Elucidating the effects of ageing on the nucleoporin-directed neural cell type-specific nuclear architecture and gene regulation

Project description

Ageing and some of its pathologies may be related to a cellular identity crisis

A membrane-bound nucleus is what defines eukaryotic cells. To traffic macromolecules between the nucleus and the cytoplasm, the nuclear envelope has huge nuclear pore complexes (NPCs) consisting of more than 1 000 protein subunits in humans called nucleoporins. These NPCs are extremely long-lived and remain incorporated in the nuclear membrane for the entire life of the cell. Defects in nucleoporins play a role in cancer and ageing, and recently a link was found between nucleoporins, a key gene regulator and maintenance of cell identity in neural progenitor cells (that differentiate into neurons and glial cells). The EU-funded EAGER project is investigating the complicated relationship between cell type-specific gene regulation, cellular identity and ageing and disease.

Programme(s)

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)

Topic(s)

• ERC-2018-STG - ERC Starting Grant

Call for proposal

ERC-2018-STG
See other projects for this call

Funding Scheme

ERC-STG - Starting Grant

Host institution

DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV

Address

Venusberg-campus 1/99
53127 Bonn
Germany

Activity type

Research Organisations

EU contribution

€ 1 499 998,75

Beneficiaries (1)

DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV

Germany

EU contribution

€ 1 499 998,75

Address

Venusberg-campus 1/99
53127 Bonn

Activity type

Research Organisations