Glyco-Nanoparticles for Applications in Advance Nanomedicine

Project Information

NanoCarb

Grant agreement ID: 814236

DOI 10.3030/814236

Project closed

EC signature date 20 August 2018

Start date 1 October 2018

End date 31 March 2023

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 4 075 132,26

EU contribution € 4 075 132,26

Coordinated by

ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland

Deliverables

Other (2)

Training weeks

Four training weeks implemented

Supervisory and Scientific Advisory Boards

Set up of the Supervisory board (SB) and the Scientific Advisory Board (SAB).

Websites, patent fillings, videos etc. (3)

Peer reviewed scientific publications

An estimated 30 peer reviewed scientific publications possibly including a special issue in Polymer Chemistry NanoScale ACSNano

Proejct website

NanoCarb website established and online.

Wikipedia page

Creation of a Wikipedia a dedicated page on glyco-nanotechnology following the Wikipedia rules and guidelines. It will give an overview of the aims and objectives of this project and it will be written in a language that will not require a prior learning experience in science.

Publications

Peer reviewed articles (25)

Photo-Induced Microfluidic Production of Ultrasmall Glyco Gold Nanoparticles

Author(s): Patricia Pérez Schmidt, Katiuscia Pagano, Cristina Lenardi, Marta Penconi, Ruth Mateu Ferrando, Claudio Evangelisti, Luigi Lay, Laura Ragona, Marcello Marelli, Laura Polito
Published in:  Angewandte Chemie (International edition), 2022, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202210140

Characterization of Gold Nanorods Conjugated with Synthetic Glycopolymers Using an Analytical Approach Based on spICP-SFMS and EAF4-MALS

Author(s): Milica Velimirovic, Alessia Pancaro, Robert Mildner, Panagiotis G. Georgiou, Kristof Tirez, Inge Nelissen, Christoph Johann, Matthew I. Gibson, and Frank Vanhaecke.
Published in: Nanomaterials, Issue 11(10), 2021, ISSN 1847-9804
Publisher: MDPI
DOI: 10.3390/nano11102720

Synthesis of Poly(2-(methylsulfinyl)ethyl methacrylate) via Oxidation of Poly(2-(methylthio)ethyl methacrylate): Evaluation of the Sulfoxide Side Chain on Cryopreservation

Author(s): Ishibe, Toru; Gonzalez-Martinez, Natalia; Georgiou, Panagiotis G.; Murray, Kathryn A.; Gibson, Matthew I.
Published in: ACS Polymers Au, Issue 2, 6, 2022, Page(s) 449–457, ISSN 2694-2453
Publisher: American Chemical Society
DOI: 10.1021/acspolymersau.2c00028

Glycosylated gold nanoparticles in point of care diagnostics: from aggregation to lateral flow.

Author(s): Alexander N. Baker; George W. Hawker-Bond; Panagiotis G. Georgiou; Simone Dedola; Robert A. Field; Matthew I. Gibson
Published in: Chem Soc Rev, Issue 16, 2022, ISSN 1460-4744
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2cs00267a

Long-term retention of gold nanoparticles in the liver is not affected by their physicochemical characteristics

Author(s): Jennifer Fernandez Alarcon, Mahmoud Soliman, Tanja Ursula Lüdtke, Eva Clemente, Marko Dobricic, Martina B. Violatto, Alessandro Corbelli, Fabio Fiordaliso, Chiara Cordiglieri, Laura Talamini, Giovanni Sitia, Sergio Moya, Paolo Bigini and Marco P. Monopoli
Published in: Nanoscale, 2023, ISSN 2040-3372
Publisher: RSC
DOI: 10.1039/d3nr00685a

The polymeric glyco-linker controls the signal outputs for plasmonic gold nanorod biosensors due to biocorona formation.

Author(s): Alessia Pancaro; Michal Szymonik; Panagiotis G. Georgiou; Alexander N. Baker; Marc Walker; Peter Adriaensens; Jelle Hendrix; Matthew I. Gibson; Inge Nelissen
Published in: Nanoscale, Issue 13, 2021, Page(s) 10837-10848, ISSN 2040-3372
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1nr01548f

Gold nanoparticle-based platforms for vaccine development

Author(s): Ruth Mateu Ferrando; Luigi Lay; Laura Polito
Published in: Drug Discovery Today: Technologies, Issue 1, 2021, Page(s) 57-67, ISSN 1740-6749
Publisher: Elsevier BV
DOI: 10.1016/j.ddtec.2021.02.001

Egg yolk sialylglycopeptide: purification, isolation and characterization of N-glycans from minor glycopeptide species

Author(s): Javier Mauricio Melo Diaz, Alan B. Moran, Simon R. Peel, Jenifer L. Hendel, Daniel I.R. Spencer
Published in: Organic & Biomolecular Chemistry, 2022, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2ob00615d

Ice recrystallisation inhibiting polymer nano-objects via saline-tolerant polymerisation-induced self-assembly

Author(s): Panagiotis G. Georgiou, Ioanna Kontopoulou, Thomas R. Congdon, Matthew I. Gibson
Published in: Materials Horizons, Issue 7/7, 2020, Page(s) 1883-1887, ISSN 2051-6347
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0mh00354a

End-functionalized poly(vinylpyrrolidone) for ligand display in lateral flow device test lines

Author(s): Alexander N. Baker; Thomas R. Congdon; Sarah-Jane Richards; Panagiotis G. Georgiou; Marc Walker; Simone Dedola; Robert A. Field; Robert A. Field; Matthew I. Gibson
Published in: ACS Polym. Au, Issue 30, 2021, Page(s) 69–79, ISSN 2694-2453
Publisher: American Chemical Society
DOI: 10.1021/acspolymersau.1c00032

 Influence of the block copolypeptide surfactant structure on the size of polypeptide nanoparticles obtained by mini emulsion polymerisation

Author(s): Nicola Judge, Dražen Pavlović, Evelin Moldenhauer, Paul Clarke, Ruairi Brannigan, Andreas Heise
Published in: Polymer Chemistry, Issue 13, 2022, ISSN 1759-9962
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2py00331g

Plasmonic Detection of SARS-CoV-2 Spike Protein with Polymer-Stabilized Glycosylated Gold Nanorods

Author(s): Panagiotis G. Georgiou; Collette S. Guy; Muhammad Hasan; Ashfaq Ahmad; Sarah-Jane Richards; Alexander N. Baker; Neer V. Thakkar; Marc Walker; Sarojini Pandey; Neil R. Anderson; Dimitris Grammatopoulos; Matthew I. Gibson
Published in: ACS Macro Lett., Issue 11,3, 2022, Page(s) 317-322, ISSN 2161-1653
Publisher: American Chemical Society
DOI: 10.1021/acsmacrolett.1c00716

Polymer Self-Assembly Induced Enhancement of Ice Recrystallization Inhibition.

Author(s): Panagiotis G. Georgiou; Huba L Marton; Alexander N. Baker; Thomas R. Congdon; Thomas F. Whale; Matthew I. Gibson
Published in: Journal of the American Chemical Society, Issue 31, 2021, Page(s) 7449–7461, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c01963

Lateral Flow Glyco-Assays for the Rapid and Low-Cost Detection of Lectins–Polymeric Linkers and Particle Engineering Are Essential for Selectivity and Performance

Author(s): Alexander N. Baker, Asier R. Muguruza, Sarah-Jane Richards, Panagiotis G. Georgiou, Stephen Goetz, Marc Walker, Simone Dedola, Robert A. Field, and Matthew I. Gibson
Published in: Advanced Healthcare Materials, 2022, ISSN 2192-2659
Publisher: World Scientific
DOI: 10.1002/adhm.202101784

Polymer-tethered glycosylated gold nanoparticles recruit sialylated glycoproteins into their protein corona, leading to off-target lectin binding

Author(s): Ashfaq Ahmad; Panagiotis G. Georgiou; Alessia Pancaro; Muhammad Hasan; Inge Nelissen; Matthew I. Gibson
Published in: Nanoscale, Issue 14, 2022, Page(s) 13261-13273, ISSN 2040-3372
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2nr01818g

Targeting Ultrasmall Gold Nanoparticles with cRGD Peptide Increases the Uptake and Efficacy of Cytotoxic Payload

Author(s): Richard D. Perrins; Lee-Anne McCarthy; Angela Robinson; Kelly L. Spry; Valentin Cognet; Avelino Ferreira; John Porter; Cristina Espinosa Garcίa; Miguel Ángel Rodriguez; Diana Lopez; Ibon Perera; Kelly Conlon; Africa Barrientos; Tom Coulter; Alessandro Pace; Sarah J. M. Hale; Enrico Ferrari; Csanad Z. Bachrati
Published in: Nanomaterials, Issue 12, 2022, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano12224013

Joint Forces of HR-Spicp-MS and EAF4-MALS for Characterization of Gold Nanorods Conjugated with Synthetic Glycopolymers

Author(s): Milica Velimirovic, Alessia Pancaro, Robert Mildner, Panagiotis G. Georgiou, Kristof Tirez, Inge Nelissen, Christoph Johann, Matthew I. Gibson, and Frank Vanhaecke
Published in:  Materials Proceedings, 2021, ISSN 2673-4605
Publisher: MDPI
DOI: 10.3390/iocn2020-07923

“Tuning aggregative versus non-aggregative lectin binding with glycosylated nanoparticles by the nature of the polymer ligand”

Author(s): Panagiotis G. Georgiou, Alexander N. Baker, Sarah-Jane Richards, Antonio Laezza, Marc Walker, Matthew I. Gibson
Published in: Journal of Materials Chemistry B, 2019, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9tb02004g

Probing the glycans accessibility of the nanoparticles biomolecular corona

Author(s): Clemente, Eva
Published in: Journal of Colloid and Interface Science, Issue 613, 2022, Page(s) 563-574, ISSN 0021-9797
Publisher: Academic Press
DOI: 10.5281/zenodo.5020817

Poly(vinyl alcohol) Molecular Bottlebrushes Nucleate Ice

Author(s): Georgiou, Panagiotis G.; Kinney, Nina L. H.; Kontopoulou, Ioanna; Baker, Alexander N.; Hindmarsh, Steven A.; Bissoyi, Akalabya; Congdon, Thomas R.; Whale, Thomas F.; Gibson, Matthew I.
Published in: Biomacromolecules, Issue 23, 2022, Page(s) 5285–5296, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.2c01097

High Molecular Weight Polyproline as a Potential Biosourced Ice Growth Inhibitor: Synthesis, Ice Recrystallization Inhibition, and Specific Ice Face Binding

Author(s): Nicola Judge; Panagiotis G. Georgiou; Akalabya Bissoyi; Ashfaq Ahmad; Andreas Heise; Matthew I. Gibson
Published in:  Biomacromolecules, 2023, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.2c01487

New nanostructures inhibiting human mannose binding lectin identified by a novel surface plasmon resonance assay

Author(s): Gizem Erol; Patricia Perez Schmidt; Alessia Pancaro; Javier M. Melo Diaz; Africa G. Barrientos; John Porter; Laura Polito; Michal Szymonik; Inge Nelissen; Daniel I.R. Spencer; Arianna Piotti; Marten Beeg; Maria-Grazia De Simoni; Stefano Fumagalli; Marco Gobbi
Published in: Sensors and Actuators B: Chemical, Issue 360, 2022, ISSN 0925-4005
Publisher: Elsevier BV
DOI: 10.1016/j.snb.2022.131661

Glycan-Based Flow-Through Device for the Detection of SARS-COV-2

Author(s): Alexander N. Baker, Sarah-Jane Richards, Sarojini Pandey, Collette S. Guy, Ashfaq Ahmad, Muhammad Hasan, Caroline I. Biggs, Panagiotis G. Georgiou, Alexander J. Zwetsloot, Anne Straube, Simone Dedola, Robert A. Field, Neil R. Anderson, Marc Walker, Dimitris Grammatopoulos, and Matthew I. Gibson
Published in: ACS Sensors, 2021, ISSN 2379-3694
Publisher: American Chemical Society
DOI: 10.1021/acssensors.1c01470

Polymer-tethered glyconanoparticle colourimetric biosensors for lectin binding: structural and experimental parameters to ensure a robust output

Author(s): Julian Micallef, Alexander N. Baker, Sarah-Jane Richards, Douglas E. Soutar, Panagiotis G, Georgiou, Marc Walker, Matthew I. Gibson
Published in: Materials Chemistry, 2022, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2ra06265h

Extraction and purification of a High Mannose type oligosaccharide from Phaseolus lunatus beans by oxidative release with sodium hypochlorite

Author(s): Javier Mauricio Melo Diaz; Simon R. Peel; Daniel I.R. Spencer; Jenifer L. Hendel
Published in: Carbohydrate Research, Issue 517, 2022, ISSN 0008-6215
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.carres.2022.108583