coordinated by

THE UNIVERSITY OF BIRMINGHAM
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

Two mitochondrial DNA polymorphisms modulate cardiolipin binding and lead to synthetic lethality

Author(s): Ason C. Y. Chiang, Jan Ježek, Peiqiang Mu, Ying Di, Anna Klucnika, Martin Jabůrek, Petr Ježek, Hansong Ma
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-44964-2

Milton assembles large mitochondrial clusters, mitoballs, to sustain spermatogenesis

Author(s): Andy Y Z Li, Ying Di, Sumaera Rathore, Ason C-Y Chiang, Jan Jezek, Hansong Ma
Published in: Proc Natl Acad Sci U S A ., Issue Vol. 120 No. 34 e2306073120, 2023, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2306073120

Mapping and editing animal mitochondrial genomes: can we overcome the challenges?

Author(s): Anna Klucnika, Hansong Ma
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, Issue 375, 2022, Page(s) 20190187, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2019.0187

REC drives recombination to repair double-strand breaks in animal mtDNA

Author(s): Anna Klucnika; Peiqiang Mu; Jan Jezek; Matthew McCormack; Ying Di; Charles R. Bradshaw; Hansong Ma
Published in: Journal of Cell Biology, Issue 1, 2022, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202201137

A Genome-wide Screen Reveals that Reducing Mitochondrial DNA Polymerase Can Promote Elimination of Deleterious Mitochondrial Mutations

Author(s): Ason C.-Y. Chiang, Eleanor McCartney, Patrick H. O'Farrell, Hansong Ma
Published in: Current Biology, Issue 29, 2025, Page(s) 4330-4336.e3, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2019.10.060

Mitochondrial heteroplasmy beyond the oocyte bottleneck

Author(s): Jelle van den Ameele, Andy Y.Z. Li, Hansong Ma, Patrick F. Chinnery
Published in: Seminars in Cell & Developmental Biology, Issue 97, 2025, Page(s) 156-166, ISSN 1084-9521
Publisher: Academic Press
DOI: 10.1016/j.semcdb.2019.10.001

Replication competition drives the selective mtDNA inheritance in <i>Drosophila</i> ovary

Author(s): Cheng Zhang, Zhe Chen, Hansong Ma, Hong Xu
Published in: Cell Reports, 2026, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1101/2025.04.29.650984

Poldip2 promotes mtDNA elimination during Drosophila spermatogenesis to ensure maternal inheritance

Author(s): Ziming Wang, Tirawit Meerod, Nuria Cortes-Silva, Ason C-Y Chiang, Ziyan Nie, Ying Di, Peiqiang Mu, Ankit Verma, Adam James Reid, Hansong Ma
Published in: The EMBO Journal, Issue 44, 2025, Page(s) 1724-1748, ISSN 1460-2075
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44318-025-00378-4

Single-molecule mitochondrial DNA imaging reveals heteroplasmy dynamics shaped by developmental bottlenecks and selection in different organs in vivo

Author(s): Rajini Chandrasegaram, Antony M. Hynes-Allen, Beitong Gao, Abhilesh Dhawanjewar, Michele Frison, Stavroula Petridi, Patrick F. Chinnery, Hansong Ma, Jelle van den Ameele
Published in: Developmental Cell, 2026, ISSN 0000-0000
Publisher: Cell Press