Periodic Reporting for period 1 - ARCH (AGE-RELATED CHANGES IN HEMATOPOIESIS)
Reporting period: 2019-06-01 to 2021-05-31
Ageing is associated with an increased risk of acquiring various blood disorders, either malignant (myelodysplastic syndromes, myeloma, lymphomas) or non-malignant (such as anemias, primary immunodeficiency and coagulation disorders). Other blood disorders occur most often in children and are different from those seen in adults. The different incidence of different blood disorders at different ages suggests that they might reflect and undergo, in their onset and evolution, age-related changes in hematopoiesis, in a so far largely unknown manner. Many crucial questions remain unanswered. How does blood composition change as we age? Do these physiological changes have an impact on hematological diseases? The answer to these questions is the main focus of ARCH (Age-Related Changes in Hematopoiesis). By using integrate genetic, epigenetic, cellular and genomic approaches, ARCH studies the molecular mechanisms governing physiological changes of hematopoiesis throughout life and their correlation with pathological conditions, with the final goal to develop novel therapeutic strategies.
ARCH studies required the combination of transcriptomics, functional genomics, and the generation of cellular and in vivo models of premalignant/malignant cells to test novel therapeutic molecules/treatments. Through the development of these experimental approaches, ARCH students challenged themselves in the solving of complex scientific and technical problems. The parallel training in complementary skills organized by ARCH, dealing with the social and ethical implication of biomedical research, further enriched the ESRs scientific and personal growth.