Elucidating the effects of ageing on the nucleoporin-directed neural cell type-specific nuclear architecture and gene regulation

Project Information

EAGER

Grant agreement ID: 804468

DOI

10.3030/804468

Project closed

EC signature date 29 October 2018

Start date 1 March 2019

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 998,75

EU contribution

€ 1 499 998,75

Coordinated by

FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG
Germany

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (7)

A Nuclear Belt Fastens on Neural Cell Fate

Author(s): Ivan Mestres; Judith Houtman; Federico Calegari; Tomohisa Toda
Published in: Cells, Issue 20734409, 2022, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11111761

Lifelong persistence of nuclear RNAs in the mouse brain

Author(s): Sara Zocher, Asako McCloskey, Anne Karasinsky, Roberta Schulte, Ulrike Friedrich, Mathias Lesche, Nicole Rund, Fred H Gage, Martin W Hetzer, Tomohisa Toda
Published in: Science, 2024, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adf3481

Dynamic expression of lamin <scp>B1</scp> during adult neurogenesis in the vertebrate brain

Author(s): Diana Zhilina, Lizbeth A. Bolaños Castro, Juan Sebastian Eguiguren, Sara Zocher, Anne Karasinsky, Dimitri Widmer, Alexandre Espinós, Victor Borrell, Michael Brand, Kyoko Miura, Oliver Zierau, Maximina H. Yun, Tomohisa Toda
Published in: Developmental Dynamics, 2025, ISSN 1058-8388
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/dvdy.70023

Lamin B1 decline underlies age‐related loss of adult hippocampal neurogenesis

Author(s): Tracy A Bedrosian, Judith Houtman, Juan Sebastian Eguiguren, Saeed Ghassemzadeh, Nicole Rund, Nicole M Novaresi, Lauren Hu, Sarah L. Parylak, Ahmet M Denli, Lynne Randolph‐Moore, Takashi Namba, Fred H Gage, Tomohisa Toda
Published in: The EMBO Journal, Issue 40/3, 2021, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2020105819

Improved Method for Efficient Generation of Functional Neurons from Murine Neural Progenitor Cells

Author(s): Abhinav Soni, Diana Klütsch, Xin Hu, Judith Houtman, Nicole Rund, Asako McCloskey, Jerome Mertens, Simon T. Schafer, Hayder Amin, Tomohisa Toda
Published in: Cells, Issue 10/8, 2021, Page(s) 1894, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10081894

Epigenetic aging in adult neurogenesis

Author(s): Sara Zocher; Tomohisa Toda
Published in: "Hippocampus 33(4), 347-359 (2023). doi:10.1002/hipo.23494 special issue: ""Adult Neurogenesis in the Hippocampus""", Issue 1, 2023, ISSN 1050-9631
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hipo.23494

When function follows form: Nuclear compartment structure and the epigenetic landscape of the aging neuron

Author(s): Johannes C.M. Schlachetzki, Tomohisa Toda, Jerome Mertens
Published in: Experimental Gerontology, Issue 133, 2020, Page(s) 110876, ISSN 0531-5565
Publisher: Elsevier BV
DOI: 10.1016/j.exger.2020.110876