Description du projet
De nouveaux marqueurs biomécaniques pour un diagnostic précoce
La mécanique cellulaire est depuis longtemps liée à diverses maladies et affections. Financé par le programme Actions Marie Skłodowska-Curie, le projet Phys2BioMed entend identifier et appliquer des marqueurs biomécaniques pour la détection précoce du dysfonctionnement cellulaire et tissulaire dès le début de la maladie. Son objectif est de créer un réseau de formation interdisciplinaire pour les chercheurs en début de carrière sur l’application d’outils physiques au phénotypage mécanique des cellules et des tissus, afin de développer de nouveaux diagnostics précoces. Le réseau combinera des formations issues de divers domaines tels que les nanosciences et les nanotechnologies, la physique, la biologie et la médecine, définissant les principales caractéristiques d’une instrumentation de nouvelle génération optimisée pour le phénotypage mécanique des matériaux cliniques.
Objectif
Phys2BioMed will offer excellent interdisciplinary and cross-sectoral training to a team of motivated early stage researchers (ESRs) on the application of cutting-edge physical tools for the mechanical phenotyping of cells and tissues of clinical relevance, aiming at developing novel early-diagnostic tools. The Phys2BioMed network will merge diverse competences at European level, from different fields like nanoscience and nanotechnology, physics, biology, and medicine, and will expose ESRs to the non academic and private sector. A key element of the project is the peer-to-peer collaboration of research academic institutions with industries and world-leading medical and clinical centers; these are the main actors of the global challenge against diseases, and within Phys2BioMed they will highlight unmet clinical needs, and actively cooperate with academic colleagues for developing novel diagnostic strategies. ESRs will be trained-through-research by world-leading junior and senior PIs, and will benefit of lecture courses, dedicated international schools and workshops, and topical conferences. Secondments to other nodes of the network will represent the main and more effective channel of dissemination and cross-fertilization of competences, ideas, and knowledge within the network. Besides training talented young scientists, ready to work at the boundary of diverse disciplines in the field of nanomedicine, Phys2BioMed will provide scientific and technological outcomes on biomechanics, and the mechanical determinants of diseases. Technology-wise, it will define standardized procedures for nanomechanical measurements, and the definition of the main features of new-generation instrumentation optimized for the mechanical phenotyping of clinical specimens. In the longer-term, Phys2BioMed will provide the platform and know-how to build a data bank of mechanical fingerprints of diseases, setting the ground for the development of effective early-diagnostic tools.
Champ scientifique
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Régime de financement
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinateur
20122 Milano
Italie