Description du projet
Un réseau de formation à la recherche sur les mécanismes d’endommagement de la peau sous l’effet des forces de cisaillement
Les propriétés mécaniques et biologiques de la peau humaine peuvent être affectées chez les personnes immobilisées sur un lit ou dans un fauteuil roulant, chez les amputés qui portent une prothèse, ou lorsque des dispositifs médicaux sont fixés sur la peau. Ces situations peuvent entraîner des escarres, notamment chez les personnes âgées et chez les diabétiques. En outre, la peau est sensible aux divers produits de soins personnels utilisés dans la vie quotidienne et responsables de diverses formes d’irritation. Financé par le programme Actions Marie Skłodowska-Curie, le projet STINTS va créer un réseau de chercheurs hautement spécialisés qui étudieront les événements biomécaniques et biochimiques responsables de la perte d’intégrité de la peau lors d’une exposition cutanée à des pressions et des forces de cisaillement prolongées. Son objectif est de minimiser les conséquences notables des affections cutanées débilitantes telles que les escarres sur les systèmes de santé et la qualité de vie des patients.
Objectif
The mechanical, chemical and biological properties of human skin may be challenged when in contact with another surface e.g. immobilized persons supported on a bed or in a wheelchair, amputees wearing a prosthesis, and individuals with orthoses or functional medical devices attached to the skin. This can result pressure ulcers, particularly in the elderly and those with comorbidities such as diabetes. Skin condition is also critical during interactions with personal care products such as creams, shavers, grooming devices, therapeutic lamps or massage equipment, which can result in various forms of irritation. The main scientific aim of STINTS is to understand the complex biomechanical and biochemical pathways leading to loss of skin integrity, following the exposure of the skin to prolonged pressure and shear forces that ultimately result in damage at the cellular level. The objective is to reduce the huge societal and financial costs of pressure ulcers by improving (a) the design of more effective preventative aids (mattresses, shoe insoles, incontinence products etc.), (b) early stage diagnosis (non-invasive biomarkers and sensors, and smart materials) and (c) ultrasound therapy. The new understanding of skin behaviour will also be exploited by application to personal care products (razors that cause minimal skin irritation and skin creams with more efficacious skin hydration and barrier properties). These objectives will be achieved by the deployment of experts in multi-scale computer simulation, experimental cellular and tissue biomechanics, biophysical monitoring, sensor design, medical devices and materials, and clinical studies. STINTS will create an ambitious environment of supradisciplinary inter-sectoral research training for early stage researchers that combines the needs for the creative skills of academic and industrial researchers, the entrepreneurial drive of the private sector and clinical innovation.
Champ scientifique
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health scienceshealth sciencesinfectious diseasesRNA virusesHIV
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensors
- medical and health sciencesmedical biotechnologyimplants
- natural sciencesmathematicsapplied mathematicsmathematical model
Mots‑clés
Programme(s)
Régime de financement
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinateur
B15 2TT Birmingham
Royaume-Uni