DNA: common culprit of ageing and immunity?
Inflammation is our immune system’s response to harmful stimuli such as pathogens or injury. One of the key mediators of inflammation is DNA, which triggers the cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway of innate immunity. The EU-funded ImAgine project is interested to understand the mechanisms by which cells detect and react to DNA, inducing inflammatory processes. Researchers aim to identify key players in the process and develop novel anti-inflammatory medicines. They are working under the hypothesis that inflammation constitutes one of the hallmarks of ageing and age-related disorders, which could be treated by targeting the inflammatory process.
Fields of science
Funding SchemeERC-STG - Starting Grant
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