Exploring the link between innate Immunity and cellular Aging

Project Information

ImAgine

Grant agreement ID: 804933

DOI 10.3030/804933

Project closed

EC signature date 22 October 2018

Start date 1 January 2019

End date 31 December 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 489 520,00

EU contribution € 1 489 520,00

Coordinated by

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

Publications

Peer reviewed articles (7)

Interplay of cGAS with chromatin

Author(s): Marilena Wischnewski, Andrea Ablasser
Published in: Elsevier, 2021, ISSN 0968-0004
Publisher: Elsevier BV
DOI: 10.1016/j.tibs.2021.05.011

Structural mechanism of cGAS inhibition by the nucleosome

Author(s): Ganesh R. Pathare, Alexiane Decout, Selene Glück, Simone Cavadini, Kristina Makasheva, Ruud Hovius, Georg Kempf, Joscha Weiss, Zuzanna Kozicka, Baptiste Guey, Pauline Melenec, Beat Fierz, Nicolas H. Thomä, Andrea Ablasser
Published in: Nature, 2020, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2750-6

The cGAS–STING pathway as a therapeutic target in inflammatory diseases

Author(s): Decout, Alexiane; Katz, Jason D.; Venkatraman, Shankar; Ablasser, Andrea
Published in: Nature Reviews Immunology, 2021, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/s41577-021-00524-z

Clathrin-associated AP-1 controls termination of STING signalling

Author(s): Ying Liu, Pengbiao Xu, Sophie Rivara, Chong Liu, Jonathan Ricci, Xuefeng Ren, James H. Hurley, Andrea Ablasser.
Published in: Nature, 2022, ISSN 1476-4687
Publisher: Spring Nature Group
DOI: 10.1038/s41586-022-05354-0

BAF restricts cGAS on nuclear DNA to prevent innate immune activation

Author(s): Baptiste Guey, Marilena Wischnewski, Alexiane Decout, Kristina Makasheva, Murat Kaynak, Mahmut S. Sakar, Beat Fierz, Andrea Ablasser
Published in: Science, Issue 369/6505, 2020, Page(s) 823-828, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaw6421

cGAS–STING drives ageing-related inflammation and neurodegeneration

Author(s): Muhammet F. Gulen, Natasha Samson, Alexander Keller, Marius Schwabenland, Chong Liu, Sélène Glück, Vivek V. Thacker, Lucie Favre, Bastien Mangeat, Lona Kroese, Paul Krimpenfort, Marco Prinz, Andrea Ablasser.
Published in: Nature, 2023, ISSN 1476-4687
Publisher: Springer Nature Group
DOI: 10.1038/s41586-023-06373-1

The cGAS-STING pathway drives type I IFN immunopathology in COVID-19

Author(s): Di Domizio, J., Gulen, M.F., Saidoune, F. et al.
Published in: Nature, 2022, ISSN 1476-4687
Publisher: Springer Nature
DOI: 10.1038/s41586-022-04421-w