Next Generation instrument for in-depth mitochondrial status analyses

Información del proyecto

NextGen-O2k

Identificador del acuerdo de subvención: 807889

DOI

10.3030/807889

Proyecto cerrado

Fecha de la firma de la CE 31 Enero 2018

Fecha de inicio 1 Febrero 2018

Fecha de finalización 31 Mayo 2018

Financiado con arreglo a

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies

Coste total

€ 71 429,00

Aportación de la UE

€ 50 000,00

Coordinado por

OROBOROS INSTRUMENTS GmbH
Austria

Periodic Reporting for period 1 - NextGen-O2k (Next Generation instrument for in-depth mitochondrial status analyses)

Período documentado: 2018-02-01 hasta 2018-05-31

Resumen del contexto y de los objetivos generales del proyecto

Mitochondria are important organelles that, besides of being the cellular energy source, are also involved in key metabolic and regulatory processes. Dysfunction in mitochondrial activity has a big impact in cellular physiology. In fact, recent discoveries have linked mitochondrial impairment with many pathological states, such as diabetes, cancer or neurological diseases. However, our understanding of the mitochondrial role in the development of these diseases is very limited, hindering therapeutic potential of mitochondria. The research instruments to study mitochondrial function are far from ideal and present several drawbacks: segmented information, low cost-effectiveness and sensitivity, poor resolution and introduction of systematic errors.
To solve this problem, Oroboros has designed a unique multi-sensor instrument to study mitochondrial function, the NextGen-O2k. We have used our core technology of High resolution FluoRespirometry to study oxygen flux, and added 4 new modules to study key aspects of mitochondrial bioenergetics. The NextGen-O2k gives a detailed snapshot of mitochondrial bioenergetics that can be used as a fingerprint of mitochondrial activity. It offers several advantages: “all in one” multi-parameter analysis, highest oxygen concentration resolution in the market, optimized cost-effectiveness and minimization of experimental errors.

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

We have performed a study to confirm viability of NextGen-O2k i) technically we designed final prototype and integration of hardware and software, ii) commercially we carried out a study of life science and mitochondrial research instruments, and iii) financially, we updated our business plan and confirmed project’s profitability.

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

NextGen-O2k aims to revolutionize the mitochondrial research field, helping scientists to unravel the molecular mechanisms of mitochondrial-associated diseases. On the long-term, we aim to develop a medical device based on NextGen-O2k for diagnosis and follow-up of several pathologies.

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