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CORDIS - Resultados de investigaciones de la UE
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Principles of Integrin Mechanics and Adhesion

Publicaciones

Kindlin-3 loss curbs chronic myeloid leukemia in mice by mobilizing leukemic stem cells from protective bone marrow niches

Autores: Peter William Krenn, Steffen Koschmieder, Reinhard Fässler
Publicado en: Proceedings of the National Academy of Sciences, Edición 117/39, 2020, Página(s) 24326-24335, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2009078117

In Vivo Photocontrol of Microtubule Dynamics and Integrity, Migration and Mitosis, by the Potent GFP-Imaging-Compatible Photoswitchable Reagents SBTubA4P and SBTub2M.

Autores: Li Gao, Joyce C M Meiring, Adam Varady, Iris E Ruider, Constanze Heise, Maximilian Wranik , Cecilia D Velasco, Jennifer A Taylor, Beatrice Terni, Tobias Weinert, Jörg Standfuss, Clemens C Cabernard, Artur Llobet, Michel O Steinmetz, Andreas R Bausch, Martin Distel, Julia Thorn-Seshold, Anna Akhmanova, Oliver Thorn-Seshold
Publicado en: Journal of the American Chemical Society, Edición 144, 2022, Página(s) 5614-5628, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.2c01020

Mechanical plasticity of collagen directs branch elongation in human mammary gland organoids

Autores: B. Buchmann, L. K. Engelbrecht, P. Fernandez, F. P. Hutterer, M. K. Raich, C. H. Scheel, A. R. Bausch
Publicado en: Nature Communications, Edición 12/1, 2021, Página(s) 2759, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-22988-2

Disruption of the integrin-linked kinase (ILK) pseudokinase domain affects kidney development in mice

Autores: Nada Bulus, Kyle L. Brown, Glenda Mernaugh, Anika Böttcher, Xinyu Dong, Charles R. Sanders, Ambra Pozzi, Reinhard Fässler, Roy Zent
Publicado en: Journal of Biological Chemistry, Edición 296, 2021, Página(s) 100361, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100361

SlyD Accelerates trans-to-cis Prolyl Isomerization in a Mechanosignaling Protein under Load.

Autores: Sengupta, A., L.E. Rognoni, U. Merkel, G. Zoldak and M. Rief.
Publicado en: Journal of Physical Chemistry B, Edición 125 (31), 2021, Página(s) 8712-8721, ISSN 1520-6106
Editor: American Chemical Society
DOI: 10.1021/acs.jpcb.1c03648

Activity-induced polar patterns of filaments gliding on a sphere.

Autores: Chiao-Peng Hsu, Alfredo Sciortino, Yu Alice de la Trobe, and Andreas R. Bausch.
Publicado en: Nature Communications, Edición 13, 2022, Página(s) 2579, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-30128-7

Correction: αv-Class integrin binding to fibronectin is solely mediated by RGD and unaffected by an RGE mutation

Autores: María Benito-Jardón, Nico Strohmeyer, Sheila Otega-Sanchís, Mitasha Bharadwaj, Markus Moser, Daniel J. Müller, Reinhard Fässler, Mercedes Costell
Publicado en: Journal of Cell Biology, Edición 220/1, 2021, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.20200419812072020c

The role of nonlinear mechanical properties of biomimetic hydrogels for organoid growth.

Autores: Benedikt Buchmann, Pablo Fernández, and Andreas R. Bausch
Publicado en: Biophysical Reviews, Edición 2/2, 2021, Página(s) 021401, ISSN 1867-2469
Editor: Springer Nature
DOI: 10.1063/5.0044653

Self-organization in reconstituted actin networks by coupling monomer turnover and contractility.

Autores: Bleicher P., Sciortino A., Bausch A.R.
Publicado en: Scientific Reports, Edición 10/1, 2020, Página(s) 6215, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-62942-8

The focal adhesion protein ß-parvin controls cardiomyocyte shape and sarcomere assembly in response to mechanical load

Autores: Ingo Thievessen, Frank Suhr, Silvia Vergarajauregui, Ralph T. Böttcher, Klara Brixius, Georg Rosenberger, Oliver Dewald, Bernd K. Fleischmann, Alexander Ghanem, Marcus Krüger, Felix B. Engel, Ben Fabry, Wilhelm Bloch and Reinhard Fässler
Publicado en: Current Biology, Edición 32/14, 2022, Página(s) 3033-3047.e.9, ISSN 0960-9822
Editor: Cell Press
DOI: 10.1016/j.cub.2022.05.047

In mitosis integrins reduce adhesion to extracellular matrix and strengthen adhesion to adjacent cells.

Autores: Huber M, Casares-Arias J, Fässler R, Müller DJ, Strohmeyer N.
Publicado en: Nature Communications, Edición 14/1, 2023, Página(s) 2143, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-37760-x

Fibre-infused gel scaffolds guide cardiomyocyte alignment in 3D-printed ventricles.

Autores: S. Choi, K. Y. Lee, S. L. Kim, L. A. MacQueen, H. Chang, J. F. Zimmerman, Q. Jin, M. M. Peters, H. A. M. Ardoña, A.-C. Heiler, X. Liu, C. Richardson, R. Gabardi, W. T. Pu, A. R. Bausch, and K. Kit Parker
Publicado en: Nature Materials, Edición 22/8, 2023, Página(s) 1039-1046, ISSN 1476-1122
Editor: Nature Publishing Group
DOI: 10.1038/s41563-023-01611-3

Conformational Effects of a Cancer-Linked Mutation in Pri-miR-30c RNA.

Autores: Jones, A. N., Walbrun, A., Falleroni, F., Rief, M. & Sattler.
Publicado en: Journal of Molecular Biology, Edición 434/18, 2022, ISSN 0022-2836
Editor: Academic Press
DOI: 10.1016/j.jmb.2022.167705

VASP localization to lipid bilayers induces polymerization driven actin bundle formation.

Autores: Nast-Kolb, T., Bleicher, P., Payr, M. & Bausch, A. R.
Publicado en: Molecular Biology of the Cell, Edición 33/10, 2022, Página(s) ar91, ISSN 1939-4586
Editor: American Society for Cell Biology
DOI: 10.1091/mbc.e21-11-0577

Intra-bundle contractions enable extensile properties of active actin networks

Autores: P. Bleicher, T. Nast-Kolb, A. Sciortino, Y. A. de la Trobe, T. Pokrant, J. Faix, A. R. Bausch
Publicado en: Scientific Reports, Edición 11/1, 2021, Página(s) 2677, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-021-81601-0

New insoights into the phosphorylation of the threonine motif of the β1 integrin cytoplasmic domain.

Autores: Böttcher R.T., Strohmeyer N., Aretz J., and Fässler R.
Publicado en: Life Science Alliance, Edición 5(4), 2022, Página(s) e202101301, ISSN 2575-1077
Editor: Life Science Alliance LLC
DOI: 10.26508/lsa.202101301

Polarity and chirality control of an active fluid by passive nematic defects.

Autores: Sciortino, A., Neumann, L.J., Krüger, T., Maryshev I., Teshima T.F., Wolfrum B., Frey E., Bausch A.R.
Publicado en: Nature Materials, Edición 22/2, 2023, Página(s) 260-268, ISSN 1476-1122
Editor: Nature Publishing Group
DOI: 10.1038/s41563-022-01432-w

Surface-tension-induced budding drives alveologenesis in human mammary gland organoids.

Autores: Pablo A. Fernández, Benedikt Buchmann, Andriy Goychuk, Lisa K. Engelbrecht, Marion K. Raich, Christina H. Scheel, Erwin Frey and Andreas R. Bausch
Publicado en: Nature Physics, Edición 17, 2021, Página(s) 1130–1136, ISSN 1745-2481
Editor: Nature Research
DOI: 10.1038/s41567-021-01336-7

Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids.

Autores: S Randriamanantsoa, A Papargyriou , H C Maurer, K Peschke, M Schuster, G Zecchin, K Steiger, R Öllinger, D Saur, C Scheel, R Rad, E Hannezo, M Reichert , A R Bausch
Publicado en: Nature Communications, Edición 13/1, 2022, Página(s) 5219, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-32806-y

Surface-induced phase separation of reconstituted nascent integrin clusters on lipid membranes.

Autores: Hsu C.-P., Aretz J., Hordeichyk A., Fässler R., and Bausch A.R.
Publicado en: Proceedings of the Nacioanl Acadamy of Sciences, Edición 120/31, 2023, Página(s) e2301881120, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2301881120

Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins

Autores: Shiny Shengzhen Guo, Andrea Seiwert, Irene Y.Y. Szeto, Reinhard Fässler
Publicado en: Experimental Cell Research, Edición 398/1, 2021, Página(s) 112391, ISSN 0014-4827
Editor: Academic Press
DOI: 10.1016/j.yexcr.2020.112391

A molecular optomechanics approach reveals functional relevance of force transduction across talin and desmoplakin.

Autores: Sadhanasatish T, Augustin K, Windgasse L, Chrostek-Grashoff A, Rief M, Grashoff C
Publicado en: Science Advances, Edición 9/25, 2023, Página(s) eadg3347, ISSN 2375-2548
Editor: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adg3347

Kindlin stabilizes the talin·integrin bond under mechanical load by generating an ideal bond.

Autores: Bodescu M.A., Aretz J., Grison M., Rief M., and Fässler R.
Publicado en: Proceedings of the National Acadamy of Sciences, Edición 120/26, 2023, Página(s) e:2218116120, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2218116120

αv-Class integrin binding to fibronectin is solely mediated by RGD and unaffected by an RGE mutation

Autores: María Benito-Jardón, Nico Strohmeyer, Sheila Ortega-Sanchís, Mitasha Bharadwaj, Markus Moser, Daniel J. Müller, Reinhard Fässler, Mercedes Costell
Publicado en: Journal of Cell Biology, Edición 219/12, 2020, Página(s) e202004198, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.202004198

CDK1–cyclin-B1-induced kindlin degradation drives focal adhesion disassembly at mitotic entry.

Autores: Chen N.-P., Aretz J. Fässler R.
Publicado en: Nature Cell Biology, Edición 24, 2022, Página(s) 723–736, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-022-00886-z

Collective Cell Migration During Human Mammary Gland Organoid Morphogenesis.

Autores: F. P. Hutterer, B. Buchmann, L. Engelbrecht and A. R. Bausch
Publicado en: Biophysics Reviews, Edición 3, 2022, Página(s) 041401, ISSN 2688-4089
Editor: AIP Publishing
DOI: 10.1063/5.0089767

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