Multiscale Mechanics of Bone Fragility in Type-2 Diabetes

Project Information

MULT2D

Grant agreement ID: 804108

DOI 10.3030/804108

EC signature date 30 October 2018

Start date 1 February 2019

End date 31 January 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 499 659,00

EU contribution € 1 499 659,00

Coordinated by

UNIVERSITY OF GALWAY
Ireland

Publications

Peer reviewed articles (8)

Longitudinal alterations in bone morphometry, mechanical integrity and composition in Type-2 diabetes in a Zucker diabetic fatty (ZDF) rat

Author(s): Genna E Monahan, Jessica Schiavi-Tritz, Marissa Britton, Ted J Vaughan
Published in: Bone, Issue 170, 2023, Page(s) 116678, ISSN 8756-3282
Publisher: Elsevier BV
DOI: 10.1016/j.bone.2023.116672

A multiscale finite element investigation on the role of intra- and extra-fibrillar mineralisation on the elastic properties of bone tissue

Author(s): Hamid Alijani, Ted J.Vaughan
Published in: Journal of the Mechanical Behavior of Biomedical Materials, Issue 129, 2022, Page(s) 105139, ISSN 1751-6161
Publisher: Elsevier BV
DOI: 10.1016/j.jmbbm.2022.105139

Bone Mineral Is More Heterogeneously Distributed in the Femoral Heads of Osteoporotic and Diabetic Patients: A Pilot Study

Author(s): Eoin Parle, Sherdya Tio, Annie Behre, John J Carey, Colin G Murphy, Timothy F O'Brien, William A Curtin, Stephen R Kearns, John P McCabe, Cynthia M Coleman, Ted J Vaughan, Laoise M McNamara
Published in: JBMR Plus, Issue 4/2, 2020, ISSN 2473-4039
Publisher: Wiley
DOI: 10.1002/jbm4.10253

An investigation on the effects of in vitro induced advanced glycation end-products on cortical bone fracture mechanics at fall-related loading rates

Author(s): Marissa Britton, Eoin Parle, Ted Vaughan
Published in: Journal of the Mechanical Behavior of Biomedical Materials, Issue 138, 2023, Page(s) 105619, ISSN 1751-6161
Publisher: Elsevier BV
DOI: 10.1016/j.jmbbm.2022.105619

The structural role of osteocalcin in bone biomechanics and its alteration in Type-2 Diabetes

Author(s): Mahdi Tavakol, Ted J. Vaughan
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-73141-w

Designing Hydrogel-Based Bone-On-Chips for Personalized Medicine

Author(s): Gabriele Nasello, Mar Cóndor, Ted Vaughan, Jessica Schiavi
Published in: Applied Sciences, Issue 11/10, 2021, Page(s) 4495, ISSN 2076-3417
Publisher: MDPI
DOI: 10.3390/app11104495

A coarse-grained molecular dynamics investigation of the role of mineral arrangement on the mechanical properties of mineralized collagen fibrils

Author(s): Mahdi Tavakol, Ted Vaughan
Published in: Journal of the Royal Society Interface, Issue 20, 2023, ISSN 1742-5689
Publisher: The Royal Society
DOI: 10.1098/rsif.2022.0803

Energy dissipation of osteopontin at a HAp mineral interface: Implications for bone biomechanics

Author(s): Mahdi Tavakol, Ted Vaughan
Published in: Biophysical Journal, Issue 121, 2022, Page(s) 228-236, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2021.12.023

Non-peer reviewed articles (1)

A morphological, topological and mechanical investigation of gyroid, spinodoid and dual-lattice algorithms as structural models of trabecular bone

Author(s): Mahtab Vafaeefar, Kevin M Moerman, Majid Kavousi, Ted J Vaughan
Published in: Journal of the Mechanical Behavior of Biomedical Materials, Issue 138, 2023, Page(s) 105584, ISSN 1751-6161
Publisher: Elsevier BV
DOI: 10.1016/j.jmbbm.2022.105584

Conference proceedings (1)

The role of the osteocalcin-osteopontin protein complex in bone biomechanics: a key contributor to energy dissipation at mineral-mineral interfaces

Author(s): Mahdi Tavakol, Ted Vaughan
Published in: Biophysical Journal, Issue 121, 2022, Page(s) 332A, ISSN 0006-3495
Publisher: Elsevier
DOI: 10.1016/j.bpj.2021.11.1113