MicroTher: Drug Discovery from the Microbiota

Informations projet

MicroTher

N° de convention de subvention: 813099

DOI

10.3030/813099

Projet clôturé

Date de signature de la CE 10 Août 2018

Date de début 1 Septembre 2018

Date de fin 29 Février 2020

Financé au titre de

• EXCELLENT SCIENCE - European Research Council (ERC)

Coût total

€ 150 000,00

Contribution de l’UE

€ 150 000,00

Coordonné par

UNIVERSITA DEGLI STUDI DI PERUGIA
Italy

Periodic Reporting for period 1 - MicroTher (MicroTher: Drug Discovery from the Microbiota)

Période du rapport: 2018-09-01 au 2020-02-29

Résumé du contexte et des objectifs généraux du projet

The MicroTher project was designed with the objective to pave the way for the commercialization of a ‘postbiotic’ molecule, named Indole-3-aldehyde (3-IAld), able to repair the intestinal wall of animals. A preclinical pharmacological and toxicology study was a prerequisite to move 3-IAld towards commercialization for therapeutic purposes. The results confirmed the role of 3-IAld as a potential cure for broken guts without toxicity, and identified other molecules derived from 3-IAld that may contribute to its therapeutic effect. A market analysis to identify indications with the highest attractiveness for commercialization of 3-IAld prioritized the metabolic syndrome followed by Inflammatory Bowel Disease. The subsequent steps towards commercialization resulted in a collaborative research plan with a pharmaceutical company. Given the high burden of metabolic syndrome, the commercialization of 3-IAld, a safe, effective and economic molecule, may have a major socioeconomic impact.