From Epigenetics of Cranial Neural Crest Plasticity to Intervertebral Disc Regeneration

Project Information

EpiCrest2Reg

Grant agreement ID: 810111

DOI

10.3030/810111

Project closed

EC signature date 5 February 2019

Start date 1 March 2019

End date 28 February 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 5 330 000,00

EU contribution

€ 5 330 000,00

Coordinated by

FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

Shaping faces: genetic and epigenetic control of craniofacial morphogenesis

Author(s): Selleri L, Rijli FM.
Published in: Nature Reviews Genetics, 2023, ISSN 1471-0056
Publisher: Nature Publishing Group
DOI: 10.1038/s41576-023-00594-w

Spheroid-Based Tissue Engineering Strategies for Regeneration of the Intervertebral Disc.

Author(s): Jesil Kasamkattil; Anna Gryadunova; Ivan Martin; Andrea Barbero; Stefan Schären; Olga Krupkova; Arne Mehrkens
Published in: International Journal of Molecular Sciences, Issue 25 Feb 2022, 23(5):2530, 2022, ISSN 2078-2489
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23052530

Polycomb chromatin topology enables long-range enhancer recruitment during craniofacial development

Author(s): Yousra Ben Zouari, Onkar Joshi, Adwait Salvi, Sandra Kessler, Sebastien Ducret, Fiona Ross, Sjoerd J. B. Holwerda, Nathalie Vilain, Soujanya Mamilla-Sanivaram, Sebastien Smallwood, Hubertus Kohler, Michael B. Stadler, Maryline Minoux, Filippo M. Rijli
Published in: Nature Communications, 2026, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-026-73065-5

A multiple super-enhancer region establishes inter-TAD interactions and controls Hoxa function in cranial neural crest

Author(s): Sandra Kessler, Maryline Minoux, Onkar Joshi, Yousra Ben Zouari, Sebastien Ducret, Fiona Ross, Nathalie Vilain, Adwait Salvi, Joachim Wolff, Hubertus Kohler, Michael B. Stadler, Filippo M. Rijli
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-38953-0

Different Ectopic Hoxa2 Expression Levels in Mouse Cranial Neural Crest Cells Result in Distinct Craniofacial Anomalies and Homeotic Phenotypes

Author(s): Kitazawa, T.; Minoux, M.; Ducret, S.; Rijli, F.M.
Published in: Journal of Developmental Biology (JDB), 2022, ISSN 2221-3759
Publisher: MDPI
DOI: 10.3390/jdb10010009

A mechanically active nucleus pulposus-on-a-chip for studying mechanobiology and therapeutic strategies in intervertebral disc disease

Author(s): Olga Krupkova, Bianca Aterini, Nader Rahal, Elias Schulze, Salim Darwiche, Martin Ehrbar, Karoliina Pelttari, Ivan Martin, Stefan Schären, Arne Mehrkens, Andrea Barbero, Andrea Mainardi
Published in: Biofabrication, Issue 18, 2026, Page(s) 015031, ISSN 1758-5082
Publisher: IOS Press
DOI: 10.1088/1758-5090/ae3d85

Human 3D nucleus pulposus microtissue model to evaluate the potential of pre-conditioned nasal chondrocytes for the repair of degenerated intervertebral disc

Author(s): Jesil Kasamkattil, Anna Gryadunova, Raphael Schmid, Max Hans Peter Gay-Dujak, Boris Dasen, Morgane Hilpert, Karoliina Pelttari, Ivan Martin, Stefan Schären, Andrea Barbero, Olga Krupkova, Arne Mehrkens
Published in: Frontiers in Bioengineering and Biotechnology, Issue 14 Feb 2023, 11:1119009, 2023, ISSN 2296-4185
Publisher: Frontiers Media
DOI: 10.3389/fbioe.2023.1119009

monaLisa: an R/Bioconductor package for identifying regulatory motifs

Author(s): Dania Machlab, Lukas Burger, Charlotte Soneson, Filippo M Rijli, Dirk Schübeler, Michael B Stadler
Published in: Bioinformatics, 2022, Page(s) 2624–2625, ISSN 1460-2059
Publisher: Oxford University Press
DOI: 10.1093/bioinformatics/btac102

Insights into chondrocyte populations in cartilaginous tissues at the single-cell level

Author(s): Csaba Matta, Roland Takács, Mona Dvir-Ginzberg, Stephen M. Richardson, Karoliina Pelttari, Girish Pattappa, Makarand V. Risbud, Ali Mobasheri
Published in: Nature Reviews Rheumatology, Issue 21, 2025, Page(s) 465-477, ISSN 1759-4790
Publisher: Nature Publishing Group
DOI: 10.1038/s41584-025-01275-0

Nose to Spine: spheroids generated by human nasal chondrocytes for scaffold-free nucleus pulposus augmentation.

Author(s): Anna Gryadunova; Jesil Kasamkattil; Max Hans Peter Gay; Boris Dasen; Karoliina Pelttari; Vladimir Mironov; Ivan Martin; Stefan Schären; Andrea Barbero; Olga Krupkova; Arne Mehrkens
Published in: Acta Biomaterialia, Issue 31 Jul 2021, 134, 2021, Page(s) 240-251, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2021.07.064

A unique bipartite Polycomb signature regulates stimulus-response transcription during development

Author(s): Taro Kitazawa, Dania Machlab, Onkar Joshi, Nicola Maiorano, Hubertus Kohler, Sebastien Ducret, Sandra Kessler, Henrik Gezelius, Charlotte Soneson, Panagiotis Papasaikas, Guillermina López-Bendito, Michael B. Stadler, Filippo M. Rijli
Published in: Nature Genetics, Issue 53/3, 2021, Page(s) 379-391, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-021-00789-z

An Ex Vivo Model of Intervertebral Disc Degeneration for Assessing Retention of Injectable Cell‐Based Grafts

Author(s): Raphael Schmid, Janhavi Apte, Elias Schulze, Andrej Sirek, Günther Schäfer, Jessica Schäper, Francesco Santini, Simona Negoias, Andrea Barbero, Ivan Martin, Karoliina Pelttari, Stefan Schären, Olga Krupkova, Arne Mehrkens
Published in: JOR SPINE, Issue 8, 2025, ISSN 2572-1143
Publisher: Wiley
DOI: 10.1002/jsp2.70144