Elucidating the effects of ageing on the nucleoporin-directed neural cell type-specific nuclear architecture and gene regulation

Project Information

EAGER

Grant agreement ID: 804468

DOI 10.3030/804468

EC signature date 29 October 2018

Start date 1 March 2019

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 499 998,75

EU contribution € 1 499 998,75

Coordinated by

FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG
Germany

Publications

Peer reviewed articles (6)

A Nuclear Belt Fastens on Neural Cell Fate

Author(s): Ivan Mestres; Judith Houtman; Federico Calegari; Tomohisa Toda
Published in: Cells, Issue 20734409, 2022, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11111761

Lifelong persistence of nuclear RNAs in the mouse brain

Author(s): Sara Zocher, Asako McCloskey, Anne Karasinsky, Roberta Schulte, Ulrike Friedrich, Mathias Lesche, Nicole Rund, Fred H Gage, Martin W Hetzer, Tomohisa Toda
Published in: Science, 2024, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adf3481

Lamin B1 decline underlies age‐related loss of adult hippocampal neurogenesis

Author(s): Tracy A Bedrosian, Judith Houtman, Juan Sebastian Eguiguren, Saeed Ghassemzadeh, Nicole Rund, Nicole M Novaresi, Lauren Hu, Sarah L. Parylak, Ahmet M Denli, Lynne Randolph‐Moore, Takashi Namba, Fred H Gage, Tomohisa Toda
Published in: The EMBO Journal, Issue 40/3, 2021, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2020105819

Improved Method for Efficient Generation of Functional Neurons from Murine Neural Progenitor Cells

Author(s): Abhinav Soni, Diana Klütsch, Xin Hu, Judith Houtman, Nicole Rund, Asako McCloskey, Jerome Mertens, Simon T. Schafer, Hayder Amin, Tomohisa Toda
Published in: Cells, Issue 10/8, 2021, Page(s) 1894, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10081894

Epigenetic aging in adult neurogenesis

Author(s): Sara Zocher; Tomohisa Toda
Published in: "Hippocampus 33(4), 347-359 (2023). doi:10.1002/hipo.23494 special issue: ""Adult Neurogenesis in the Hippocampus""", Issue 1, 2023, ISSN 1050-9631
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hipo.23494

When function follows form: Nuclear compartment structure and the epigenetic landscape of the aging neuron

Author(s): Johannes C.M. Schlachetzki, Tomohisa Toda, Jerome Mertens
Published in: Experimental Gerontology, Issue 133, 2020, Page(s) 110876, ISSN 0531-5565
Publisher: Elsevier BV
DOI: 10.1016/j.exger.2020.110876