Objective
Biomedical imaging has gained a significant technological push and is the mainstay for diag-nosis and therapy monitoring. Still, imaging is yet not optimized for the new class of biode-gradable Mg-based implants. MgSafe addresses this point by training 15 ESRs in both, imag-ing and implant technologies. All ESRs will develop their individual Personal Learning Envi-ronment (PLE) and be trained based on the “T-skills concept” in technologies and transferable skills relevant for their career development and prepared to take over leadership positions in an area of tremendous research promises and clinical relevance where the lack for experts is severe and very well recognized.
The ESRs will quantify the physical impact and suitability of a variety of modalities on Mg implants. Highly sophisticated imaging techniques (nano and µCT, MRT, PET, USPA, IR) will be developed beyond the forefront of medical device production in vivo and with in situ label-ling options to deliver non-invasively data on different time and length scales of the body reac-tion and material behavior during Mg degradation with a precision and plethora of details which is currently not available. Two Mg-alloys and CE-certified Mg-implants will be studied in rats and sheep. Dummy studies will be performed in parallel (following ASTM rules). The ob-tained multimodal imaging data will be combined with molecular biological/biochemical analy-sis, thereby increasing the information about physiological changes without using additional animals. An additional dimension will be added by the analysis of explants to obtain highest resolution chemical and material science data. All relevant biological and chemical in vivo and ex vivo data will be merged by computational 3D methods, simulations and machine learning approaches. The combination of these results will not only allow for an upscaling of the pro-cesses towards humans but will also deliver valuable data in terms of patient safety.
Fields of science
Programme(s)
Funding Scheme
MSCA-ITN-ETN - European Training NetworksCoordinator
21502 Geesthacht
Germany
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Participants (11)
00185 Roma
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8010 Graz
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0313 Oslo
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0167 Oslo
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30625 Hannover
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405 30 Goeteborg
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00-661 Warsaw
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13125 Berlin
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
30159 Hannover
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8306 Bruettisellen
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
1114 AB Amsterdam
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Partners (1)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
8010 Graz
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.