Mucus-Penetrating Microbiota: Characterization, Mechanism and Therapeutic in Metabolic Disease

Publications

Peer reviewed articles (36)

Soluble Fiber Inulin Consumption Limits Alterations of the Gut Microbiota and Hepatic Fatty Acid Metabolism Caused by High-Fat Diet

Author(s): Mayssa Albouery, Alexis Bretin, Bénédicte Buteau, Stéphane Grégoire, Lucy Martine, Ségolène Gambert, Alain M. Bron, Niyazi Acar, Benoit Chassaing, Marie-Agnès Bringer
Published in: Nutrients, Issue 13/3, 2021, Page(s) 1037, ISSN 2072-6643
DOI: 10.3390/nu13031037

Adaptation of adherent-invasive E. coli to gut environment: Impact on flagellum expression and bacterial colonization ability

Author(s): Gwladys Sevrin, Sébastien Massier, Benoit Chassaing, Allison Agus, Julien Delmas, Jérémy Denizot, Elisabeth Billard, Nicolas Barnich
Published in: Gut Microbes, Issue 11/3, 2020, Page(s) 364-380, ISSN 1949-0976
DOI: 10.1080/19490976.2017.1421886

Fecal dysbiosis associated with colonic hypersensitivity and behavioral alterations in chronically Blastocystis-infected rats

Author(s): Manon Defaye, Céline Nourrisson, Elodie Baudu, Amandine Lashermes, Maëva Meynier, Mathieu Meleine, Ivan Wawrzyniak, Virginie Bonnin, Julie Barbier, Benoit Chassaing, Catherine Godfraind, Agathe Gelot, Nicolas Barnich, Denis Ardid, Mathilde Bonnet, Frédéric Delbac, Frédéric Antonio Carvalho, Philippe Poirier
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
DOI: 10.1038/s41598-020-66156-w

Lipocalin 2 deficiency-induced gut microbiota dysbiosis evokes metabolic syndrome in aged mice

Author(s): Vishal Singh, Sarah Galla, Rachel M. Golonka, Andrew D. Patterson, Benoit Chassaing, Bina Joe, Matam Vijay-Kumar
Published in: Physiological Genomics, Issue 52/8, 2020, Page(s) 314-321, ISSN 1094-8341
DOI: 10.1152/physiolgenomics.00118.2019

Critical Role of Innate Immunity to Flagellin in the Absence of Adaptive Immunity

Author(s): Jun Zou, Xu Zhao, Zhenda Shi, Zhan Zhang, Matam Vijay-Kumar, Benoit Chassaing, Andrew T Gewirtz
Published in: The Journal of Infectious Diseases, Issue 223/8, 2020, Page(s) 1478-1487, ISSN 0022-1899
DOI: 10.1093/infdis/jiaa521

Inulin Fermentable Fiber Ameliorates Type I Diabetes via IL22 and Short-Chain Fatty Acids in Experimental Models

Author(s): Jun Zou, Lavanya Reddivari, Zhenda Shi, Shiyu Li, Yanling Wang, Alexis Bretin, Vu L. Ngo, Michael Flythe, Michael Pellizzon, Benoit Chassaing, Andrew T. Gewirtz
Published in: Cellular and Molecular Gastroenterology and Hepatology, 2021, ISSN 2352-345X
DOI: 10.1016/j.jcmgh.2021.04.014

Commensal epitopes drive differentiation of colonic T regs

Author(s): Michal P. Kuczma, Edyta A. Szurek, Anna Cebula, Benoit Chassaing, Yu-Jin Jung, Sang-Moo Kang, James G. Fox, Bärbel Stecher, Leszek Ignatowicz
Published in: Science Advances, Issue 6/16, 2020, Page(s) eaaz3186, ISSN 2375-2548
DOI: 10.1126/sciadv.aaz3186

Ingestion of probiotic (Lactobacillus helveticus and Bifidobacterium longum) alters intestinal microbial structure and behavioral expression following social defeat stress

Author(s): Katherine A. Partrick, Anna M. Rosenhauer, Jérémie Auger, Amanda R. Arnold, Nicole M. Ronczkowski, Lanaya M. Jackson, Magen N. Lord, Sara M. Abdulla, Benoit Chassaing, Kim L. Huhman
Published in: Scientific Reports, Issue 11/1, 2021, ISSN 2045-2322
DOI: 10.1038/s41598-021-83284-z

IL-22–induced cell extrusion and IL-18–induced cell death prevent and cure rotavirus infection

Author(s): Zhan Zhang, Jun Zou, Zhenda Shi, Benyue Zhang, Lucie Etienne-Mesmin, Yanling Wang, Xuyan Shi, Feng Shao, Benoit Chassaing, Andrew T. Gewirtz
Published in: Science Immunology, Issue 5/52, 2020, Page(s) eabd2876, ISSN 2470-9468
DOI: 10.1126/sciimmunol.abd2876

Amelioration of metabolic syndrome by metformin associates with reduced indices of low-grade inflammation independently of the gut microbiota

Author(s): Aneseh Adeshirlarijaney, Jun Zou, Hao Q. Tran, Benoit Chassaing, Andrew T. Gewirtz
Published in: American Journal of Physiology-Endocrinology and Metabolism, Issue 317/6, 2019, Page(s) E1121-E1130, ISSN 0193-1849
DOI: 10.1152/ajpendo.00245.2019

Enhanced E. coli LF82 Translocation through the Follicle-associated Epithelium in Crohn’s Disease is Dependent on Long Polar Fimbriae and CEACAM6 expression, and Increases Paracellular Permeability

Author(s): Åsa V Keita, Lina Yakymenko Alkaissi, Elin B Holm, Stéphanie D S Heil, Benoit Chassaing, Arlette Darfeuille-Michaud, Derek M McKay, Johan D Söderholm
Published in: Journal of Crohn's and Colitis, Issue 14/2, 2019, Page(s) 216-229, ISSN 1873-9946
DOI: 10.1093/ecco-jcc/jjz144

Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations

Author(s): Emilie Viennois, Adani Pujada, Junsik Sung, Chunhua Yang, Andrew T. Gewirtz, Benoit Chassaing, Didier Merlin
Published in: npj Biofilms and Microbiomes, Issue 6/1, 2020, ISSN 2055-5008
DOI: 10.1038/s41522-020-0137-y

“Western Diet”-Induced Adipose Inflammation Requires a Complex Gut Microbiota

Author(s): Hao Q. Tran, Alexis Bretin, Aneseh Adeshirlarijaney, Beng San Yeoh, Matam Vijay-Kumar, Jun Zou, Timothy L. Denning, Benoit Chassaing, Andrew T. Gewirtz
Published in: Cellular and Molecular Gastroenterology and Hepatology, Issue 9/2, 2020, Page(s) 313-333, ISSN 2352-345X
DOI: 10.1016/j.jcmgh.2019.09.009

Erythroid differentiation regulator-1 induced by microbiota in early life drives intestinal stem cell proliferation and regeneration

Author(s): Hirohito Abo, Benoit Chassaing, Akihito Harusato, Miguel Quiros, Jennifer C. Brazil, Vu L. Ngo, Emilie Viennois, Didier Merlin, Andrew T. Gewirtz, Asma Nusrat, Timothy L. Denning
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
DOI: 10.1038/s41467-019-14258-z

The TOTUM-63 Supplement and High-Intensity Interval Training Combination Limits Weight Gain, Improves Glycemic Control, and Influences the Composition of Gut Mucosa-Associated Bacteria in Rats on a High Fat Diet

Author(s): Marine Dupuit, Vivien Chavanelle, Benoit Chassaing, Fanny Perriere, Monique Etienne, Claire Plissonneau, Audrey Boscaro, Nicolas Barnich, Vincent Pialoux, Thierry Maugard, Florian Le Joubioux, Sébastien Peltier, Pascal Sirvent, Yolanda F. Otero, Nathalie Boisseau
Published in: Nutrients, Issue 13/5, 2021, Page(s) 1569, ISSN 2072-6643
DOI: 10.3390/nu13051569

Dietary Emulsifiers Directly Impact Adherent-Invasive E. coli Gene Expression to Drive Chronic Intestinal Inflammation

Author(s): Emilie Viennois, Alexis Bretin, Philip E. Dubé, Alexander C. Maue, Charlène J.G. Dauriat, Nicolas Barnich, Andrew T. Gewirtz, Benoit Chassaing
Published in: Cell Reports, Issue 33/1, 2020, Page(s) 108229, ISSN 2211-1247
DOI: 10.1016/j.celrep.2020.108229

A Listeria monocytogenes Bacteriocin Can Target the Commensal Prevotella copri and Modulate Intestinal Infection

Author(s): Nathalie Rolhion, Benoit Chassaing, Marie-Anne Nahori, Jana de Bodt, Alexandra Moura, Marc Lecuit, Olivier Dussurget, Marion Bérard, Massimo Marzorati, Hannah Fehlner-Peach, Dan R. Littman, Andrew T. Gewirtz, Tom Van de Wiele, Pascale Cossart
Published in: Cell Host & Microbe, Issue 26/5, 2019, Page(s) 691-701.e5, ISSN 1931-3128
DOI: 10.1016/j.chom.2019.10.016

Prognostic value of a combination of innovative factors (gut microbiota, sarcopenia, obesity, metabolic syndrome) to predict surgical/oncologic outcomes following surgery for sporadic colorectal cancer: a prospective cohort study protocol (METABIOTE)

Author(s): Julie Veziant, Karine Poirot, Caroline Chevarin, Lucie Cassagnes, Pierre Sauvanet, Benoit Chassaing, Frederic Robin, Catherine Godfraind, Nicolas Barnich, Denis Pezet, Bruno Pereira, Johan Gagniere, Mathilde Bonnet
Published in: BMJ Open, Issue 10/1, 2020, Page(s) e031472, ISSN 2044-6055
DOI: 10.1136/bmjopen-2019-031472

The Intestinal Microbiota: Our Best Frenemy in Radiation-Induced Damages?

Author(s): Melissa C. Kordahi, Benoit Chassaing
Published in: Cell Host & Microbe, Issue 29/1, 2021, Page(s) 7-9, ISSN 1931-3128
DOI: 10.1016/j.chom.2020.12.013

Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases

Author(s): Hao Q. Tran, Ruth E. Ley, Andrew T. Gewirtz, Benoit Chassaing
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-019-13538-y

Consumption of Select Dietary Emulsifiers Exacerbates the Development of Spontaneous Intestinal Adenoma

Author(s): Emilie Viennois, Benoit Chassaing
Published in: International Journal of Molecular Sciences, Issue 22/5, 2021, Page(s) 2602, ISSN 1422-0067
DOI: 10.3390/ijms22052602

High-Intensity Interval Training and α-Linolenic Acid Supplementation Improve DHA Conversion and Increase the Abundance of Gut Mucosa-Associated Oscillospira Bacteria

Author(s): Claire Plissonneau, Frederic Capel, Benoit Chassaing, Marine Dupuit, Florie Maillard, Ivan Wawrzyniak, Lydie Combaret, Frederic Dutheil, Monique Etienne, Guillaume Mairesse, Guillaume Chesneau, Nicolas Barnich, Nathalie Boisseau
Published in: Nutrients, Issue 13/3, 2021, Page(s) 788, ISSN 2072-6643
DOI: 10.3390/nu13030788

Beneficial Effects of Natural Mineral Waters on Intestinal Inflammation and the Mucosa-Associated Microbiota

Author(s): Nicolas Barnich, Michael Rodrigues, Pierre Sauvanet, Caroline Chevarin, Sylvain Denis, Olivier Le Goff, Danielle Faure-Imbert, Thierry Hanh, Christian F Roques, Benoit Chassaing, Monique Alric
Published in: International Journal of Molecular Sciences, Issue 22/9, 2021, Page(s) 4336, ISSN 1422-0067
DOI: 10.3390/ijms22094336

The intestinal microbiota regulates host cholesterol homeostasis

Author(s): Tiphaine Le Roy, Emelyne Lécuyer, Benoit Chassaing, Moez Rhimi, Marie Lhomme, Samira Boudebbouze, Farid Ichou, Júlia Haro Barceló, Thierry Huby, Maryse Guerin, Philippe Giral, Emmanuelle Maguin, Nathalie Kapel, Philippe Gérard, Karine Clément, Philippe Lesnik
Published in: BMC Biology, Issue 17/1, 2019, ISSN 1741-7007
DOI: 10.1186/s12915-019-0715-8

Direct impact of commonly used dietary emulsifiers on human gut microbiota

Author(s): Sabrine Naimi, Emilie Viennois, Andrew T. Gewirtz, Benoit Chassaing
Published in: Microbiome, Issue 9/1, 2021, ISSN 2049-2618
DOI: 10.1186/s40168-020-00996-6

Food Additive Emulsifiers and Their Impact on Gut Microbiome, Permeability, and Inflammation: Mechanistic Insights in Inflammatory Bowel Disease

Author(s): Aaron S Bancil, Alicia M Sandall, Megan Rossi, Benoit Chassaing, James O Lindsay, Kevin Whelan
Published in: Journal of Crohn's and Colitis, 2020, ISSN 1873-9946
DOI: 10.1093/ecco-jcc/jjaa254

Organ-level protein networks as a reference for the host effects of the microbiome

Author(s): Robert H. Mills, Jacob M. Wozniak, Alison Vrbanac, Anaamika Campeau, Benoit Chassaing, Andrew Gewirtz, Rob Knight, David J. Gonzalez
Published in: Genome Research, Issue 30/2, 2020, Page(s) 276-286, ISSN 1088-9051
DOI: 10.1101/gr.256875.119

Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation

Author(s): Vishal Singh, Beng San Yeoh, Rachel E Walker, Xia Xiao, Piu Saha, Rachel M Golonka, Jingwei Cai, Alexis Charles Andre Bretin, Xi Cheng, Qing Liu, Michael D Flythe, Benoit Chassaing, Gregory C Shearer, Andrew D Patterson, Andrew T Gewirtz, Matam Vijay-Kumar
Published in: Gut, Issue 68/10, 2019, Page(s) 1801-1812, ISSN 0017-5749
DOI: 10.1136/gutjnl-2018-316250

Segmented Filamentous Bacteria Prevent and Cure Rotavirus Infection

Author(s): Zhenda Shi, Jun Zou, Zhan Zhang, Xu Zhao, Juan Noriega, Benyue Zhang, Chunyu Zhao, Harshad Ingle, Kyle Bittinger, Lisa M. Mattei, Andrea J. Pruijssers, Richard K. Plemper, Timothy J. Nice, Megan T. Baldridge, Terence S. Dermody, Benoit Chassaing, Andrew T. Gewirtz
Published in: Cell, Issue 179/3, 2019, Page(s) 644-658.e13, ISSN 0092-8674
DOI: 10.1016/j.cell.2019.09.028

Vers un vaccin contre les maladies inflammatoires chroniques ?

Author(s): Sabrine Naimi, Benoit Chassaing
Published in: médecine/sciences, Issue 36/8-9, 2020, Page(s) 689-691, ISSN 0767-0974
DOI: 10.1051/medsci/2020137

Host/microbiota interactions in health and diseases—Time for mucosal microbiology!

Author(s): Noëmie Daniel, Emelyne Lécuyer, Benoit Chassaing
Published in: Mucosal Immunology, 2020, ISSN 1933-0219
DOI: 10.1038/s41385-021-00383-w

The Hidden Effect of Nod2 in the Host/Microbiota Relationship

Author(s): Noëmie Daniel, Benoit Chassaing
Published in: Cellular and Molecular Gastroenterology and Hepatology, Issue 10/2, 2020, Page(s) 424-425, ISSN 2352-345X
DOI: 10.1016/j.jcmgh.2020.05.001

Dietary fat and low fiber in purified diets differently impact the gut-liver axis to promote obesity-linked metabolic impairments

Author(s): Noëmie Daniel, Laίs Rossi Perazza, Thibault V. Varin, Jocelyn Trottier, Bruno Marcotte, Philippe St-Pierre, Olivier Barbier, Benoit Chassaing, André Marette
Published in: American Journal of Physiology-Gastrointestinal and Liver Physiology, Issue 320/6, 2021, Page(s) G1014-G1033, ISSN 0193-1857
DOI: 10.1152/ajpgi.00028.2021

Emulsifiers Impact Colonic Length in Mice and Emulsifier Restriction is Feasible in People with Crohn’s Disease

Author(s): Alicia M. Sandall, Selina R. Cox, James O. Lindsay, Andrew T. Gewirtz, Benoit Chassaing, Megan Rossi, Kevin Whelan
Published in: Nutrients, Issue 12/9, 2020, Page(s) 2827, ISSN 2072-6643
DOI: 10.3390/nu12092827

Tolerogenic Dendritic Cells Shape a Transmissible Gut Microbiota that Protects from Metabolic Diseases

Author(s): Emelyne Lécuyer, Tiphaine Le Roy, Aurélie Gestin, Amélie Lacombe, Catherine Philippe, Maharajah Ponnaiah, Jean-Baptiste Huré, Magali Fradet, Farid Ichou, Samira Boudebbouze, Thierry Huby, Emmanuel Gautier, Moez Rhimi, Emmanuelle Maguin, Nathalie Kapel, Philippe Gérard, Nicolas Venteclef, Michéle Garlatti, Benoit Chassaing, Philippe Lesnik
Published in: Diabetes, 2021, Page(s) db201177, ISSN 0012-1797
DOI: 10.2337/db20-1177

Impact of a high-fat diet on the fatty acid composition of the retina

Author(s): Mayssa Albouery, Bénédicte Buteau, Stéphane Grégoire, Lucy Martine, Ségolène Gambert, Alain M. Bron, Niyazi Acar, Benoit Chassaing, Marie-Agnès Bringer
Published in: Experimental Eye Research, Issue 196, 2020, Page(s) 108059, ISSN 0014-4835
DOI: 10.1016/j.exer.2020.108059