Suppression of Organelle Defects in Human Disease

Project Information

SOLID

Grant agreement ID: 804182

DOI

10.3030/804182

Project closed

EC signature date 5 November 2018

Start date 1 July 2019

End date 30 April 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 498 400,00

EU contribution

€ 1 498 400,00

Coordinated by

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease

Author(s): Hannah K. Reinking, Hyun-Seo Kang, Maximilian J. Götz, Hao-Yi Li, Anja Kieser, Shubo Zhao, Aleida C. Acampora, Pedro Weickert, Evelyn Fessler, Lucas T. Jae, Michael Sattler, Julian Stingele
Published in: Molecular Cell, Issue 80/1, 2020, Page(s) 102-113.e6, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.08.003

DELE1 tracks perturbed protein import and processing in human mitochondria

Author(s): Evelyn Fessler, Luisa Krumwiede & Lucas T. Jae
Published in: Nature Communications, Issue 20411723, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-29479-y

The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A

Author(s): Imke K. Mandemaker, Evelyn Fessler, David Corujo, Christiane Kotthoff, Andreas Wegerer, Clément Rouillon, Marcus Buschbeck, Lucas T. Jae, Francesca Mattiroli, Andreas G. Ladurner
Published in: Cell Reports, Issue 42, 2024, Page(s) 113300, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.113300

Sensing, signaling and surviving mitochondrial stress

Author(s): Eva-Maria Eckl, Olga Ziegemann, Luisa Krumwiede, Evelyn Fessler, Lucas T. Jae
Published in: Cellular and Molecular Life Sciences, Issue 78/16, 2021, Page(s) 5925-5951, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-021-03887-7

A mitochondrial iron-responsive pathway regulated by DELE1

Author(s): Yusuke Sekine, Ryan Houston, Eva-Maria Eckl, Evelyn Fessler, Derek P. Narendra, Lucas T. Jae, Shiori Sekine
Published in: Molecular Cell, Issue 83, 2024, Page(s) 2059-2076.e6, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2023.05.031

Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation

Author(s): Che A. Stafford, Alicia-Marie Gassauer, Carina C. de Oliveira Mann, Maria C. Tanzer, Evelyn Fessler, Benedikt Wefers, Dennis Nagl, Gunnar Kuut, Karolina Sulek, Catherine Vasilopoulou, Sophia J. Schwojer, Andreas Wiest, Marie K. Pfautsch, Wolfgang Wurst, Monica Yabal, Thomas Fröhlich, Matthias Mann, Nicolas Gisch, Lucas T. Jae, Veit Hornung
Published in: Nature, Issue 609, 2022, Page(s) 590-596, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05125-x

OMA1 mediates local and global stress responses against protein misfolding in CHCHD10 mitochondrial myopathy

Author(s): Mario K. Shammas, Xiaoping Huang, Beverly P. Wu, Evelyn Fessler, Insung Y. Song, Nicholas P. Randolph, Yan Li, Christopher K.E. Bleck, Danielle A. Springer, Carl Fratter, Ines A. Barbosa, Andrew F. Powers, Pedro M. Quirós, Carlos Lopez-Otin, Lucas T. Jae, Joanna Poulton, and Derek P. Narendra
Published in: The Journal of Clinical Investigation, 2022, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci157504

A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol

Author(s): Evelyn Fessler, Eva-Maria Eckl, Sabine Schmitt, Igor Alves Mancilla, Matthias F. Meyer-Bender, Monika Hanf, Julia Philippou-Massier, Stefan Krebs, Hans Zischka, Lucas T. Jae
Published in: Nature, Issue 579/7799, 2020, Page(s) 433-437, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2076-4

Other (1)

AMPylation regulates PLD3 processing

Author(s): Laura Hoffmann, Eva-Maria Eckl, Marleen Bérouti, Michael Pries, Aron Koller, Charlotte Guhl, Ute A. Hellmich, Veit Hornung, Wei Xiang, Lucas T. Jae, Pavel Kielkowski
Published in: bioRxiv, 2025
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.01.09.632087

Non-peer reviewed articles (1)

Gestresste Mitochondrien: zwischen Zellschutz und Zelltod

Author(s): Hanna Fieler, Lucas T. Jae
Published in: BIOspektrum, Issue 30, 2025, Page(s) 502-504, ISSN 0947-0867
Publisher: Spektrum Akademischer Verlag GmbH
DOI: 10.1007/s12268-024-2254-2