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From Epigenetics of Cranial Neural Crest Plasticity to Intervertebral Disc Regeneration

Project description

Novel cell therapies for intervertebral disc regeneration

Lower back pain, primarily caused by intervertebral disc degeneration, is a leading disability cause. Cell therapy treatments present limited clinical efficacy because most cell sources do not regenerate the degenerated tissue. The EU-funded EpiCrest2Reg project proposes to employ nasal chondrocytes (NCs) because of their regenerative capacity and plasticity. However, a better understanding of the molecular mechanisms of NC plasticity is required to support their potential clinical use for intervertebral disc regeneration. Researchers will focus on the epigenetic chromatin signature of NCs and study the role of transcription and chromatin factors in NC plasticity. The knowledge gained, along with assessment of NCs in pre-clinical models, will be important towards a first-in-man application of NCs for treating intervertebral disc degeneration.

Host institution

FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
Net EU contribution
€ 2 670 000,00
Address
Maulbeerstrasse 66
4058 Basel
Switzerland

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Research Organisations
Other funding
€ 2 670 000,00

Beneficiaries (3)

FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
Switzerland
Net EU contribution
€ 2 670 000,00
Address
Maulbeerstrasse 66
4058 Basel

See on map

Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Research Organisations
Other funding
€ 2 670 000,00
UNIVERSITAT BASEL
Switzerland
Net EU contribution
€ 6 250,00
Address
Petersplatz 1
4051 Basel

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 6 250,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITATSSPITAL BASEL
Switzerland
Net EU contribution
€ 2 653 750,00
Address
Hebelstrasse 32
4031 Basel

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 2 653 750,00