Targeting genetic and epigenetic mechanisms in pediatric sarcomas.

Project Information

PedSarc

Grant agreement ID: 805338

DOI

10.3030/805338

Project closed

EC signature date 30 October 2018

Start date 1 January 2019

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 375,00

EU contribution

€ 1 499 375,00

Coordinated by

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Thesis and dissertations (2)

Epigenetic Deregulation by BCOR Oncogenic Fusions in Sarcomas

Author(s): Anastasija Pejkovska
Published in: Heidelberg University archives, 2025
Publisher: Heidelberg University

Distinct roles for Polycomb repressive complexes in synovial sarcoma

Author(s): Vineet Dalal
Published in: Heidelberg University archives, 2024
Publisher: Heidelberg University

Peer reviewed articles (4)

Preclinical In Vivo Modeling of Pediatric Sarcoma—Promises and Limitations

Author(s): Roland Imle, Felix K. F. Kommoss, Ana Banito
Published in: Journal of Clinical Medicine, Issue 10/8, 2021, Page(s) 1578, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10081578

Multi-omic and functional analysis for classification and treatment of sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions

Author(s): Julia Schöpf, Sebastian Uhrig, Christoph E. Heilig, Kwang-Seok Lee, Tatjana Walther, Alexander Carazzato, Anna Maria Dobberkau, Dieter Weichenhan, Christoph Plass, Mark Hartmann, Gaurav D. Diwan, Zunamys I. Carrero, Claudia R. Ball, Tobias Hohl, Thomas Kindler, Patricia Rudolph-Hähnel, Dominic Helm, Martin Schneider, Anna Nilsson, Ingrid Øra, Roland Imle, Ana Banito, Robert B. Russell, Barbara
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-44360-2

Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stability

Author(s): Nezha S. Benabdallah, Vineet Dalal, R. Wilder Scott, Fady Marcous, Afroditi Sotiriou, Felix K. F. Kommoss, Anastasija Pejkovska, Ludmila Gaspar, Lena Wagner, Francisco J. Sánchez-Rivera, Monica Ta, Shelby Thornton, Torsten O. Nielsen, T. Michael Underhill & Ana Banito
Published in: Nature Structural & Molecular Biology, 2023, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-023-01096-3

Somatic gene delivery faithfully recapitulates a molecular spectrum of high-risk sarcomas

Author(s): Roland Imle, Daniel Blösel, Felix K. F. Kommoss, Sara Placke, Eric Stutheit-Zhao, Christina Blume, Dmitry Lupar, Lukas Schmitt, Claudia Winter, Lena Wagner, Malte von Eicke, Hannah Walzer, Julia Förderer, Stephanie Laier, Michael Hertwig, Heike Peterziel, Ina Oehme, Sophia Scheuerman, Christian M. Seitz, Florian H. Geyer, Florencia Cidre-Aranaz, Thomas G. P. Grünewald, Christian Vokuhl, Priya C
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-60519-5

Non-peer reviewed articles (1)

Targeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in Synovial Sarcoma

Author(s): Konstantinos V. Floros, Carter K. Fairchild, Jinxiu Li, Kun Zhang, Jane L. Roberts, Richard Kurupi, Bin Hu, Vita Kraskauskiene, Nayyerehsadat Hosseini, Shanwei Shen, Melissa M. Inge, Kylie Smith-Fry, Li Li, Afroditi Sotiriou, Krista M. Dalton, Asha Jose, Elsamani I. Abdelfadiel, Yanli Xing, Ronald D. Hill, Jamie M. Slaughter, Mayuri Shende, Madelyn R Lorenz, Mandy R. Hinojosa, Benjamin R. Belvin,
Published in: Research Square, Issue 05 Jun, 2024, 2024, ISSN 2693-5015
Publisher: Springer Nature
DOI: 10.1101/2024.04.25.591023