Exploiting the hypoxia response in T cells for Next-Generation Immuno-Oncology

Project Information

NextGen IO

Grant agreement ID: 804236

DOI 10.3030/804236

Project closed

EC signature date 24 October 2018

Start date 1 February 2019

End date 31 January 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 993 575,00

EU contribution € 1 993 575,00

Coordinated by

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
Spain

Publications

Peer reviewed articles (14)

Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment

Author(s): Angela M. Araujo; Andrea Abaurrea; Peio Azcoaga; Joanna I. López-Velazco; Sara Manzano; Javier Rodriguez; Ricardo Rezola; Leire Egia-Mendikute; Fátima Valdés-Mora; Juana M. Flores; Liam Jenkins; Laura Pulido; Iñaki Osorio-Querejeta; Patricia Fernández-Nogueira; Nicola Ferrari; Cristina Viera; Natalia Martín-Martín; Alexandar Tzankov; Serenella Eppenberger-Castori; Isabel Alvarez-Lopez; Ande
Published in: The Journal of Clinical Investigation, 2022, Page(s) Apr 1;132(7):e148667, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci148667

An NMR-Based Model to Investigate the Metabolic Phenoreversion of COVID-19 Patients throughout a Longitudinal Study

Author(s): Rubén Gil-Redondo,Ricardo Conde, Ricardo Conde,Maider Bizkarguenaga,Chiara Bruzzone,Ana Laín,Beatriz González-Valle,Milagros Iriberri,Carlos Ramos-Acosta,Eduardo Anguita,Juan Ignacio Arriaga Lariz,Pedro Pablo España Yandiola,Miguel Ángel Moran,Mario Ernesto Jiménez-Mercado,Leire Egia-Mendikute,María Luisa Seco,Hartmut Schäfer,Claire Cannet,Manfred Spraul,Asís Palazón,Nieves Embade,Shelly
Published in: Metabolites, 2022, Page(s) 12(12), 1206, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo12121206

Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate

Author(s): Endika Prieto-Fernández, Leire Egia-Mendikute, Laura Vila-Vecilla, Alexandre Bosch, Adrián Barreira-Manrique, So Young Lee, Ana García-del Río, Asier Antoñana-Vildosola, Borja Jiménez-Lasheras, Leire Moreno-Cugnon, Jesús Jiménez-Barbero, Edurne Berra, June Ereño-Orbea, Asis Palazon
Published in: Emerging Microbes & Infections, Issue 10/1, 2021, Page(s) 1065-1076, ISSN 2222-1751
Publisher: Nature Publishing Group
DOI: 10.1080/22221751.2021.1932607

Sensitive detection of SARS-CoV-2 seroconversion by flow cytometry reveals the presence of nucleoprotein-reactive antibodies in unexposed individuals

Author(s): Leire Egia-Mendikute, Alexandre Bosch, Endika Prieto-Fernández, So Young Lee, Borja Jiménez-Lasheras, Ana García del Río, Asier Antoñana-Vildosola, Chiara Bruzzone, Maider Bizkarguenaga, Nieves Embade, Rubén Gil-Redondo, María Luz Martínez-Chantar, Marcos López-Hoyos, Nicola G. A. Abrescia, José M. Mato, Óscar Millet, Asís Palazón
Published in: Communications Biology, Issue 4/1, 2021, ISSN 2399-3642
Publisher: Nature publishing group
DOI: 10.1038/s42003-021-02011-6

A flow cytometry-based neutralization assay for simultaneous evaluation of blocking antibodies against SARS-CoV-2 variants

Author(s): Leire Egia-Mendikute; Alexandre Bosch; Endika Prieto-Fernández; Laura Vila-Vecilla; Samanta Romina Zanetti; So Young Lee; Borja Jiménez-Lasheras; Ana García del Río; Asier Antoñana-Vildosola; Ander de Blas; Paloma Velasco-Beltrán; Marina Serrano-Maciá; Paula Iruzubieta; Majid Mehrpouyan; Edward M. Goldberg; Scott J. Bornheimer; Nieves Embade; María L. Martínez-Chantar; Marcos López-Hoyos
Published in: Frontiers in immunology 13:1014309, 2022, Page(s) Nov 24;13:1014309, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2022.1014309

Hypoxia promotes syndecan-3 expression in the tumor microenvironment

Author(s): Endika Prieto-Fernández, Leire Egia-Mendikute, Alexandre Bosch, Ana García del Río, Borja Jimenez-Lasheras, Asier Antoñana-Vildosola, So Young Lee and Asis Palazon*
Published in: Frontiers in Immunology, 2020, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2020.586977

The outcome of boosting mitochondrial activity in alcohol-associated liver disease is organ-dependent

Author(s): Goikoetxea-Usandizaga, Naroa; Bravo, Miren; Egia-Mendikute, Leire; Abecia, Leticia; Serrano-Maciá, Marina; Urdinguio, Rocío G.; Clos-García, Marc; Rodríguez-Agudo, Rubén; Araujo-Legido, Raquel; López-Bermudo, Lucía; Delgado, Teresa C.; Lachiondo-Ortega, Sofía; González-Recio, Irene; Gil-Pitarch, Clàudia; Peña-Cearra, Ainize; Simón, Jorge; Benedé-Ubieto, Raquel; Ariño, Silvia; Herranz
Published in: Hepatology, Issue 1, 2023, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1097/hep.0000000000000303

Structural Characterization of N‐Linked Glycans in the Receptor Binding Domain of the SARS‐CoV‐2 Spike Protein and their Interactions with Human Lectins

Author(s): Maria Pia Lenza, Iker Oyenarte, Tammo Diercks, Jon Imanol Quintana, Ana Gimeno, Helena Coelho, Ana Diniz, Francesca Peccati, Sandra Delgado, Alexandre Bosch, Mikel Valle, Oscar Millet, Nicola G. A. Abrescia, Asís Palazón, Filipa Marcelo, Gonzalo Jiménez‐Osés, Jesús Jiménez‐Barbero, Ana Ardá, June Ereño‐Orbea
Published in: Angewandte Chemie International Edition, Issue 59/52, 2020, Page(s) 23763-23771, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202011015

The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes

Author(s): Maria Mercado-Gómez, Endika Prieto-Fernández, Naroa Goikoetxea-Usandizaga, Laura Vila-Vecilla, Mikel Azkargorta, Miren Bravo, Marina Serrano-Maciá, Leire Egia-Mendikute, Rubén Rodríguez-Agudo, Sofia Lachiondo-Ortega, So Young Lee, Alvaro Eguileor Giné, Clàudia Gil-Pitarch, Irene González-Recio, Jorge Simón, Petar Petrov, Ramiro Jover, Luis Alfonso Martínez-Cruz, June Ereño-Orbea, Teresa
Published in: Communications Biology, 2022, Page(s) 5, Article number: 827, ISSN 2399-3642
Publisher: Nature Research
DOI: 10.1038/s42003-022-03789-9

Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods

Author(s): Soledad Stagnoli; Francesca Peccati; Sean R. Connell; Ane Martinez-Castillo; Diego Charro; Oscar Millet; Chiara Bruzzone; Asis Palazon; Ana Ardá; Jesús Jiménez-Barbero; June Ereño-Orbea; Nicola G. A. Abrescia; Gonzalo Jiménez-Osés
Published in: Frontiers in Microbiology, Issue 7, 2022, Page(s) Apr 15;13:870938, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2022.870938

SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum

Author(s): Chiara Bruzzone, Maider Bizkarguenaga, Rubén Gil-Redondo, Tammo Diercks, Eunate Arana, Aitor García de Vicuña, Marisa Seco, Alexandre Bosch, Asís Palazón, Itxaso San Juan, Ana Laín, Jon Gil-Martínez, Ganeko Bernardo-Seisdedos, David Fernández-Ramos, Fernando Lopitz-Otsoa, Nieves Embade, Shelly Lu, José M. Mato, Oscar Millet
Published in: iScience, Issue 23/10, 2020, Page(s) 101645, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/j.isci.2020.101645

Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b.

Author(s): Maria Pia Lenza, Leire Egia-Mendikute, Asier Antoñana-Vildosola, Cátia O. Soares, Helena Coelho, Francisco Corzana, Alexandre Bosch, Prodhi Manisha, Jon Imanol Quintana, Iker Oyenarte, Luca Unione, María Jesús Moure, Mikel Azkargorta, Unai Atxabal, Klaudia Sobczak, Felix Elortza, James D. Sutherland, Rosa Barrio, Filipa Marcelo, Jesús Jiménez-Barbero, Asis Palazon & June Ereño-Orbea
Published in: Nature Communications, 2023, Page(s) 14, Article number: 3496 (2023), ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-39119-8

CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape

Author(s): Alba Rodriguez-Garcia, Asis Palazon, Estela Noguera-Ortega, Daniel J. Powell, Sonia Guedan
Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2020.01109

Neddylation tunes peripheral blood mononuclear cells immune response in COVID-19 patients.

Author(s): Marina Serrano-Maciá, Sofia Lachiondo-Ortega, Paula Iruzubieta, Naroa Goikoetxea-Usandizaga, Alexandre Bosch, Leire Egia-Mendikute, Borja Jiménez-Lasheras, Mikel Azkargorta, Félix Elortza, Diana Martinez-Redondo, Begoña Castro, Juan J Lozano, Ruben Nogueiras, Juan Irure-Ventura, Javier Crespo, Asís Palazón, María Carmen Fariñas, Teresa C Delgado, Marcos López-Hoyos, Maria L Martínez-Chan
Published in: Cell Death Discovery, 2022, Page(s) Jul 12;8(1):316, ISSN 2058-7716
Publisher: Springer Nature
DOI: 10.1038/s41420-022-01115-0