Promoting patient safety by a novel combination of imaging technologies for biodegradable magnesium implants

Deliverables

3.2 Characterisation of explant surface structure and com-position completed by ESR 9 and delivered to ESR 12

Characterisation of explant surface structure and composition completed by ESR 9 and data delivered to ESR 12

1.2 Comparison of 2D immunohistology, histomorphology & 3D bone structure delivered to ESRs 10-15

Comparison of 2D immunohistology & 3D bone structure delivered to ESRs 10-15

3.3 High-energy DPC-CT and scanning SAXS data analysis evaluated by ESR 10 and ESR 11 & delivered to ESR 12

Highenergy DPCCT and scanning SAXS data analysis evaluated by ESR 10 and ESR 11 delivered to ESR 12

4.3 3D data of photoacoustic imaging and data analysis de-livered to ESR 12

3D data of photoacoustic imaging and data analysis delivered to ESR 12

2.1 Stability & functionality of MRI/MRS on metallic im-plants demonstrated, instrument parameters delivered to ESRs 13-15.

Stability & functionality of MRI/MRS on metallic implants demonstrated, instrument parameters delivered to ESRs 13-15

1.3 Quantitative results of bone structure and composition, cellular and molecular activities during healing as well as data on tissue response and material degradation in both hard and soft tissues determined

Quantitative results of bone remodelling cellular and molecular activity during healing as well as degradation rate in both hard and soft tissues determined

2.3 Systemic immune reactions to Mg implants characterised

Systemic immune reactions to Mg implants characterised

2.4 Multimodal combination of quantitative cell activity & 3D bone structure delivered to ESRs 10-12 and WP4

Multimodal combination of quantitative cell activity 3D bone structure delivered to ESRs 1012 and WP4

8.11a MgSafe Brochure

MgSafe Brochure

8.11b MgSafe Movie

MgSafe Movie

8.5 MgSafe homepage is online

MgSafe homepage is online

8.11c Virtual Reality animations

Virtual Reality animations

7.2 A minimum of 4 network-wide leadership skills training events

A minimum of 4 network-wide leadership skills training events

5.2 A minimum of 8 network-wide scientific training events

A minimum of 8 network-wide scientific training events

6.2 A minimum of 5 network-wide transferable skills training events

A minimum of 5 network-wide transferable skills training events

Publications

Electrospinning for tissue engineering applications

Author(s): Maryam Rahmati, David K. Mills, Aleksandra M. Urbanska, Mohammad Reza Saeb, Jayarama Reddy Venugopal, Seeram Ramakrishna, Masoud Mozafari
Published in: Progress in Materials Science, Issue 117, 2021, Page(s) 100721, ISSN 0079-6425
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.pmatsci.2020.100721

Hard and soft tissue healing around implants with a modified implant neck configuration: An experimental in vivo preclinical investigation

Author(s): David Palombo, Maryam Rahmati, Fabio Vignoletti, Javier Sanz‐Esporrin, Håvard Jostein Haugen, Mariano Sanz
Published in: Clinical Oral Implants Research, Issue 32/9, 2021, Page(s) 1127-1141, ISSN 0905-7161
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/clr.13812

Early Osteoimmunomodulatory Effects of Magnesium–Calcium–Zinc alloys

Author(s): Maryam Rahmati, Sabine Stoetzel, Thaqif El Khassawna, Kamila Iskhakova, Florian Wieland, Berit Plumhoff Zeller , Håvard Jostein Haugen
Published in: Journal of Tissue Engineering, Issue 20417314, 2021, ISSN 2041-7314
Publisher: Journal of Tissue Engineering
DOI: 10.1177/20417314211047100

Scaling the U-net: segmentation of biodegradable bone implants in high-resolution synchrotron radiation microtomograms

Author(s): Ivo M. Baltruschat, Hanna Ćwieka, Diana Krüger, Berit Zeller-Plumhoff, Frank Schlünzen, Regine Willumeit-Römer, Julian Moosmann, Philipp Heuser
Published in: Scientific Reports, Issue 20452322, 2021, Page(s) 24237, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-03542-y

Degradation behavior and osseointegration of Mg-Zn-Ca screws in different bone regions of growing sheep—a pilot study

Author(s): R Marek, H Ćwieka, N Donohue, P Holweg, J Moosmann, F Beckmann, I Brcic, U Y Schwarze, K Iskhakova, M Chaabane, S Sefa, B Zeller-Plumhoff, A M Weinberg, R Willumeit-Römer, N G Sommer
Published in: Regenerative Biomaterials, Issue 20563418, 2022, ISSN 2056-3418
Publisher: Oxford University Press
DOI: 10.1093/rb/rbac077

Intrinsically disordered peptides enhance regenerative capacities of bone composite xenografts

Author(s): Rahmati, Maryam; Stoetzel, Sabine; El Khassawna, Thaqif; Mao, Chenyi; Ali, Adilijiang; Vaughan, Joshua C.; Iskhahova, Kamila; Wieland, D.C. Florian; Cantalapiedra, Antonio Gonzalez; Perale, Giuseppe; Betge, Felice; Dillon, Eoghan P; Lyngstadaas, Ståle Petter & Haugen, Håvard Jostein
Published in: Materials Today, 2021, ISSN 1369-7021
Publisher: Elsevier BV
DOI: 10.1016/j.mattod.2021.12.001

Immunohistochemical comparison of lateral bone augmentation using a synthetic TiO2 block or a xenogeneic graft in chronic alveolar defects

Author(s): Minh Khai Le Thieu , ,Sabine Stoetzel ,Maryam Rahmati ,Thaqif El Khassawna ,Anders Verket , ,Javier Sanz-Esporrin , ,Mariano Sanz MD, , ,Jan Eirik Ellingsen , ,Håvard Jostein Haugen
Published in: Clinical Implant Dentistry and Related Research, Issue 15230899, 2022, Page(s) 1-11, ISSN 1523-0899
Publisher: B.C. Decker Inc.
DOI: 10.1111/cid.13143

In Vitro Monitoring of Magnesium-Based Implants Degradation by Surface Analysis and Optical Spectroscopy

Author(s): Hafiz Wajahat Hassan, Maryam Rahmati, Alejandro Barrantes Håvard Jostein Haugen, and Peyman Mirtaheri
Published in: International Journal of Molecular Sciences, Issue 14220067, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23116099

An overview of assessment tools for determination of biological Magnesium implant degradation

Author(s): Hafiz Wajahat Hassan, Valeria Grasso, Olga Korostynska, Haroon Khan, Jithin Jose, Peyman Mirtaheri
Published in: Medical Engineering & Physics, Issue 93, 2021, Page(s) 49-58, ISSN 1350-4533
Publisher: Elsevier BV
DOI: 10.1016/j.medengphy.2021.05.016

Biological responses to physicochemical properties of biomaterial surface

Author(s): Maryam Rahmati, Eduardo A. Silva, Janne E. Reseland, Catherine A. Heyward, Håvard J. Haugen
Published in: Chemical Society Reviews, Issue 49/15, 2020, Page(s) 5178-5224, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cs00103a

Designing multigradient biomaterials for skin regeneration

Author(s): M. Rahmati, J.J. Blaker, S.P. Lyngstadaas, J.F. Mano, H.J. Haugen
Published in: Materials Today Advances, Issue 5, 2020, Page(s) 100051, ISSN 2590-0498
Publisher: © 2019 The Author(s). Published by Elsevier Ltd.
DOI: 10.1016/j.mtadv.2019.100051

An Automatic Unmixing Approach to Detect Tissue Chromophores from Multispectral Photoacoustic Imaging

Author(s): Valeria Grasso, Joost Holthof, Jithin Jose
Published in: Sensors, Issue 20/11, 2020, Page(s) 3235, ISSN 1424-8220
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s20113235

Recent advances in photoacoustic blind source spectral unmixing approaches and the enhanced detection of endogenous tissue chromophores

Author(s): Valeria Grasso, Hafiz Wajahat Hassan, Peyman Mirtaheri, Regine Willumeit-Rӧmer, Jithin Jose*
Published in: Frontiers in Signal Processing, 2022, ISSN 2673-8198
Publisher: Frontiers Media S.A
DOI: 10.3389/frsip.2022.984901

Coating doxycycline on titanium-based implants: Two in vivo studies

Author(s): Maryam Rahmati, Ståle Petter Lyngstadaas, Janne E. Reseland, Ingrid Andersbakken, Heidi Straume Haugland, Mónica López-Peña, Antonio Gonzalez Cantalapiedra, Fernando Maria Guzon Muñoz, Håvard Jostein Haugen
Published in: Bioactive Materials, Issue 5/4, 2020, Page(s) 787-797, ISSN 2452-199X
Publisher: KeAi Communications Co., Ltd.
DOI: 10.1016/j.bioactmat.2020.05.007

Osteoimmunomodulatory Effects of Enamel Matrix Derivate and Strontium Coating Layers: A Short- and Long-Term In Vivo Study

Author(s): Maryam Rahmati, Matthias Johannes Frank, Sebastian Martin Walter, Marta Cabrer Monjo, Maria Satué, Janne Elin Reseland, Ståle Petter Lyngstadaas, Håvard Jostein Haugen
Published in: ACS Applied Bio Materials, Issue 3/8, 2020, Page(s) 5169-5181, ISSN 2576-6422
Publisher: Copyright © 2020 American Chemical Society
DOI: 10.1021/acsabm.0c00608

Hard and soft tissue healing around teeth prepared with the biologically oriented preparation technique and restored with provisional crowns: An in vivo experimental investigation

Author(s): David Palombo, Maryam Rahmati, Fabio Vignoletti, Javier Sanz-Esporrin, Mari Paz Salido, Håvard Jostein Haugen, Mariano Sanz
Published in: Journal of Clinical Periodontology, 2023, ISSN 0303-6979
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jcpe.13825

Superpixel spectral unmixing framework for the volumetric assessment of tissue chromophores: A photoacoustic data-driven approach

Author(s): Valeria Grasso; Regine Willumeit-Rӧmer; Jithin Jose
Published in: Photoacoustics, Issue 22135979, 2022, ISSN 2213-5979
Publisher: Elsevier GmbH
DOI: 10.1016/j.pacs.2022.100367

The current performance of biodegradable magnesium-based implants in magnetic resonance imaging: A review

Author(s): Jonathan Espiritu, Martin Meier, Jan-Marten Seitz
Published in: Bioactive Materials, Issue 6/12, 2021, Page(s) 4360-4367, ISSN 2452-199X
Publisher: Elsevier B.V.
DOI: 10.1016/j.bioactmat.2021.04.012

Evaluating metallic artefact of biodegradable magnesium-based implants in magnetic resonance imaging

Author(s): Jonathan Espiritu, Mostafa Berangi, Christina Yiannakou, Eduarda Silva, Roberto Francischello, Andre Kuehne, Thoralf Niendorf, Sören Könneker, Regine Willumeit-Römer, Jan-Marten Seitz
Published in: Bioactive Materials, Issue 15, 2022, Page(s) 382-391, ISSN 2452-199X
Publisher: KeAi Publishing Communications Ltd.
DOI: 10.1016/j.bioactmat.2021.11.035

Solving the Time- and Frequency-Multiplexed Problem of Constrained Radiofrequency Induced Hyperthermia.

Author(s): Andre Kuehne; Eva Oberacker; Helmar Waiczies; Thoralf Niendorf
Published in: Cancers, Issue 20726694, 2020, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12051072

Unsupervised Multi-spectral Photoacoustic Framework for the Detection and Quantification of Tissue Chromophores

Author(s): Valeria Grasso, Regine Willumeit-Römer, Jithin Jose
Published in: IEEE International Ultrasonics Symposium (IUS), Issue 19485727, 2021, ISSN 1948-5727
Publisher: IEEE
DOI: 10.1109/ius52206.2021.9593631

Safe 7T MRI of tissues neighbouring Mg-based biodegradable implants using parallel transmission

Author(s): Mostafa Berangi, Andre Kuehne, and Thoralf Niendorf
Published in: Proceedings of the ISMRM 2021, 2021
Publisher: ISMRM

Feasibility study of multi-wavelength optical probe to analyze magnesium implant degradation effects

Author(s): Hafiz Wajahat Hassan; Anna Mathew; Haroon Khan; Olga Korostynska; Peyman Mirtaheri
Published in: IEEE Sensors, Issue 21689229, 2021, ISSN 2168-9229
Publisher: IEEE
DOI: 10.1109/sensors47087.2021.9639741

Parallel transmit local SAR vs. mesh resolution in EMF simulations of highly detailed anatomical models – a rigorous analysis

Author(s): A. Kuehne, E Oberacker, H Waiczies, M Berangi, J Nadobny, P Ghadjar, P Wust, T Niendorf
Published in: Proceedings of the Annual Meeting of the ISMRM 2020, 2020, ISSN 1545-4428
Publisher: ISMRM

Utilizing x-ray diffraction tomography to study the effect of biodegradable magnesium implants on the bone ultrastructure

Author(s): Kamila Iskhakova, D. C. Florian Wieland, Berit Zeller-Plumhoff, Regine Willumeit-Römer
Published in: Developments in X-Ray Tomography XIII, 2021, Page(s) 118400M
Publisher: SPIE
DOI: 10.1117/12.2593704

Excitation vector optimization for safe parallel transmission MRI of passively conducting implants in the presence of motion

Author(s): Mostafa Berangi, Andre Kuehne, Helmar Waiczies, and Thoralf Niendorf,
Published in: Annual Proceedings of the ISMRM 2022, 2022
Publisher: ISMRM

Deliverables

Publications

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