Periodic Reporting for period 1 - IndiGene (Genetics of Individuality)
Reporting period: 2019-02-01 to 2020-07-31
This project makes use of the unique properties of medaka fish. Medaka can be fully inbred from the wild, are fertile and we have already sequenced of a panel of 111 inbred medaka lines originating from a single natural population. We will carry out in-depth profiling of these fish at multiple scales, ranging from molecular measurements to full organisms. We will analyse a number of traits in wild fish from the same source population, which will both increase our research potential and place our discoveries in the same context as human observational studies. A particular focus will be integrating this information across the cardiovascular systems, especially in comparison to human disease. We will host a “Research Hotel” that will provide and distribute the inbred medaka lines for other research projects that can be applied to this panel. This study will focus on the question of distinguishing between variation that occurs due to genetic, individual and environmental effects. This will lead to a more complete understanding of variation related to human disease and well-being.