Exploring the link between innate Immunity and cellular Aging

Project description

DNA: common culprit of ageing and immunity?

Inflammation is our immune system’s response to harmful stimuli such as pathogens or injury. One of the key mediators of inflammation is DNA, which triggers the cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway of innate immunity. The EU-funded ImAgine project is interested to understand the mechanisms by which cells detect and react to DNA, inducing inflammatory processes. Researchers aim to identify key players in the process and develop novel anti-inflammatory medicines. They are working under the hypothesis that inflammation constitutes one of the hallmarks of ageing and age-related disorders, which could be treated by targeting the inflammatory process.

Fields of science

• natural sciences › biological sciences › genetics › DNA
• medical and health sciences › health sciences › infectious diseases
• medical and health sciences › basic medicine › immunology

Programme(s)

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme

Topic(s)

• ERC-2018-STG - ERC Starting Grant

Call for proposal

ERC-2018-STG

See other projects for this call

Funding Scheme

ERC-STG - Starting Grant

Host institution

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

Net EU contribution

€ 1 489 520,00

Address

Batiment Ce 3316 Station 1
1015 Lausanne
Switzerland

Region

Schweiz/Suisse/Svizzera › Région lémanique › Vaud

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 1 489 520,00

Beneficiaries (1)

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

Switzerland

Net EU contribution

€ 1 489 520,00

Address

Batiment Ce 3316 Station 1
1015 Lausanne

Region

Schweiz/Suisse/Svizzera › Région lémanique › Vaud

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 1 489 520,00