Deliverables Other (1) Report on kick-off meeting Report on kick-off meeting Websites, patent fillings, videos etc. (1) Website I-DireCT public website Documents, reports (2) Update 2 online knowledge bases Update 2 online knowledge bases Update 1 online knowledge bases Update 1 online knowledge bases Publications Peer reviewed articles (20) DSP107 combines inhibition of CD47/SIRPα axis with activation of 4-1BB to trigger anticancer immunity Author(s): Ewa Cendrowicz; Lisa Jacob; Shirley Greenwald; Ami Tamir; Iris Pecker; Rinat Tabakman; Lucy Ghantous; Liat Tamir; Roy Kahn; Jasmine Avichzer; Alexandra Aronin; Shira Amsili; Elina Zorde-Khvalevsky; Yosi Gozlan; Martijn Vlaming; Gerwin Huls; Tom van Meerten; Michal Elhalel Dranitzki; Adam Foley-Comer; Yaron Pereg; Amnon Peled; Ayelet Chajut; Edwin Bremer Published in: VOLUME=41;ISSN=0392-9078;TITLE=Journal of experimental & clinical cancer research, Issue 5, 2022, ISSN 1756-9966 Publisher: BioMed Central Ltd DOI: 10.1186/s13046-022-02256-x CD20 positive CD8 T cells are a unique and transcriptionally-distinct subset of T cells with distinct transmigration properties Author(s): Martijn Vlaming, Vrouyr Bilemjian, Jimena Álvarez Freile, Harm Jan Lourens, Nienke van Rooij, Gerwin Huls, Tom van Meerten, Marco de Bruyn, Edwin Bremer Published in: Scientific Reports, 2021, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-021-00007-0 Receptor Oligomerization and Its Relevance for Signaling by Receptors of the Tumor Necrosis Factor Receptor Superfamily Author(s): Kirstin Kucka, Harald Wajant Published in: Frontiers in Cell and Developmental Biology, Issue 8, 2021, ISSN 2296-634X Publisher: Frontiers Media S.A. DOI: 10.3389/fcell.2020.615141 Whispering Gallery Modes-based biosensors for real-time monitoring and binding characterization of antibody-based cancer immunotherapeutics Author(s): Jimena Álvarez Freile; Ghizlane Choukrani; Kerstin Zimmermann; Edwin Bremer; Lars Dähne Published in: Sensors and actuators b-Chemical, 346:130512. Elsevier Science, Issue 4, 2021, ISSN 0925-4005 Publisher: Elsevier BV DOI: 10.1016/j.snb.2021.130512 Development of vaterite particles for therapeutic protein drug delivery and pH-sensitive release mimicking the tumor microenvironment. Author(s): Ghizlane Choukrani, Jimena Álvarez Freile, Wei Wan, Gabriella Egri, Natasha Ustyanovska Avtenyuk (ESR2, UMCG/SURF), Valerie Wiersma, Edwin Bremer, Lars Dähne Published in: Particle, 2021, ISSN 2571-712X Publisher: MDPI AG DOI: 10.1002/ppsc.202100012 Towards Immunotherapy-Induced Normalization of the Tumor Microenvironment Author(s): Vinicio Melo, Edwin Bremer, John D. Martin Published in: Frontiers in immunology, 2022, ISSN 1664-3224 Publisher: Frontiers Media S.A. DOI: 10.3389/fcell.2022.908389 CD24 is a potential immunotherapeutic target for Mantle Cell Lymphoma Author(s): Jimena Álvarez Freile, Natasha Ustyanovska Avtenyuk, Macarena González Corrales, Harm Jan Lourens, Gerwin Huls, Tom van Meerten, Ewa Cendrowicz, and Edwin Bremer Published in: Biomedicines, 2022, ISSN 2227-9059 Publisher: MDPI DOI: 10.3390/biomedicines10051175 Membrane lymphotoxin-α2β is a novel tumor necrosis factor (TNF) receptor 2 (TNFR2) agonist Author(s): Kucka, Kirstin; Lang, Isabell; Zhang, Tengyu; Siegmund, Daniela; Medler, Juliane; Wajant, Harald Published in: Cell Death and Disease, Vol 12, Iss 4, Pp 1-9 (2021), Issue 6, 2021, ISSN 2041-4889 Publisher: Nature Publishing Group DOI: 10.1038/s41419-021-03633-8 The Novel Immune Checkpoint GPR56 Is Expressed on Tumor-Infiltrating Lymphocytes and Selectively Upregulated upon TCR Signaling Author(s): Vrouyr Bilemjian; Martijn R. Vlaming; Jimena Álvarez Freile; Gerwin Huls; Marco De Bruyn; Edwin Bremer Published in: Cancer (Basel), Issue 9, 2023, ISSN 2072-6694 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers14133164 CD40- and 41BB-specific antibody fusion proteins with PDL1 blockade-restricted agonism Author(s): Juliane Medler, Kirstin Kucka, Vinicio Melo, Tengyu Zhang, Stefan von Rotenhan, Jakob Ulrich, Edwin Bremer, Michael Hudecek, Andreas Beilhack, and Harald Wajant Published in: Theranostics, 2022, ISSN 1838-7640 Publisher: Ivyspring International Publisher DOI: 10.7150/thno.66119 Anti-Fn14 Antibody-Conjugated Nanoparticles Display Membrane TWEAK-Like Agonism. Author(s): Ahmed Aido; Olena Zaitseva; Harald Wajant; Matej Buzgo; Aiva Simaite Published in: Pharmaceutics, Issue 6, 2021, ISSN 1999-4923 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/pharmaceutics13071072 Galectin-9 has non-apoptotic cytotoxic activity towards Acute Myeloid Leukemia independent of cytarabine resistance. Author(s): Ghizlane Choukrani, Nienke Visser, Natasha Ustyanovska Avtenyuk, Mirjam Olthuis, Glenn Marsman, Emanuele Ammatuna, Harm Jan Lourens, Toshiro Niki, Gerwin Huls, Edwin Bremer and Valerie R. Wiersma. Published in: Cell Death Discovery, 2023, ISSN 2058-7716 Publisher: Nature Publishing Group DOI: 10.1038/s41420-023-01515-w Facing the Challenges of Pharmaceutical Research Using Whispering Gallery Modes-Based Biosensors Author(s): Lars Dähne Published in: American Journal of Biomedical Science & Research, Issue 8/2, 2020, Page(s) 161-162, ISSN 2642-1747 Publisher: Biomedgrid DOI: 10.34297/ajbsr.2020.08.001259 Galectin-9 Triggers Neutrophil-Mediated Anticancer Immunity Author(s): Natasha Ustyanovska Avtenyuk; Ghizlane Choukrani; Emanuele Ammatuna; Toshiro Niki; Ewa Cendrowicz; Harm Jan Lourens; Gerwin Huls; Valerie R. Wiersma; Edwin Bremer Published in: Biomedicines, Vol 10, Iss 66, p 66 (2022), Issue 4, 2021, ISSN 2227-9059 Publisher: MDPI DOI: 10.3390/biomedicines10010066 Antibody-based soluble and membrane-bound TWEAK mimicking agonists with FcγR-independent activity. Author(s): Zaitseva O, Hoffmann A, Löst M, Anany MA, Zhang T, Kucka K, Wiegering A, Otto C, Wajant H. Published in: Frontiers in immunology, 2023, ISSN 1664-3224 Publisher: Frontiers Media S.A. DOI: 10.3389/fimmu.2023.1194610 The Neutrophil: The Underdog That Packs a Punch in the Fight against Cancer Author(s): Natasha Ustyanovska Avtenyuk, Nienke Visser, Edwin Bremer, Valerie R. Wiersma Published in: International Journal of Molecular Sciences, Issue 21/21, 2020, Page(s) 7820, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms21217820 Tumor infiltrating CD8/CD103/TIM-3-expressing lymphocytes in epithelial ovarian cancer co-express CXCL13 and associate with improved survival Author(s): Martijn Vlaming, Vrouyr Bilemjian, Jimena Álvarez Freile, Vinicio Melo, Annechien Plat, Gerwin Huls, Hans W. Nijman, Marco de Bruyn, Edwin Bremer Published in: Front. Immunol., 2022, ISSN 1664-3224 Publisher: Frontiers Media S.A DOI: 10.3389/fimmu.2022.1031746 Using Nanomedicine to Drive Advances in Cancer Immunotherapy: A Mini Review. Author(s): Choukrani G, Freile JA, Bremer E, Daehne L Published in: American Journal of Biomedical Science & Research, 2020, ISSN 2642-1747 Publisher: Biomedgrid DOI: 10.34297/ajbsr.2020.08.001248 EGFR-selective activation of CD27 co-stimulatory signaling by a bispecific antibody enhances anti-tumor activity of T cells Author(s): Vinicio Melo, Levi Collin Nelemans, Martijn Vlaming, Harm Jan Lourens, Valerie R. Wiersma, Vrouyr Bilemjian, Gerwin Huls, Marco de Bruyn, and Edwin Bremer Published in: Frontiers in immunology, 2023, ISSN 1664-3224 Publisher: Frontiers Media S.A. DOI: 10.3389/fimmu.2023.1191866 A luminescence-based method to assess antigen presentation and antigen-specific T cell responses for in vitro screening of immunomodulatory checkpoints and therapeutics Author(s): Jimena Álvarez Freile; Yuzhu Qi; Lisa Jacob; Maria Franceskin Lobo; Harm Jan Lourens; Gerwin Huls; Edwin Bremer Published in: Crossref, Issue 2, 2023, ISSN 1664-3224 Publisher: Frontiers Media S.A DOI: 10.3389/fimmu.2023.1233113 Thesis dissertations (1) Advancing Cancer Immunotherapy with Nanomedicine Author(s): Ghizlane Choukrani Published in: 2023 Publisher: University of Groningen DOI: 10.33612/diss.660794643 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
