Mechanical Immunoengineering for Enhanced T-cell Immunotherapy

Project Information

MechanoIMM

Grant agreement ID: 805337

DOI

10.3030/805337

Project closed

EC signature date 19 October 2018

Start date 1 December 2018

End date 30 November 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 800,00

EU contribution

€ 1 499 800,00

Coordinated by

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

Create and submit a Data Management Plan

Publications

Peer reviewed articles (13)

Delivery of STING Agonists for Adjuvanting Subunit Vaccines

Author(s): Van Herck, S.; Feng, Bing; Tang, L.
Published in: Advanced Drug Delivery Reviews, Issue 179, 2021, Page(s) 114020, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2021.114020

Smart chemistry for traceless release of anticancer therapeutics

Author(s): Prange, C.J.; Hu, X.; Tang, L.
Published in: Biomaterials, Issue 303, 2023, Page(s) 122353, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2023.122353

Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity

Author(s): Yugang Guo, Yu-Qing Xie, Min Gao, Yang Zhao, Fabien Franco, Mathias Wenes, Imran Siddiqui, Alessio Bevilacqua, Haiping Wang, Hanshuo Yang, Bing Feng, Xin Xie, Catherine M. Sabatel, Benjamin Tschumi, Amphun Chaiboonchoe, Yuxi Wang, Weimin Li, Weihua Xiao, Werner Held, Pedro Romero, Ping-Chih Ho, Li Tang
Published in: Nature Immunology, Issue 22/6, 2021, Page(s) 746-756, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-021-00940-2

Cytokine engineering for targeted cancer immunotherapy

Author(s): Lucia Bonati, Li Tang
Published in: Current Opinion in Chemical Biology, Issue 62, 2021, Page(s) 43-52, ISSN 1367-5931
Publisher: Elsevier BV
DOI: 10.1016/j.cbpa.2021.01.007

Cancer-Cell Stiffening via Cholesterol Depletion Enhances Adoptive T-cell Therapy

Author(s): Lei, K.; Kurum, A.; Kaynak, M.; Bonati, L.; Han, Y.; Cencen, V.; Gao, M.; Xie, Y.-Q.; Guo, Y.; Hannebelle, M.T.M.; Wu, Y.; Zhou, G; Guo, M.; Fantner, G.E.; Sakar, M.S.; Tang, L.
Published in: Nature Biomedical Engineering, Issue 5, 2021, Page(s) 1411-1425, ISSN 2157-846X
Publisher: Nature Research
DOI: 10.1038/s41551-021-00826-6

Mechanical Immunoengineering of T cells for Therapeutic Applications.

Author(s): Kewen Lei; Armand Kurum; Li Tang
Published in: Accounts of Chemical Research, Issue 1, 2021, ISSN 0001-4842
Publisher: American Chemical Society
DOI: 10.1021/acs.accounts.0c00486

A redox-responsive prodrug for tumor-targeted glutamine restriction

Author(s): Prange, C.J.; Ben Sayed, N.Y.; Feng, B.; Goepfert, C.; Trujillo, D.O.; Hu, X.; Tang, L.
Published in: Journal of Controlled Release, Issue 368, 2024, Page(s) 251-264, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2024.02.031

Soft Cancer Cells Squeeze Through T cell’s Grip

Author(s): Wang, Yi; Kurum, Armand; Tang, Li
Published in: Matter, Issue 5, 2022, Page(s) 2510-2513, ISSN 2590-2385
Publisher: Cell Press
DOI: 10.1016/j.matt.2022.06.041

BCG hydrogel promotes CTSS-mediated antigen processing and presentation, thereby suppressing metastasis and prolonging survival in melanoma.

Author(s): Kremenovic, Mirela; Chan, Alfred A; Feng, Bing; Bäriswyl, Lukas; Robatel, Steve; Gruber, Thomas; Tang, Li; Lee, Delphine J; Schenk, Mirjam
Published in: Journal for immunotherapy of cancer, Issue 10, 2022, Page(s) e004133, ISSN 2051-1426
Publisher: BMJ Publishing Group
DOI: 10.48350/170849

Switchable Immune Modulator for Tumor-Specific Activation of Anticancer Immunity

Author(s): Zhao, Y.; Xie, Y.-Q.; Van Herck, S.; Nassiri, S.; Gao, M.; Guo, Y.; Tang, L.
Published in: Sci. Adv., 2021, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abg7291

Rational design of chemically controlled antibodies and protein therapeutics

Author(s): Anthony Marchand; Lucia Bonati; Sailan Shui; Leo Scheller; Pablo Gainza; Stéphane Rosset; Sandrine Georgeon; Li Tang; Bruno E. Correia
Published in: ACS Chemical Biology, Issue 18, 2023, Page(s) 1259–1265, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1101/2022.12.22.521584

A Manganese Phosphate Nanocluster Activates the cGAS‐STING Pathway for Enhanced Cancer Immunotherapy

Author(s): Min Gao, Yu‐Qing Xie, Kewen Lei, Yu Zhao, Armand Kurum, Simon Van Herck, Yugang Guo, Xiaomeng Hu, Li Tang
Published in: Advanced Therapeutics, 2021, Page(s) 2100065, ISSN 2366-3987
Publisher: Wiley
DOI: 10.1002/adtp.202100065

T cell force-responsive delivery of anticancer drugs using mesoporous silica microparticles

Author(s): Kewen Lei, Li Tang
Published in: Materials Horizons, Issue 7/12, 2020, Page(s) 3196-3200, ISSN 2051-6347
Publisher: Cambridge, ROYAL SOC CHEMISTRY
DOI: 10.1039/d0mh01285h

Intellectual Property Rights

Patent (1)

IL-10/FC FUSION PROTEINS USEFUL AS ENHANCERS OF IMMUNOTHERAPIES

Application/Publication number: 20 20076089
Date: 2020-09-18
Applicant(s): ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE