Principles of Integrin Mechanics and Adhesion

Project Information

PoInt

Grant agreement ID: 810104

DOI

10.3030/810104

EC signature date 15 January 2019

Start date 1 April 2019

End date 31 March 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 7 217 200,00

EU contribution

€ 7 217 200,00

Coordinated by

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (30)

Coexisting mechanisms of luminogenesis in pancreatic cancer-derived organoids

Author(s): Samuel J. Randriamanantsoa, Marion K. Raich, Dieter Saur, Maximilian Reichert, Andreas R. Bausch
Published in: iScience, Issue 27, 2025, Page(s) 110299, ISSN 2589-0042
Publisher: Elsevier BV
DOI: 10.1016/j.isci.2024.110299

Kindlin-3 loss curbs chronic myeloid leukemia in mice by mobilizing leukemic stem cells from protective bone marrow niches

Author(s): Peter William Krenn, Steffen Koschmieder, Reinhard Fässler
Published in: Proceedings of the National Academy of Sciences, Issue 117/39, 2020, Page(s) 24326-24335, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2009078117

KANK1 promotes breast cancer development by compromising Scribble-mediated Hippo activation

Author(s): Shiny Shengzhen Guo, Zhiying Liu, Guan M. Wang, Zhiqi Sun, Kaikai Yu, James P. Fawcett, Reinhard Buettner, Bo Gao, Reinhard Fässler
Published in: Nature Communications, Issue 15, 2024, Page(s) 10381, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-54645-9

In Vivo Photocontrol of Microtubule Dynamics and Integrity, Migration and Mitosis, by the Potent GFP-Imaging-Compatible Photoswitchable Reagents SBTubA4P and SBTub2M.

Author(s): Li Gao, Joyce C M Meiring, Adam Varady, Iris E Ruider, Constanze Heise, Maximilian Wranik , Cecilia D Velasco, Jennifer A Taylor, Beatrice Terni, Tobias Weinert, Jörg Standfuss, Clemens C Cabernard, Artur Llobet, Michel O Steinmetz, Andreas R Bausch, Martin Distel, Julia Thorn-Seshold, Anna Akhmanova, Oliver Thorn-Seshold
Published in: Journal of the American Chemical Society, Issue 144, 2022, Page(s) 5614-5628, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c01020

Mechanical plasticity of collagen directs branch elongation in human mammary gland organoids

Author(s): B. Buchmann, L. K. Engelbrecht, P. Fernandez, F. P. Hutterer, M. K. Raich, C. H. Scheel, A. R. Bausch
Published in: Nature Communications, Issue 12/1, 2021, Page(s) 2759, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-22988-2

Disruption of the integrin-linked kinase (ILK) pseudokinase domain affects kidney development in mice

Author(s): Nada Bulus, Kyle L. Brown, Glenda Mernaugh, Anika Böttcher, Xinyu Dong, Charles R. Sanders, Ambra Pozzi, Reinhard Fässler, Roy Zent
Published in: Journal of Biological Chemistry, Issue 296, 2021, Page(s) 100361, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100361

SlyD Accelerates trans-to-cis Prolyl Isomerization in a Mechanosignaling Protein under Load.

Author(s): Sengupta, A., L.E. Rognoni, U. Merkel, G. Zoldak and M. Rief.
Published in: Journal of Physical Chemistry B, Issue 125 (31), 2021, Page(s) 8712-8721, ISSN 1520-6106
Publisher: American Chemical Society
DOI: 10.1021/acs.jpcb.1c03648

Activity-induced polar patterns of filaments gliding on a sphere.

Author(s): Chiao-Peng Hsu, Alfredo Sciortino, Yu Alice de la Trobe, and Andreas R. Bausch.
Published in: Nature Communications, Issue 13, 2022, Page(s) 2579, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-30128-7

Correction: αv-Class integrin binding to fibronectin is solely mediated by RGD and unaffected by an RGE mutation

Author(s): María Benito-Jardón, Nico Strohmeyer, Sheila Otega-Sanchís, Mitasha Bharadwaj, Markus Moser, Daniel J. Müller, Reinhard Fässler, Mercedes Costell
Published in: Journal of Cell Biology, Issue 220/1, 2021, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.20200419812072020c

Cluster formation and phase separation driven by mobile myosin motors in the motility assay

Author(s): Brandon Slater, Alfredo Sciortino, Andreas R. Bausch, Taeyoon Kim
Published in: Physical Review Research, Issue 7, 2025, Page(s) 013312, ISSN 2643-1564
Publisher: American Physical Society (APS)
DOI: 10.1103/physrevresearch.7.013312

The role of nonlinear mechanical properties of biomimetic hydrogels for organoid growth.

Author(s): Benedikt Buchmann, Pablo Fernández, and Andreas R. Bausch
Published in: Biophysical Reviews, Issue 2/2, 2021, Page(s) 021401, ISSN 1867-2469
Publisher: Springer Nature
DOI: 10.1063/5.0044653

Self-organization in reconstituted actin networks by coupling monomer turnover and contractility.

Author(s): Bleicher P., Sciortino A., Bausch A.R.
Published in: Scientific Reports, Issue 10/1, 2020, Page(s) 6215, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-62942-8

The focal adhesion protein ß-parvin controls cardiomyocyte shape and sarcomere assembly in response to mechanical load

Author(s): Ingo Thievessen, Frank Suhr, Silvia Vergarajauregui, Ralph T. Böttcher, Klara Brixius, Georg Rosenberger, Oliver Dewald, Bernd K. Fleischmann, Alexander Ghanem, Marcus Krüger, Felix B. Engel, Ben Fabry, Wilhelm Bloch and Reinhard Fässler
Published in: Current Biology, Issue 32/14, 2022, Page(s) 3033-3047.e.9, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2022.05.047

In mitosis integrins reduce adhesion to extracellular matrix and strengthen adhesion to adjacent cells.

Author(s): Huber M, Casares-Arias J, Fässler R, Müller DJ, Strohmeyer N.
Published in: Nature Communications, Issue 14/1, 2023, Page(s) 2143, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-37760-x

Fibre-infused gel scaffolds guide cardiomyocyte alignment in 3D-printed ventricles.

Author(s): S. Choi, K. Y. Lee, S. L. Kim, L. A. MacQueen, H. Chang, J. F. Zimmerman, Q. Jin, M. M. Peters, H. A. M. Ardoña, A.-C. Heiler, X. Liu, C. Richardson, R. Gabardi, W. T. Pu, A. R. Bausch, and K. Kit Parker
Published in: Nature Materials, Issue 22/8, 2023, Page(s) 1039-1046, ISSN 1476-1122
Publisher: Nature Publishing Group
DOI: 10.1038/s41563-023-01611-3

Talin and kindlin use integrin tail allostery and direct binding to activate integrins

Author(s): Jonas Aretz, Masood Aziz, Nico Strohmeyer, Michael Sattler, Reinhard Fässler
Published in: Nature Structural & Molecular Biology, Issue 30, 2023, Page(s) 1913-1924, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-023-01139-9

Conformational Effects of a Cancer-Linked Mutation in Pri-miR-30c RNA.

Author(s): Jones, A. N., Walbrun, A., Falleroni, F., Rief, M. & Sattler.
Published in: Journal of Molecular Biology, Issue 434/18, 2022, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2022.167705

VASP localization to lipid bilayers induces polymerization driven actin bundle formation.

Author(s): Nast-Kolb, T., Bleicher, P., Payr, M. & Bausch, A. R.
Published in: Molecular Biology of the Cell, Issue 33/10, 2022, Page(s) ar91, ISSN 1939-4586
Publisher: American Society for Cell Biology
DOI: 10.1091/mbc.e21-11-0577

Intra-bundle contractions enable extensile properties of active actin networks

Author(s): P. Bleicher, T. Nast-Kolb, A. Sciortino, Y. A. de la Trobe, T. Pokrant, J. Faix, A. R. Bausch
Published in: Scientific Reports, Issue 11/1, 2021, Page(s) 2677, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-81601-0

The USP12/46 deubiquitinases protect integrins from ESCRT-mediated lysosomal degradation

Author(s): Kaikai Yu, Guan M Wang, Shiny Shengzhen Guo, Florian Bassermann, Reinhard Fässler
Published in: EMBO Reports, Issue 25, 2024, Page(s) 5687-5718, ISSN 1469-3178
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44319-024-00300-9

New insoights into the phosphorylation of the threonine motif of the β1 integrin cytoplasmic domain.

Author(s): Böttcher R.T., Strohmeyer N., Aretz J., and Fässler R.
Published in: Life Science Alliance, Issue 5(4), 2022, Page(s) e202101301, ISSN 2575-1077
Publisher: Life Science Alliance LLC
DOI: 10.26508/lsa.202101301

Polarity and chirality control of an active fluid by passive nematic defects.

Author(s): Sciortino, A., Neumann, L.J., Krüger, T., Maryshev I., Teshima T.F., Wolfrum B., Frey E., Bausch A.R.
Published in: Nature Materials, Issue 22/2, 2023, Page(s) 260-268, ISSN 1476-1122
Publisher: Nature Publishing Group
DOI: 10.1038/s41563-022-01432-w

Surface-tension-induced budding drives alveologenesis in human mammary gland organoids.

Author(s): Pablo A. Fernández, Benedikt Buchmann, Andriy Goychuk, Lisa K. Engelbrecht, Marion K. Raich, Christina H. Scheel, Erwin Frey and Andreas R. Bausch
Published in: Nature Physics, Issue 17, 2021, Page(s) 1130–1136, ISSN 1745-2481
Publisher: Nature Research
DOI: 10.1038/s41567-021-01336-7

Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids.

Author(s): S Randriamanantsoa, A Papargyriou , H C Maurer, K Peschke, M Schuster, G Zecchin, K Steiger, R Öllinger, D Saur, C Scheel, R Rad, E Hannezo, M Reichert , A R Bausch
Published in: Nature Communications, Issue 13/1, 2022, Page(s) 5219, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32806-y

Surface-induced phase separation of reconstituted nascent integrin clusters on lipid membranes.

Author(s): Hsu C.-P., Aretz J., Hordeichyk A., Fässler R., and Bausch A.R.
Published in: Proceedings of the Nacioanl Acadamy of Sciences, Issue 120/31, 2023, Page(s) e2301881120, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2301881120

Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins

Author(s): Shiny Shengzhen Guo, Andrea Seiwert, Irene Y.Y. Szeto, Reinhard Fässler
Published in: Experimental Cell Research, Issue 398/1, 2021, Page(s) 112391, ISSN 0014-4827
Publisher: Academic Press
DOI: 10.1016/j.yexcr.2020.112391

A molecular optomechanics approach reveals functional relevance of force transduction across talin and desmoplakin.

Author(s): Sadhanasatish T, Augustin K, Windgasse L, Chrostek-Grashoff A, Rief M, Grashoff C
Published in: Science Advances, Issue 9/25, 2023, Page(s) eadg3347, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adg3347

Kindlin stabilizes the talin·integrin bond under mechanical load by generating an ideal bond.

Author(s): Bodescu M.A., Aretz J., Grison M., Rief M., and Fässler R.
Published in: Proceedings of the National Acadamy of Sciences, Issue 120/26, 2023, Page(s) e:2218116120, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2218116120

αv-Class integrin binding to fibronectin is solely mediated by RGD and unaffected by an RGE mutation

Author(s): María Benito-Jardón, Nico Strohmeyer, Sheila Ortega-Sanchís, Mitasha Bharadwaj, Markus Moser, Daniel J. Müller, Reinhard Fässler, Mercedes Costell
Published in: Journal of Cell Biology, Issue 219/12, 2020, Page(s) e202004198, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202004198

CDK1–cyclin-B1-induced kindlin degradation drives focal adhesion disassembly at mitotic entry.

Author(s): Chen N.-P., Aretz J. Fässler R.
Published in: Nature Cell Biology, Issue 24, 2022, Page(s) 723–736, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-022-00886-z

Non-peer reviewed articles (1)

Collective Cell Migration During Human Mammary Gland Organoid Morphogenesis.

Author(s): F. P. Hutterer, B. Buchmann, L. Engelbrecht and A. R. Bausch
Published in: Biophysics Reviews, Issue 3, 2022, Page(s) 041401, ISSN 2688-4089
Publisher: AIP Publishing
DOI: 10.1063/5.0089767