Targeting pathological synaptic pruning by microglia in neurodegeneration

Project Information

REMIND

Grant agreement ID: 804949

DOI

10.3030/804949

Project closed

EC signature date 30 October 2018

Start date 1 January 2019

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 991,00

EU contribution

€ 1 499 991,00

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

To be completed

Publications

Peer reviewed articles (18)

Detection of Synaptic Proteins in Microglia by Flow Cytometry

Author(s): Simone Brioschi, Paolo d’Errico, Lukas S. Amann, Hana Janova, Sonja M. Wojcik, Melanie Meyer-Luehmann, Lawrence Rajendran, Peter Wieghofer, Rosa C. Paolicelli, Knut Biber
Published in: Frontiers in Molecular Neuroscience, Issue 13, 2020, ISSN 1662-5099
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnmol.2020.00149

Glial Contribution to Excitatory and Inhibitory Synapse Loss in Neurodegeneration

Author(s): Christopher M. Henstridge, Makis Tzioras, Rosa C. Paolicelli
Published in: Frontiers in Cellular Neuroscience, Issue 13, 2019, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2019.00063

Myeloid Metabolism as a New Target for Rejuvenation?-Comments on Restoring Metabolism of Myeloid Cells Reverses Cognitive Decline in Ageing. Nature. 2021 Feb;590(7844)122-128

Author(s): Marlen Knobloch, Rosa C. Paolicelli
Published in: Immunometabolism, Issue 3, 2024, ISSN 2633-0407
Publisher: Hapres
DOI: 10.20900/immunometab20210034

Cien Años de Microglía: Milestones in a Century of Microglial Research

Author(s): Amanda Sierra, Rosa C. Paolicelli, Helmut Kettenmann
Published in: Trends in Neurosciences, Issue 42/11, 2019, Page(s) 778-792, ISSN 0166-2236
Publisher: Elsevier BV
DOI: 10.1016/j.tins.2019.09.004

Microglia states and nomenclature: A field at its crossroads

Author(s): Rosa C. Paolicelli, Amanda Sierra, Beth Stevens, Marie-Eve Tremblay, Adriano Aguzzi, Bahareh Ajami, Ido Amit, Etienne Audinat, Ingo Bechmann, Mariko Bennett, Frederick Bennett, Alain Bessis, Knut Biber, Staci Bilbo, Mathew Blurton-Jones, Erik Boddeke, Dora Brites, Bert Brône, Guy C. Brown, Oleg Butovsky, Monica J. Carson, Bernardo Castellano, Marco Colonna, Sally A. Cowley, Colm Cunningham, Dimit
Published in: Neuron, Issue 110, 2024, Page(s) 3458-3483, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2022.10.020

Enzymatic Dissociation Induces Transcriptional and Proteotype Bias in Brain Cell Populations

Author(s): Daniele Mattei, Andranik Ivanov, Marc van Oostrum, Stanislav Pantelyushin, Juliet Richetto, Flavia Mueller, Michal Beffinger, Linda Schellhammer, Johannes vom Berg, Bernd Wollscheid, Dieter Beule, Rosa Chiara Paolicelli, Urs Meyer
Published in: International Journal of Molecular Sciences, Issue 21/21, 2020, Page(s) 7944, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21217944

Functional hypoxia reduces mitochondrial calcium uptake

Author(s): Chris Donnelly, Timea Komlódi, Cristiane Cecatto, Luiza H.D. Cardoso, Anne-Claire Compagnion, Alessandro Matera, Daniele Tavernari, Olivier Campiche, Rosa Chiara Paolicelli, Nadège Zanou, Bengt Kayser, Erich Gnaiger, Nicolas Place
Published in: Redox Biology, Issue 71, 2024, Page(s) 103037, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.1016/j.redox.2024.103037

Microglia in Health and Diseases: Integrative Hubs of the Central Nervous System (CNS)

Author(s): Amanda Sierra, Veronique E. Miron, Rosa C. Paolicelli, Richard M. Ransohoff
Published in: Cold Spring Harbor Perspectives in Biology, Issue 16, 2024, Page(s) a041366, ISSN 1943-0264
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a041366

Metabolic regulation of microglial phagocytosis: Implications for Alzheimer's disease therapeutics

Author(s): Izabela Lepiarz-Raba, Ismail Gbadamosi, Roberta Florea, Rosa Chiara Paolicelli, Ali Jawaid
Published in: Translational Neurodegeneration, Issue 12, 2023, ISSN 2047-9158
Publisher: BMC Springer Nature
DOI: 10.1186/s40035-023-00382-w

Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice

Author(s): Katia Monsorno, Kyllian Ginggen, Andranik Ivanov, An Buckinx, Arnaud L. Lalive, Anna Tchenio, Sam Benson, Marc Vendrell, Angelo D’Alessandro, Dieter Beule, Luc Pellerin, Manuel Mameli, Rosa Chiara Paolicelli
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-41502-4

Editorial: Assessing Microglial Function and Identity

Author(s): Amanda Sierra, Rosa Chiara Paolicelli
Published in: Frontiers in Immunology, Issue 12, 2021, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.824866

Discovery of a novel SHIP1 agonist that promotes degradation of lipid-laden phagocytic cargo by microglia

Author(s): Chiara Pedicone, Sandra Fernandes, Alessandro Matera, Shea T. Meyer, Stewart Loh, Jeung-Hoi Ha, Denzil Bernard, John D. Chisholm, Rosa Chiara Paolicelli, William G. Kerr
Published in: iScience, Issue 25, 2024, Page(s) 104170, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/j.isci.2022.104170

Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus

Author(s): Alessandro Matera, Anne-Claire Compagnion, Chiara Pedicone, Janssen M. Kotah, Andranik Ivanov, Katia Monsorno, Gwenaël Labouèbe, Loredana Leggio, Marta Pereira-Iglesias, Dieter Beule, Virginie Mansuy-Aubert, Tim L. Williams, Nunzio Iraci, Amanda Sierra, Samuele G. Marro, Alison M. Goate, Bart J.L. Eggen, William G. Kerr, Rosa C. Paolicelli
Published in: Immunity, Issue 58, 2025, Page(s) 197-217.e13, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2024.11.003

Microglial metabolic flexibility: emerging roles for lactate

Author(s): Katia Monsorno, An Buckinx, Rosa C. Paolicelli
Published in: Trends in Endocrinology & Metabolism, Issue 33, 2022, Page(s) 186-195, ISSN 1043-2760
Publisher: Elsevier BV
DOI: 10.1016/j.tem.2021.12.001

Plasticity of neuronal dynamics in the lateral habenula for cue-punishment associative learning

Author(s): Mauro Congiu, Sarah Mondoloni, Ioannis S. Zouridis, Lisa Schmors, Salvatore Lecca, Arnaud L. Lalive, Kyllian Ginggen, Fei Deng, Philipp Berens, Rosa Chiara Paolicelli, Yulong Li, Andrea Burgalossi, Manuel Mameli
Published in: Molecular Psychiatry, Issue 28, 2024, Page(s) 5118-5127, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-023-02155-3

Editorial: Cell-Cell Interactions Controlling Neuronal Functionality in Health and Disease

Author(s): Stefano Angiari, Giuseppina D'Alessandro, Rosa Chiara Paolicelli, Ilaria Prada, Eleonora Vannini
Published in: Frontiers in Integrative Neuroscience, Issue 16, 2022, ISSN 1662-5145
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnint.2022.968029

Clearance of β-amyloid and synapses by the optogenetic depolarization of microglia is complement selective

Author(s): Zezhong Lv, Lixi Chen, Ping Chen, Huipai Peng, Yi Rong, Wei Hong, Qiang Zhou, Nan Li, Boxing Li, Rosa C. Paolicelli, Yang Zhan
Published in: Neuron, Issue 112, 2025, Page(s) 740-754.e7, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2023.12.003

Cross-talk between GABAergic postsynapse and microglia regulate synapse loss after brain ischemia

Author(s): Teresa Cramer, Raminder Gill, Zahra S. Thirouin, Markus Vaas, Suchita Sampath, Fanny Martineau, Sara B. Noya, Patrizia Panzanelli, Tania J. J. Sudharshan, David Colameo, Philip K.-Y. Chang, Pei You Wu, Roy Shi, Philip A. Barker, Steven A. Brown, Rosa C. Paolicelli, Jan Klohs, Rebecca Anne McKinney, Shiva K. Tyagarajan
Published in: Science Advances, Issue 8, 2024, ISSN 2375-2548
Publisher: American Association for the Advancement of Science’s (AAAS)
DOI: 10.1126/sciadv.abj0112