AGE-RELATED CHANGES IN HEMATOPOIESIS

Project Information

ARCH

Grant agreement ID: 813091

DOI 10.3030/813091

Project closed

EC signature date 17 June 2019

Start date 1 June 2019

End date 30 November 2023

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 3 969 936,36

EU contribution € 3 969 936,36

Coordinated by

UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA
Italy

Deliverables

Documents, reports (4)

Online booklet on ARCH activity

Online booklet on ARCH activity

Documented yearly participation of ARCH partners and ESRs in local outreach events

Documented yearly participation of ARCH partners and ESRs in local Outreach Events

List of recruited fellows
News and Press Releases: ARCH launch and final report, scientific publications, patents, other achievements

News and Press Releases ARCH launch and final report scientific publications patents other achievements

Websites, patent fillings, videos etc. (2)

At minimum of four educational cartoons for lay public and high school students
At minimum of four microvideos and podcasts for broad audiences (general public, funding agencies, putative transfer targets);

Other (2)

List of participation in international external training events
Completion of Network Training Module events

Publications

Peer reviewed articles (19)

β-Hemoglobinopathies: The Test Bench for Genome Editing-Based Therapeutic Strategies

Author(s): Gloria Barbarani, Agata Łabedz, Antonella Ellena Ronchi
Published in: Frontiers in Genome Editing, Issue 2, 2020, ISSN 2673-3439
Publisher: Frontiers Media
DOI: 10.3389/fgeed.2020.571239

Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells

Author(s): Yu Wei Zhang, Julian Mess, Nadim Aizarani, Pankaj Mishra, Carys Johnson , Mari Carmen Romero-Mulero, Jasmin Rettkowski, Katharina Schönberger, Nadine Obier, Karin Jäcklein, Nadine M Woessner, Maria-Eleni Lalioti, Talia Velasco-Hernandez , Katarzyna Sikora, Ralph Wäsch, Bernhard Lehnertz, Guy Sauvageau, Thomas Manke, Pablo Menendez, Sebastian Gottfried Walter, Susana Minguet, Elisa Laurenti, Ste
Published in: Nature Cell Biology, 2022, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-022-00931-x

Definition and Prognostic Value of Ph-like and IKZF1plus Status in Children With Down Syndrome and B-cell Precursor Acute Lymphoblastic Leukemia

Author(s): Chiara Palmi, Silvia Bresolin, Stefanie Junk, Grazia Fazio, Daniela Silvestri, Marketa Zaliova, Athanasios Oikonomou, Katerina Scharov, Martin Stanulla, Anja Moericke, Martin Zimmermann, Martin Schrappe, Barbara Buldini, Sanil Bhatia, Arndt Borkhardt, Claudia Saitta, Marta Galbiati, Michela Bardini, Luca Lo Nigro, Valentino Conter, Maria Grazia Valsecchi, Andrea Biondi, Geertruy Te Kronnie, Gunnar
Published in: Hemasphere, 2023, ISSN 2572-9241
Publisher: Wolters Kluwer Health
DOI: 10.1097/hs9.0000000000000892

Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells.

Author(s): Giovanni Cova; Chiara Taroni; Marie-Céline Deau; Qi Cai; Vincent Mittelheisser; Muriel Philipps; Matthieu Jung; Marie Cerciat; Stephanie Gras; Christelle Thibault-Carpentier; Bernard Jost; Leif Carlsson; Angela M. Thornton; Ethan M. Shevach; Peggy Kirstetter; Philippe Kastner; Susan Chan
Published in: Journal of Experimental Medicine, Issue 2, 2021, ISSN 1540-9538
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20202317

A redox-based characterization of human immune cell subsets by polychromatic flow cytometry

Author(s): Christina Pitsillidou, Ivan Muradore, Elena Pontarini, Milena Bertolotti, Alessandra Roberto
Published in: Star Protocols, Issue Volume 4, Issue 4, 2023, ISSN 2666-1667
Publisher: Cell Press
DOI: 10.1016/j.xpro.2023.102632

A comprehensive transcriptome signature of murine hematopoietic stem cell aging

Author(s): Arthur Flohr Svendsen, Daozheng Yang, KyungMok Kim, Seka Lazare, Natalia Skinder, Erik Zwart, Anna Mura-Meszaros, Albertina Ausema, Björn von Eyss, Gerald de Haan, Leonid Bystrykh
Published in: Blood, 2021, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2020009729

JAK-STAT in Early Hematopoiesis and Leukemia

Author(s): Eirini Sofia Fasouli, Eleni Katsantoni
Published in: Frontiers in Cell and Developmental Biology, Issue 9, 2021, ISSN 2296-634X
Publisher: Frontiers Media
DOI: 10.3389/fcell.2021.669363

An instructive role for Interleukin-7 receptor α in the development of human B-cell precursor leukemia

Author(s): Ifat Geron; Angela Maria Savino; Hila Fishman; Noa Tal; John Brown; Virginia A. Turati; Chela James; Jolanda Sarno; Michal Hameiri-Grossman; Yu Nee Lee; Avigail Rein; Hillary Maniriho; Yehudit Birger; Anna Zemlyansky; Inna Muler; Kara L. Davis; Victoria Marcu-Malina; Nicole Mattson; Oren Parnas; Rabea Wagener; Ute Fischer; João T. Barata; Catriona H. M. Jamieson; Markus Müschen; Chun-Wei Chen; A
Published in: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022), Issue 1, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-28218-7

Role of Nuclear Receptors in Controlling Erythropoiesis

Author(s): Valentina Pastori, Serena Pozzi, Agata Labedz, Sajeela Ahmed, Antonella Ellena Ronchi
Published in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23052800

High-throughput screening as a drug repurposing strategy for poor outcome subgroups of pediatric B-cell precursor Acute Lymphoblastic Leukemia

Author(s): Athanasios Oikonomou, Luigia Valsecchi, Manuel Quadri, Titus Watrin, Katerina Scharov, Simona Procopio, Jia-Wey Tu, Melina Vogt, Angela Maria Savino, Daniela Silvestri, Maria Grazia Valsecchi, Andrea Biondi, Arndt Borkhardt, Sanil Bhatia, Giovanni Cazzaniga, Grazia Fazio, Michela Bardini, Chiara Palmi
Published in: Biochemical Pharmacology, 2023, ISSN 0006-2952
Publisher: Elsevier BV
DOI: 10.1016/j.bcp.2023.115809

Arrayed CRISPR/Cas9 Screening for the Functional Validation of Cancer Genetic Dependencies

Author(s): Ludovica Proietti, Gabriele Manhart, Elizabeth Heyes, Selina Troester, Florian Grebien
Published in: Bio Protocol, 2022, ISSN 2331-8325
Publisher: Bio Protocol
DOI: 10.21769/bioprotoc.4577

Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity

Author(s): Katharina Schoenberger, Nadine Obier, Mari Carmen Romero-Mulero, Pierre Cauchy, Julian Mess, Polina V. Pavlovich, Yu Wei Zhang, Michael Mitterer, Jasmin Rettkowski, Maria-Eleni Lalioti, Karin Jacklein, Jonathan D. Curtis, Betty Feret, Pia Sommerkamp, Claudia Morganti, Keisuke Ito, Norbert B. Ghyselinck, Eirini Trompouki, Joerg M. Buescher, Erika L. Pearce, and Nina Cabezas-Wallscheid
Published in: Cell Stem Cell, 2022, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2021.10.002

Multiple Roles of m6A RNA Modification in Translational Regulation in Cancer

Author(s): Guillermo Fernandez Rodriguez, Bianca Cesaro, Alessandro Fatica
Published in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23168971

CD61 identifies a superior population of aged murine HSCs and is required to preserve quiescence and self-renewal

Author(s): Natalia Skinder, Irene Sanz Fernández, Albertien Dethmers-Ausema, Ellen Weersing, Gerald de Haan
Published in: Blood Advances, 2023, ISSN 2473-9529
Publisher: American Society of Hematology
DOI: 10.1182/bloodadvances.2023011585

A journey into the unknown: PhD students in a european training network on age-related changes in hematopoiesis conduct their project during a global pandemic

Author(s): Pitsillidou, Christina; Alonso-Rubido, Sandra; Ávila-Ávila, Andrea; Romero-Mulero, Mari Carmen; Labedz, Agata; Oikonomou, Athanasios; Proietti, Ludovica; Psychoyiou, Maria Eleni; Tellez-Quijorna, Clara; Hillary, Manirio; Fasouli, Eirini Sofia; Fernández-Rodríguez, Guillermo; Giner-Laguarda, Natalia; Skinder, Natalia; Taroni, Chiara; Strouboulis, John; Katsantoni, Eleni; Ronchi, Antonella Ellen
Published in: HemaSphere, 2022, ISSN 2572-9241
Publisher: Wolters Kluwer Health, Inc. o
DOI: 10.1097/hs9.0000000000000763

GPRC5C Drives Branched-Chain Amino Acid Metabolism in Leukemogenesis

Author(s): Yu Wei Zhang, Talia Velasco-Hernandez, Julian Mess, Maria-Eleni Lalioti, Mari Carmen Romero-Mulero, Nadine Obier, Nikolaos Karantzelis, Jasmin Rettkowski, Katharina Schönberger, Noémie Karabacz, Karin Jäcklein, Tatsuya Morishima, Juan Luis Trincado, Paola Romecin, Alba Martinez-Moreno, Hitoshi Takizawa, Khalid Shoumariyeh, Simon Renders, Robert Zeiser, Heike L. Pahl, François Béliveau, Josée
Published in: Blood Advances, 2023, ISSN 2473-9537
Publisher: Elsevier
DOI: 10.1182/bloodadvances.2023010460

Functions of Polycomb Proteins on Active Targets

Author(s): Natalia Giner-Laguarda, Miguel Vidal
Published in: Epigenomes, Issue 4/3, 2020, Page(s) 17, ISSN 2075-4655
Publisher: MDPI
DOI: 10.3390/epigenomes4030017

Mouse multipotent progenitor 5 cells are located at the interphase between hematopoietic stem and progenitor cells

Author(s): Pia Sommerkamp, Mari Carmen Romero-Mulero, Andreas Narr*, Luisa Ladel*, Lucie Hustin, Katharina Schonberger, Simon Renders, Sandro Altamura, Petra Zeisberger, Karin Jacklein, Daniel Klimmeck, Alejo Rodriguez-Fraticelli, Fernando D. Camargo, Leïla Perie, Andreas Trumpp, and Nina Cabezas-Wallscheid.
Published in: Blood, 2021, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2020007876

Physiological and Aberrant γ-Globin Transcription During Development

Author(s): Gloria Barbarani, Agata Labedz, Sarah Stucchi, Alessia Abbiati, Antonella E. Ronchi
Published in: Frontiers in Cell and Developmental Biology, Issue 9, 2021, ISSN 2296-634X
Publisher: Frontiers Media
DOI: 10.3389/fcell.2021.640060