Skip to main content

Elucidating the effects of ageing on the nucleoporin-directed neural cell type-specific nuclear architecture and gene regulation

Project description

Ageing and some of its pathologies may be related to a cellular identity crisis

A membrane-bound nucleus is what defines eukaryotic cells. To traffic macromolecules between the nucleus and the cytoplasm, the nuclear envelope has huge nuclear pore complexes (NPCs) consisting of more than 1 000 protein subunits in humans called nucleoporins. These NPCs are extremely long-lived and remain incorporated in the nuclear membrane for the entire life of the cell. Defects in nucleoporins play a role in cancer and ageing, and recently a link was found between nucleoporins, a key gene regulator and maintenance of cell identity in neural progenitor cells (that differentiate into neurons and glial cells). The EU-funded EAGER project is investigating the complicated relationship between cell type-specific gene regulation, cellular identity and ageing and disease.

Host institution

FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG
Net EU contribution
€ 80 356,44
Address
Schlossplatz 4
91054 Erlangen
Germany

See on map

Region
Bayern Mittelfranken Erlangen, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Beneficiaries (2)

FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG
Germany
Net EU contribution
€ 80 356,44
Address
Schlossplatz 4
91054 Erlangen

See on map

Region
Bayern Mittelfranken Erlangen, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV
Germany
Net EU contribution
€ 1 419 642,31
Address
Venusberg-campus 1/99
53127 Bonn

See on map

Region
Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt
Activity type
Research Organisations
Other funding
€ 0,00