Safeguarding Cell Fate by Terminal Repression during Development and Disease

Project Information

SafeFate

Grant agreement ID: 804710

DOI

10.3030/804710

Project closed

EC signature date 14 January 2019

Start date 1 February 2019

End date 31 January 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 761 489,00

EU contribution

€ 1 761 489,00

Coordinated by

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (5)

MYT1L haploinsufficiency in human neurons and mice causes autism-associated phenotypes that can be reversed by genetic and pharmacologic intervention

Author(s): Bettina Weigel, Jana F. Tegethoff, Sarah D. Grieder, Bryce Lim, Bhuvaneswari Nagarajan, Yu-Chao Liu, Jule Truberg, Dimitris Papageorgiou, Juan M. Adrian-Segarra, Laura K. Schmidt, Janina Kaspar, Eric Poisel, Elisa Heinzelmann, Manu Saraswat, Marleen Christ, Christian Arnold, Ignacio L. Ibarra, Joaquin Campos, Jeroen Krijgsveld, Hannah Monyer, Judith B. Zaugg, Claudio Acuna, Moritz Mall
Published in: Molecular Psychiatry, Issue 28, 2023, Page(s) 2122-2135, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-023-01959-7

Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis

Author(s): Bryce Lim, Aryan Kamal, Borja Gomez Ramos, Juan M. Adrian Segarra, Ignacio L. Ibarra, Lennart Dignas, Tim Kindinger, Kai Volz, Mohammad Rahbari, Nuh Rahbari, Eric Poisel, Kanela Kafetzopoulou, Lio Böse, Marco Breinig, Danijela Heide, Suchira Gallage, Jose E. Barragan Avila, Hendrik Wiethoff, Ivan Berest, Sarah Schnabellehner, Martin Schneider, Jonas Becker, Dominic Helm, Dirk Grimm, Taija Mäkine
Published in: Nature Genetics, Issue 57, 2025, Page(s) 668-679, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-025-02081-w

Canalizing cell fate by transcriptional repression

Author(s): Bryce Lim, Katrin Domsch, Moritz Mall, Ingrid Lohmann
Published in: Molecular Systems Biology, Issue 20, 2024, Page(s) 144-161, ISSN 1744-4292
Publisher: Nature Publishing Group
DOI: 10.1038/s44320-024-00014-z

Nuclear envelope rupture and NET formation is driven by PKCα-mediated lamin B disassembly

Author(s): Yubin Li; Minghui Li; Minghui Li; Bettina Weigel; Bettina Weigel; Moritz Mall; Moritz Mall; Victoria P. Werth; Ming-Lin Liu
Published in: EMBO reports, 2020, ISSN 1469-3178
Publisher: EMBO Press
DOI: 10.15252/embr.201948779

Pro-neuronal activity of Myod1 due to promiscuous binding to neuronal genes

Author(s): Qian Yi Lee, Moritz Mall, Soham Chanda, Bo Zhou, Kylesh S. Sharma, Katie Schaukowitch, Juan M. Adrian-Segarra, Sarah D. Grieder, Michael S. Kareta, Orly L. Wapinski, Cheen Euong Ang, Rui Li, Thomas C. Südhof, Howard Y. Chang, Marius Wernig
Published in: Nature Cell Biology, Issue 22/4, 2020, Page(s) 401-411, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-020-0490-3

Non-peer reviewed articles (1)

Safeguard repressor locks hepatocyte identity and blocks liver cancer

Author(s): Bryce Lim, Moritz Mall
Published in: Nature Genetics, Issue 57, 2025, Page(s) 494-495, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-025-02082-9

Book chapters (2)

Combining Cell Fate Reprogramming and Protein Engineering to Study Transcription Factor Functions

Author(s): Juan M. Adrian-Segarra, Bettina Weigel, Moritz Mall
Published in: Neural Reprogramming - Methods and Protocols, Issue 2352, 2021, Page(s) 227-236, ISBN 978-1-0716-1600-0
Publisher: Springer US
DOI: 10.1007/978-1-0716-1601-7_15

Isolation and Neuronal Reprogramming of Mouse Embryonic Fibroblasts

Author(s): Juan M. Adrian-Segarra, Bettina Weigel, Moritz Mall
Published in: Neural Reprogramming - Methods and Protocols, Issue 2352, 2021, Page(s) 1-12, ISBN 978-1-0716-1600-0
Publisher: Springer US
DOI: 10.1007/978-1-0716-1601-7_1

Other (3)

The glutamine-aspartate metabolic tradeoff between fast growth and metabolic flexibility

Author(s): Karin Ortmayr, Meret Ringwald, Laurentz Schuhknecht, Sébastien Dubuis, Eleni Paunossis, Martina Blaesi, Charly Jehanno, Sarah D. Grieder, Mohamed Bentires-Alj, Moritz Mall, Mattia Zampieri
Published in: bioRxiv, 2025
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.05.12.652188

Differential KEAP1/NRF2 mediated signaling widens the therapeutic window of redox-targeting drugs in SCLC therapy

Author(s): Jana Samarin, Hana Nuskova, Piotr Fabrowski, Mona Malz, Eberhard Amtmann, Minerva J. Taeubert, Daniel Pastor-Flores, Daniel Kazdal, Roman Kurilov, Nicole de Vries, Hannelore Pink, Franziska Deis, Johanna Hummel-Eisenbeiss, Kamini Kaushal, Tobias P. Dick, Gerhard Hamilton, Martina Muckenthaler, Moritz Mall, Bryce Lim, Taishi Kanamaru, Glynis Klinke, Martin Sos, Julia Frede, Aubry K. Miller, Hamed A
Published in: bioRxiv, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.11.06.621846

Decoding Plasticity Regulators and Transition Trajectories in Glioblastoma with Single-cell Multiomics

Author(s): Manu Saraswat, Laura Rueda-Gensini, Elisa Heinzelmann, Tannia Gracia, Fani Memi, Grant de Jong, Jannes Straub, Cedar Schloo, Dirk C. Hoffmann, Erik Jung, Tim Kindinger, Bettina Weigel, Bryce Lim, Sophie Weil, Oliver Gould, Richard Mair, Katharina Mikulik, Martin Rohbeck, Wolfgang Wick, Frank Winkler, Omer Ali Bayraktar, Oliver Stegle, Moritz Mall
Published in: bioRxiv, 2025
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.05.13.653733