The asymmetry of life: towards a unified view of the emergence of biological homochirality

Project Information

A-LIFE

Grant agreement ID: 804144

DOI

10.3030/804144

Project closed

EC signature date 7 September 2018

Start date 1 April 2019

End date 30 September 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (23)

Molecular Diversity and Amino Acid Evolution in Simulated Carbonaceous Chondrite Parent Bodies

Author(s): Adeline Garcia, Yingfei Yan, Cornelia Meinert, Philippe Schmitt-Kopplin, Vassilissa Vinogradoff, Jean-Christophe Viennet, Laurent Remusat, Sylvain Bernard, Michel Righezza, Louis Le Sergeant d’Hendecourt, Grégoire Danger
Published in: ACS Earth and Space Chemistry, Issue 8, 2024, Page(s) 606-615, ISSN 2472-3452
Publisher: American Chemical Society
DOI: 10.1021/acsearthspacechem.3c00366

Rosetta et ExoMars sur les traces des origines moléculaires de la vie

Author(s): Guillaume Leseigneur , Adrien D. Garcia , Cornelia Meinert , Louis Le Sergeant d’Hendecourt , Uwe J. Meierhenrich
Published in: L’Actualité Chimique, Issue 455, 2020, Page(s) 17-23, ISSN 0151-9093
Publisher: Societe Francaise de Chimie

Gas chromatography coupled-to Fourier transform orbitrap mass spectrometer for enantioselective amino acid analyses: application to pre-cometary organic analog.

Author(s): Garcia A, Serra C, Blancart Remaury Q, Garcia AD, Righezza M, Meinert C, Poinot P, Danger G.
Published in: Journal of Chromatography A, Issue 1704, 2023, Page(s) 464118, ISSN 0021-9673
Publisher: Elsevier BV
DOI: 10.1016/j.chroma.2023.464118

Amino acid gas phase circular dichroism and implications for the origin of biomolecular asymmetry

Author(s): Cornelia Meinert, Adrien Garcia, Jérémie Topin, Nykola Jones, Mira Diekmann, Robert Berger, Laurent Nahon, Søren V. Hoffmann, Uwe J. Meierhenrich
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-28184-0

Concentration and pH effect on the electronic circular dichroism and anisotropy spectra of aqueous solutions of glyceric acid calcium salt

Author(s): Bocková J, Jones NC, Leyva V, Gaysinski M, Hoffmann SV, Meinert C
Published in: Chirality, 2021, ISSN 0899-0042
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/chir.23407

Ionizing radiation exposure on Arrokoth shapes a sugar world

Author(s): Chaojiang Zhang, Vanessa Leyva, Jia Wang, Andrew M. Turner, Mason Mcanally, Ashanie Herath, Cornelia Meinert, Leslie A. Young, Ralf I. Kaiser
Published in: Proceedings of the National Academy of Sciences, Issue 121, 2024, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2320215121

Processing of Methane and Acetylene Ices by Galactic Cosmic Rays and Implications to the Color Diversity of Kuiper Belt Objects

Author(s): Chaojiang Zhang, Cheng Zhu, Andrew M. Turner, Ivan O. Antonov, Adrien D. Garcia, Cornelia Meinert, Leslie A. Young, David C. Jewitt, and Ralf I. Kaiser
Published in: Science Advances, Issue 9, 2023, Page(s) eadg6936, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adg6936

Fast and precise chiroptical spectroscopy by photoelectron elliptical dichroism

Author(s): Antoine Comby, Dominique Descamps, Stéphane Petit, Emmanuel Valzer, Morgan Wloch, Laurent Pouységu, Stéphane Quideau, Jana Bocková, Cornelia Meinert, Valérie Blanchet, Baptiste Fabre, Yann Mairesse
Published in: Physcial Chemistry Chemical Physics, Issue 25, 2023, Page(s) 16246-16263, ISSN 1463-9076
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3cp01057k

Uncovering the chiral bias of meteoritic isovaline through asymmetric photochemistry.

Author(s): Bocková J, Jones NC, Topin J, Hoffmann SV, Meinert C
Published in: Nature Communications, Issue 14, 2023, Page(s) 3381, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-39177-y

Chiroptical activity of gas-phase propylene oxide predicting the handedness of interstellar circular polarization in the presolar nebula

Author(s): Adrien D. Garcia; Jérémie Topin; Jana Bocková; Nykola C. Jones; Søren V. Hoffmann; Cornelia Meinert
Published in: Science Advances, Issue 8, 2022, ISSN 2375-2548
Publisher: American Association for the Advancement of Science's
DOI: 10.1126/sciadv.add4614

The astrochemical evolutionary traits of phospholipid membrane homochirality

Author(s): Jana Bocková, Nykola C. Jones, Søren V. Hoffmann, Cornelia Meinert
Published in: Nature Reviews Chemistry, Issue 8, 2024, Page(s) 652-664, ISSN 2397-3358
Publisher: Springer Nature
DOI: 10.1038/s41570-024-00627-w

The Astrophysical Formation of Asymmetric Molecules and the Emergence of a Chiral Bias

Author(s): Adrien Garcia, Cornelia Meinert, Haruna Sugahara, Nykola Jones, Søren Hoffmann, Uwe Meierhenrich
Published in: Life, Issue 9/1, 2019, Page(s) 29, ISSN 2075-1729
Publisher: MDPI
DOI: 10.3390/life9010029

Origin of alkylphosphonic acids in the interstellar medium

Author(s): Andrew M. Turner, Matthew J. Abplanalp, Alexandre Bergantini, Robert Frigge, Cheng Zhu, Bing-Jian Sun, Chun-Ta Hsiao, Agnes H. H. Chang, Cornelia Meinert, Ralf I. Kaiser
Published in: Science Advances, Issue 5/8, 2019, Page(s) eaaw4307, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.aaw4307

On the Production of Polyols and Hydroxycarboxylic Acids in Interstellar Analogous Ices of Methanol

Author(s): Cheng Zhu, Andrew M. Turner, Cornelia Meinert, Ralf I. Kaiser
Published in: The Astrophysical Journal, Issue 889/2, 2020, Page(s) 134, ISSN 1538-4357
Publisher: IOP Publishing
DOI: 10.3847/1538-4357/ab6326

L'asymétrie de la vie: une origine extraterrestre?

Author(s): Adrien Garcia, Jérémie Topin, Raphaël Pepino, Uwe J. Meierhenrich, Louis Le Sergeant D'Hendecourt, Cornelia Meinert
Published in: L'Actualité Chimique, Issue 446, 2019, Page(s) 34-40, ISSN 0151-9093
Publisher: Societe Francaise de Chimie

Resolution and quantification of carbohydrates by enantioselective comprehensive two-dimensional gas chromatography

Author(s): Adrien D Garcia, Vanessa Leyva, Jana Bocková, Raphaël L Pepino, Cornelia Meinert
Published in: Talanta, Issue 271, 2024, Page(s) 125728, ISSN 0039-9140
Publisher: Elsevier BV
DOI: 10.1016/j.talanta.2024.125728

Chiroptical activity of hydroxycarboxylic acids with implications for the origin of biological homochirality

Author(s): Jana Bocková, Nykola C. Jones, Uwe J. Meierhenrich, Søren V. Hoffmann, Cornelia Meinert
Published in: Communications Chemistry, Issue 4/1, 2021, ISSN 2399-3669
Publisher: Springer Nature
DOI: 10.1038/s42004-021-00524-z

Chiroptical properties of membrane glycerophospholipids and their chiral backbones

Author(s): Bocková J, Garcia AD, Jones NC, Hoffmann SV, Meinert C
Published in: Chirality, Issue 36, 2024, Page(s) e23654, ISSN 0899-0042
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/chir.23654

Olivine-catalyzed glycolaldehyde and sugar synthesis under aqueous conditions: Application to prebiotic chemistry

Author(s): Vassilissa Vinogradoff, Vanessa Leyva , Eric Mates-Torres, Raphael Pepino, Grégoire Danger, Albert Rimola, Lauryane Cazals, Coline Serra, Robert Pascal, Cornelia Meinert
Published in: Earth and Planetary Science Letters, Issue 626, 2024, ISSN 0012-821X
Publisher: Elsevier BV
DOI: 10.1016/j.epsl.2023.118558

Racemate Resolution of Alanine and Leucine on Homochiral Quartz, and Its Alteration by Strong Radiation Damage

Author(s): Adrien D. Garcia, Cornelia Meinert, Friedrich Finger, Uwe J. Meierhenrich, Ewald Hejl
Published in: Life, Issue 11/11, 2021, Page(s) 1222, ISSN 2075-1729
Publisher: MDPI
DOI: 10.3390/life11111222

Resolution, quantification, and reliable determination of enantiomeric excess of proteinogenic and non‐proteinogenic amino acids by comprehensive two‐dimensional gas chromatography

Author(s): Raphaël Pepino; Vanessa Leyva; Adrien D. Garcia; Jana Bocková; Cornelia Meinert
Published in: Journal of Separation Science, Issue volume 45, issue 24 (24/year), 2022, Page(s) 4416-4426, ISSN 1615-9306
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/jssc.202200606

Les innombrables applications de la chromatographie bidimensionnelle en phase gazeuse

Author(s): Pepino R, Garcia A, Bockova J, Garcia A, Danger G, Meierhenrich UJ, Meinert C
Published in: L’Actualité Chimique, Issue 459, 2021, Page(s) 20-26, ISSN 0151-9093
Publisher: Societe Francaise de Chimie

Abiotic formation of alkylsulfonic acids in interstellar analog ices and implications for their detection on Ryugu

Author(s): McAnally M, Bocková J, Ashanie Herath A, Turner AM, Meinert C*, Kaiser RI*
Published in: Nature Communications, Issue 15, 2024, Page(s) 4409, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-48684-5

Other (1)

Why are the molecules of life always left- or right-handed?

Author(s): Cornelia Meinert
Published in: Project Repository Journal, Issue 6, 2020, Page(s) 62-65, ISSN 2632-4067
Publisher: European Dissemination Media Agency

Thesis and dissertations (2)

The origins of homochirality : study by two-dimensional gas chromatography

Author(s): Garcia, Adrien
Published in: "Analytical chemistry. Université Côte d'Azur, 2021. English. ⟨NNT : 2021COAZ4087⟩", Issue 2, 2021
Publisher: Université Côte d'Azur

The origins of biomolecular asymmetry : study of extraterrestrial matter by two-dimensional gas chromatography

Author(s): Raphaël Pepino
Published in: 2022
Publisher: Université Côte d'Azur