Deliverables
Final network meeting combined with a biotech conference to promote the STACCATO (research) results.
Annual Network Training Events including 15 Modules5-day events consisting of the annual meeting and training modules specifically created for the STACCATO training. Modules are created to teach skills all ESRs will need and which will not me taught locally.
12 Webinars12 Webinars successfully completed
ESR Biotech PitchesEach ESR will develop a 5-minute STACCATO Biotech Pitch on their individual reseach topic. Pitches will be recorded and posted on the project website.
Single cell analysis for BioPharma SymposiumESRs organise a 1 day event to communicate the outputs of the STACCATO project to the BioPharma community.
STACCATO WikiA searchable online platform containing STACCATO relevant topics, made available through the website. It will contain basic information on related terminology and technologies as well as project results.
Optimisation of the production process for CAR T cells and understanding of the doseefficacy correlation
Effect of different protein product types on productivity and glycan heterogeneity in CHO cellsUnderstanding of the effect of different protein product types on productivity and glycan heterogeneity in CHO cells
Cell biology during extended HCDP cultureUnderstanding of the underlying cell biology during extended HCDP culture
Rhapsody scRNASeq, mtDNA and proteomics of cell therapiesRhapsody scRNASeq mtDNA and proteomics of cell therapies complete
Papers on STACCATO research results will be submitted to open access peerreviewed journals For nonopen access publications articles will be deposited in an online repository to be made accessible
STACCATO Podcast Seminar SeriesBiannual seminars to be broadcasted via FacebookLive Each seminar will be published via the STACCATO podcast on the project website
Conference presentations and postersParticipation of ESRs and PIs at relecant scientific conferences to disseminate the latest project results
STACCATO WebsiteThe project website of STACCATO will have the main purpose of illustrating the application of single cell analysis for bioprocess development to the general public Additionally it will be the main platform for disseminating resarch project results and informing about the project in general
Publications
Author(s):
Brian Ladd, Kevin Bowes, Mats Lundgren, Torbjörn Gräslund and Veronique Chotteau
Published in:
Processes, Issue 2022, 10(3), 515, 2022, ISSN 2227-9717
Publisher:
MDPI
DOI:
10.3390/pr10030515
Author(s):
Virgolini N., Silvano M., Hagan R., Correia R., Alves P., Clarke C., Roldao A., Isidro I.
Published in:
Biotechnology & Bioengineering, 2023, ISSN 1097-0290
Publisher:
Wiley Online Library
DOI:
10.22541/au.167121909.92795915/v1
Author(s):
Marco Silvano, Nikolaus Virgolini, Ricardo Correia, Colin Clarke, Ines A. Isidro, Paula M. Alves, Antonio Roldao
Published in:
Frontiers in Bioengineering and Biotechnology, Issue vol. 11, 2023, ISSN 2296-4185
Publisher:
Frontiers
DOI:
10.3389/fbioe.2023.1143255
Author(s):
Cervera-Carrascon V., Quixabeira DCA., Havunen R., Santos JM., Kutvonen E., Clubb JHA., Siurala M., Heiniö C., Zafar S., Koivula T., Lumen D., Vaha M., Garcia-Horsman A., Airaksinen AJ., Sorsa S., Anttila M., Hukkanen V., Kanerva A., Hemminki A.
Published in:
Molecular therapy oncolytics, Issue vol.17, 2020, ISSN 2372-7705
Publisher:
CellPress
DOI:
10.1016/j.omto.2020.03.003
Author(s):
Clubb J., Kudling T.V., Quixabeira D., Santos J., Havunen R., Heiniö C., Cervera-Carrascon V., Pakola S., Basnet S., Grönberg-Vähä-Koskela s., Kanerva A., & Hemminki A.
Published in:
Frontiers in Immunology, Issue vol.14, 2023, ISSN 1664-3224
Publisher:
Frontiers
DOI:
10.3389/fimmu.2023.1060540
Author(s):
Charitidis F.T., Adabi E., Thalheimer F.B., Clarke C., Buchholz C.J.
Published in:
Molecular Therapy – Methods & Clinical Development, Issue vol.23, 2022, ISSN 2329-0501
Publisher:
CellPress
DOI:
10.1016/j.omtm.2021.09.019
Author(s):
Ioanna Tzani, Craig Monger, Krishna Motheramgari, Clair Gallagher, Ryan Hagan, Paul Kelly, Alan Costello, Justine Meiller, Patrick Floris, Lin Zhang, Martin Clynes, Jonathan Bones, Niall Barron, Colin Clarke
Published in:
Biotechnology and Bioengineering, Issue 117/8, 2020, Page(s) 2489-2503, ISSN 0006-3592
Publisher:
Wiley - V C H Verlag GmbbH & Co.
DOI:
10.1002/bit.27365
Author(s):
Santos J, Heiniö C, Quixabeira D, Zafar S, Clubb J, Pakola S, Cervera-Carrascon V, Havunen R, Kanerva A, Hemminki A.
Published in:
Cells, Issue vol. 10 issue 5, 2022, ISSN 2073-4409
Publisher:
MDPI
DOI:
10.3390/cells10050978
Author(s):
Clubb J.H.A., Kudling T.V., Heiniö C., Basnet S., Pakola S., Cervera Carrascón V., Santos J.M., Quixabeira D.C.A., Havunen R., Sorsa S., Zheng V., Salo T., Bäck L., Aro K., Tulokas S., Loimu V., Hemminki A.
Published in:
Frontiers in Immunology, Issue vol. 13, 2022, ISSN 1664-3224
Publisher:
Frontiers
DOI:
10.3389/fimmu.2022.794251
Author(s):
Nikolaus Virgolini; Ryan Hagan; Ricardo Correia; Marco Silvano; Sofia Fernandes; Paula M. Alves; Colin Clarke; António Roldão; Inês A. Isidro
Published in:
Biotechnology Journal, 2022, ISSN 1860-7314
Publisher:
Wiley Online Library
DOI:
10.1002/biot.202200466
Author(s):
Louro A.F., Virgolini N., Paiva M.A., Isidro I.A., Alves P.M., Gomes-Alves P., Serra M.
Published in:
Frontiers in Physiology, Issue Vol 13, 2022, ISSN 1664-042X
Publisher:
Frontiers Research Foundation
DOI:
10.3389/fphys.2022.926528
Author(s):
Kudling T.V., Clubb J.H.A., Quixabeira D.C.A., Santos J.M., Havunen R., Kononov A., Heiniö C., Cervera-Carrascon V., Pakola S., Basnet S., Grönberg-Vähä-Koskela S., Arias V., Gladwyn-Ng I., Aro K., Bäck L., Räsänen J., Ilonen I., Borenius K., Räsänen M., Hemminki O., Rannikko A., Kanerva A., Tapper J., Hemminki A.
Published in:
OncoImmunology, Issue vol. 11, issue 1, 2022, ISSN 2162-4011
Publisher:
Landes Bioscience
DOI:
10.1080/2162402x.2022.2096572
Author(s):
Silvano, M., Correia, R., Virgolini, N., Clarke, C., Alves, P.M., Isidro, I.A., Roldão, A.
Published in:
Viruses, Issue vol- 14 issue 10, 2022, ISSN 1999-4915
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/v14102238
Author(s):
Ioanna Tzani, Nicolas Herrmann, Sara Carillo, Cathy A. Spargo, Ryan Hagan, Niall Barron, Jonathan Bones, W. Shannon Dillmore, Colin Clarke
Published in:
Biotechnology and Bioengineering, 2021, ISSN 0006-3592
Publisher:
Wiley - V C H Verlag GmbbH & Co.
DOI:
10.1002/bit.27715
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