Molecular mechanisms of cortical interneuron development
Abnormal neuronal differentiation can result in a variety of neuropsychiatric disorders, including epilepsy, autism, bipolar disorder and schizophrenia. Cortical interneurons are a diverse class of inhibitory neurons that are important for the stability of the neural circuits underlying cognitive and higher-order brain functions. The EU-funded GIDE project will investigate whether neurodevelopmental trajectories are predetermined by particular progenitors during mitotic stages or emerge later in the development process through interactions with the environment. The study will employ genetic fate-mapping, high-throughput single-cell RNA sequencing and molecular tagging techniques to gain a detailed understanding of neurogenesis at the cellular level. Furthermore, the researchers will focus on the genetic mechanisms that determine cell fate regulation by environmental processes during postnatal development.
Fields of science
Call for proposalSee other projects for this call
Funding SchemeERC-STG - Starting Grant
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