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Exploring the link between innate Immunity and cellular Aging


Interplay of cGAS with chromatin

Author(s): Marilena Wischnewski, Andrea Ablasser
Published in: Elsevier, 2021, ISSN 0968-0004
Publisher: Elsevier BV
DOI: 10.1016/j.tibs.2021.05.011

Structural mechanism of cGAS inhibition by the nucleosome

Author(s): Ganesh R. Pathare, Alexiane Decout, Selene Glück, Simone Cavadini, Kristina Makasheva, Ruud Hovius, Georg Kempf, Joscha Weiss, Zuzanna Kozicka, Baptiste Guey, Pauline Melenec, Beat Fierz, Nicolas H. Thomä, Andrea Ablasser
Published in: Nature, 2020, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2750-6

The cGAS–STING pathway as a therapeutic target in inflammatory diseases

Author(s): Decout, Alexiane; Katz, Jason D.; Venkatraman, Shankar; Ablasser, Andrea
Published in: Nature Reviews Immunology, 2021, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/s41577-021-00524-z

BAF restricts cGAS on nuclear DNA to prevent innate immune activation

Author(s): Baptiste Guey, Marilena Wischnewski, Alexiane Decout, Kristina Makasheva, Murat Kaynak, Mahmut S. Sakar, Beat Fierz, Andrea Ablasser
Published in: Science, 369/6505, 2020, Page(s) 823-828, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaw6421

The cGAS-STING pathway drives type I IFN immunopathology in COVID-19

Author(s): Di Domizio, J., Gulen, M.F., Saidoune, F. et al.
Published in: Nature, 2022, ISSN 1476-4687
Publisher: Springer Nature
DOI: 10.1038/s41586-022-04421-w