Therapeutic immunotherapy targeting NG2 and CD22 antigens for MLL-rearranged and MLL-germline B-cell Acute Lymphoblastic Leukemia

Project Information

IT4B-ALL

Grant agreement ID: 811220

DOI 10.3030/811220

Project closed

EC signature date 17 September 2018

Start date 1 January 2019

End date 30 June 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 150 000,00

EU contribution € 150 000,00

Coordinated by

FUNDACIO INSTITUT DE RECERCA CONTRA LA LEUCEMIA JOSEP CARRERAS
Spain

Publications

Peer reviewed articles (8)

Efficient elimination of primary B-ALL cells in vitro and in vivo using a novel 4-1BB-based CAR targeting a membrane-distal CD22 epitope

Author(s): Talia Velasco-Hernandez, Samanta Romina Zanetti, Heleia Roca-Ho, Francisco Gutierrez-Aguera, Paolo Petazzi, Diego Sánchez-Martínez, Oscar Molina, Matteo Libero Baroni, Jose Luis Fuster, Paola Ballerini, Clara Bueno, Narcis Fernandez-Fuentes, Pablo Engel, Pablo Menendez
Published in: Journal for ImmunoTherapy of Cancer, Issue 8/2, 2020, Page(s) e000896, ISSN 2051-1426
Publisher: BML journals
DOI: 10.1136/jitc-2020-000896

NG2 antigen is a therapeutic target for MLL-rearranged B-cell acute lymphoblastic leukemia

Author(s): Belen Lopez-Millan, Diego Sanchéz-Martínez, Heleia Roca-Ho, Francisco Gutiérrez-Agüera, Oscar Molina, Rafael Diaz de la Guardia, Raúl Torres-Ruiz, Jose Luís Fuster, Paola Ballerini, Ute Suessbier, Cesar Nombela-Arrieta, Clara Bueno, Pablo Menéndez
Published in: Leukemia, Issue 33/7, 2019, Page(s) 1557-1569, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-018-0353-0

Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions

Author(s): Clara Bueno, Fernando J Calero-Nieto, Xiaonan Wang, Rafael Valdés-Mas, Francisco Gutiérrez-Agüera, Heleia Roca-Ho, Veronica Ayllon, Pedro J Real, David Arambilet, Lluis Espinosa, Raul Torres-Ruiz, Antonio Agraz-Doblas, Ignacio Varela, Jasper de Boer, Anna Bigas, Bertie Gottgens, Rolf Marschalek, Pablo Menendez
Published in: Haematologica, Issue 104/6, 2019, Page(s) 1189-1201, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.202044

Development of a Novel Anti-CD19 Chimeric Antigen Receptor: A Paradigm for an Affordable CAR T Cell Production at Academic Institutions

Author(s): Maria Castella, Anna Boronat, Raquel Martín-Ibáñez, Vanina Rodríguez, Guillermo Suñé, Miguel Caballero, Berta Marzal, Lorena Pérez-Amill, Beatriz Martín-Antonio, Julio Castaño, Clara Bueno, Olga Balagué, Europa Azucena González-Navarro, Carles Serra-Pages, Pablo Engel, Ramon Vilella, Daniel Benitez-Ribas, Valentín Ortiz-Maldonado, Joan Cid, Jaime Tabera, Josep M. Canals, Miquel Lozano,
Published in: Molecular Therapy - Methods & Clinical Development, Issue 12, 2019, Page(s) 134-144, ISSN 2329-0501
Publisher: Molecular Therapy:Methods and Clinical Development
DOI: 10.1016/j.omtm.2018.11.010

CD133-directed CAR T-cells for MLL leukemia: on-target, off-tumor myeloablative toxicity

Author(s): Clara Bueno, Talia Velasco-Hernandez, Francisco Gutiérrez-Agüera, Samanta Romina Zanetti, Matteo L. Baroni, Diego Sánchez-Martínez, Oscar Molina, Adria Closa, Antonio Agraz-Doblás, Pedro Marín, Eduardo Eyras, Ignacio Varela, Pablo Menéndez
Published in: Leukemia, Issue 33/8, 2019, Page(s) 2090-2125, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-019-0418-8

Natural history and cell of origin of TCF3-ZNF384 and PTPN11 mutations in monozygotic twins with concordant BCP-ALL

Author(s): Clara Bueno, J. Ramón Tejedor, Rachael Bashford-Rogers, Laura González-Silva, Rafael Valdés-Mas, Antonio Agraz-Doblás, Rafael Díaz de la Guardia, Jordi Ribera, Lurdes Zamora, Chrystele Bilhou-Nabera, Nassera Abermil, Hélène Guermouche, Elodie Gouache, Guy Leverger, Mario F. Fraga, Agustín F. Fernández, Paola Ballerini, Ignacio Varela, Pablo Menendez
Published in: Blood, Issue 134/11, 2019, Page(s) 900-905, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2019000893

Pro‐inflammatory cytokines favor the emergence of ETV6‐RUNX1‐positive pre‐leukemic cells in a model of mesenchymal niche

Author(s): Linda Beneforti, Erica Dander, Silvia Bresolin, Clara Bueno, Denise Acunzo, Mayla Bertagna, Anthony Ford, Bernhard Gentner, Geertruy te Kronnie, Patrizia Vergani, Pablo Menéndez, Andrea Biondi, Giovanna D’Amico, Chiara Palmi, Giovanni Cazzaniga
Published in: British Journal of Haematology, Issue 190/2, 2020, Page(s) 262-273, ISSN 0007-1048
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/bjh.16523

41BB-based and CD28-based CD123-redirected T-cells ablate human normal hematopoiesis in vivo

Author(s): Matteo Libero Baroni, Diego Sanchez Martinez, Francisco Gutierrez Aguera, Heleia Roca Ho, Maria Castella, Samanta Zanetti, Talia Velasco Hernandez, Rafael Diaz de la Guardia, Julio Castaño, Eduardo Anguita, Susana Vives, Josep Nomdedeu, Helene Lapillone, Anne E Bras, Vincent H J van der Velden, Jordi Junca, Pedro Marin, Alex Bataller, Jordi Esteve, Binje Vick, Irmela Jeremias, Angel Lopez, Marc S
Published in: Journal for ImmunoTherapy of Cancer, Issue 8/1, 2019, Page(s) e000845, ISSN 2051-1426
Publisher: BMJ Journals
DOI: 10.1136/jitc-2020-000845