Much of modern-day astrophysics is underpinned by the assumption that we have reliable models for stellar evolution in order to accurately ‘model’ stars. Unfortunately we have very little to prove this is the case. A well-known problem is that we rarely have a complete set of observations of any given star - from a small number of observations we must piece together the true picture. But, whatever observations we have, we do not have a direct measure of the initial stellar helium content. Initial He has a dramatic impact on inferred masses and ages of stars - e.g. an increase in initial He fraction of 0.05 for a Sun-like star will lead to a reduction of stellar MS lifetime of ~50%. Hence any quoted age is only valid for the adopted treatment of initial He and uncertainties quoted are a measure of precision not accuracy. This is not good enough for the many fields of astrophysics that rely on accurate stellar masses and ages.
In most real world cases progress has been made by tying initial He to initial metallicity but these relations are at best poorly calibrated, or at worst completely inappropriate. This systematic failure limits our understanding of our universe when we try to understand stars, the demographics of exoplanets, and the structure and evolution of our own Milky Way.